Objective To analyze the global status, hotspots, and trends in atrial fibrillation anticoagulation research.Methods We searched Web of Science Core Collection to collect relevant literature on atrial fibrillation anticoagulation from 2006 to 2020. The visualization software CiteSpace and VOSviewer were used to analyze co-citation, co-occurrence, and emergence analysis on publishing organizations, journals, and keywords and to explore the research hotspots and frontiers.Results A total of 11764 related studies were retrieved. In recent years, research on anticoagulation of atrial fibrillation has become increasingly popular. Most of the published researches were from North America, and the primary institution was the University of Birmingham. Research hotspots mainly focused on warfarin, stroke prevention, new oral anticoagulants, antithrombotic and anticoagulants, and complicating diseases. The research frontiers were the new oral anticoagulants, and the antithrombotic management of atrial fibrillation with coronary heart disease.Conclusions The global hotspot in atrial fibrillation anticoagulant research is warfarin, stroke prevention, new oral anticoagulants, antithrombotic and antiplatelet therapy, and complicated diseases. The research focuses on the study of novel oral anticoagulants and the antithrombotic management of atrial fibrillation complicated with coronary heart disease.
YAO Yi, GUO Ru, WANG Lifei, WU Miaomiao, GUO Zhaoxia, LIU Yi, GOU Zhuang, LIAO Xiaoyang. Global hotspots and trends in atrial fibrillation anticoagulation research. Chinese Journal of Evidence-Based Medicine, 2021, 21(5): 593-600. doi: 10.7507/1672-2531.202011117