Compared with traditional clinical trials, the real-world studies set higher requirements on the authenticity (reality), applicability, and timeliness of the evidence obtained. In this paper, we brought up a hypothesis that creating synergies between observational and experimental studies may meet these requirements. And then it was discussed in three aspects including providing evidence, research design and execution. In addition, data analysis facilitated generating efficient and robust evidence which was in support of decision making. Finally, some enlightenment may be offered for Traditional Chinese Medicine evaluation methods based on the synergies of both study types.
Citation： ZHANG Xiaoyu, CHEN Jing, ZHAO Chen, SHANG Hongcai. Synergy between observational and experimental studies in the real-world research. Chinese Journal of Evidence-Based Medicine, 2018, 18(4): 284-288. doi: 10.7507/1672-2531.201710034 Copy