• Department of Biliary, Herniary, and Obesity Surgery, Affiliated Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China;
WANG Yong., Email: wangy@sj-hospital.org
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Objectives  To summarize the regulation of glucagon-like peptide-1(GLP-1) level by metabolism of gastrointestinal nutrients.
Methods  Domestic and international publications online involving regulation of GLP-1 level by metabolism of gastrointestinal nutrients in recent years were collected and reviewed.
Results  GLP-1 influenced insulin secretion and sensitivity, and played a leading role in recovery of glucose metabolism. Metabolism of gastrointestinal nutrients regulated GLP-1 level. Studies had shown that GLP-1 was a candidate mediator of the effects of gastric bypass (GBP) for type 2 diabetes mellitus(T2DM).
Conclusions  It plays an important role in anti-T2DM effects of GBP that metabolism of gastrointestinal nutrients regulated GLP-1 level. The corresponding studies can provide a novel clinical field to treat T2DM.

Citation: ENG Xiao,WANG Yong.. Regulation of Glucagon-Like Peptide-1 Level by Metabolism of Gastrointestinal Nutrients. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2012, 19(12): 1286-1290. doi: Copy