Objective To explore the correlation between traditional Chinese medicine (TCM) blood stasis pattern of coronary heart disease (CHD) and coronary angiography result, so as to screen dangerous patterns and provide evidence for the objectification of TCM pattern differentiation.
Methods Literature on correlation between blood stasis pattern and coronary angiography results from January 1992 to May 2012 were searched in the following databases: China Academic Journal Network Publishing Database (CAJD), Chinese Biomedical Literature Database (CBM), China Doctor Dissertation Full-text Database (CDFD), Chinese Selected Master’s Theses Full-Text Databases (CMFD), PubMed and MEDLINE. According to the inclusion and exclusion criteria, literature screening, data extraction and methodological quality assessment of the included studies were conducted. Then meta-analysis was performed using RevMan 5.1 software.
Results A total of 28 studies involving 4 901 patients were included. The results of meta-analysis showed that, there is a significant significance between blood stasis pattern and the following coronary angiography result, namely, number of culprit vessels (OR=1.38, 95%CI 1.08 to 1.77, P lt;0.05), severity of stenosis (OR=1.79, 95%CI 1.04 to 3.08, P lt;0.05), and Gensini score (OR=7.74, 95%CI 3.99 to 11.49, P lt;0.05).
Conclusion Compared with other TCM patterns, CHD with blood stasis pattern easily tends to present multi-vessels lesions, more than 75% stenosis and higher Gensini score, indicating the condition of CHD with blood stasis pattern is more severe than with other patterns. Due to the discrepancy of pattern differentiation and the limited quality of original studies, this conclusion is insufficient to be fully applied into clinical practice, and more large scale and high quality clinical trials are required.
Citation： ZHOU Xiaoqing,LIANG Hao,SUN Xiang,ZHOU Hongtu. Correlation between TCM Blood Stasis Pattern of Coronary Heart Disease and Coronary Angiography Result: A Meta-Analysis. Chinese Journal of Evidence-Based Medicine, 2012, 12(12): 1470-1477. doi: 10.7507/1672-2531.20120227 Copy