• 1. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, P.R.China;
  • 2. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P.R.China;
  • 3. Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, P.R.China;
  • 4. Baokang Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R.China;
CHEN Jing, Email: cjshcsyc@126.com; SHANG Hongcai, Email: shanghongcai@foxmail.com
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The characteristics of traditional Chinese medicine (TCM) practice include treatment based on syndrome differentiation and holism, which determines it is difficult to reflect the individualized therapeutic evaluation and overall regulation of TCM through traditional randomized controlled trials, which is based on quantitative evaluation. The implementation of N-of-1 trials will provide opportunities for quantitative evaluation of individualized therapeutic evaluation of TCM. Using mixed methods research, such as exploratory sequence design, interpretive sequence design or convergent design can provide abundant data to individualized therapeutic evaluation of TCM in different aspects, which may reflect holism and humanities characteristics of TCM in individual level.

Citation: QIU Ruijin, ZHAO Chen, ZHONG Changming, HU Jiayuan, LI Min, HUANG Ya, HAN Songjie, HE Tianmai, GUAN Manke, CHEN Jing, SHANG Hongcai. Application of mixed methods research in individualized therapeutic evaluation of clinical trials of traditional Chinese medicine. Chinese Journal of Evidence-Based Medicine, 2020, 20(8): 973-978. doi: 10.7507/1672-2531.201911079 Copy

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