Master protocol is a great transformation of clinical trials with complete research network, reasonable design and innovative statistical analysis methods. It is a highly efficient new model of clinical trials which could obtain more medical information with less clinical resources. Clinical researches in the field of oncology using master protocol have already made delightful achievements. This paper introduces the design of clinical trials on angina pectoris of coronary heart disease, myocardial infarction and heart failure for instance and discusses the application of master protocol to clinical researches of Traditional Chinese Medicine combined with the differentiation of syndromes and treatments. We expect to provide new ideas and methods for the design of master protocol on diseases with similary syndrome pattern series of Traditional Chinese Medicine.
Citation： HU Jiayuan, ZHANG Xiaoyu, ZHAO Chen, SUN Yang, CHEN Shiqi, LI Chengyu, LIU Shuo, QIU Ruijin, TIAN Guihua, SHANG Hongcai. Master protocol applied to the prevention and treatment of Traditional Chinese Medicine for coronary heart disease: ideas and methods of evidence-based optimization. Chinese Journal of Evidence-Based Medicine, 2019, 19(1): 102-106. doi: 10.7507/1672-2531.201804099 Copy