• The First Department of General Surgery, No. 3 People’s Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai 201900, China;
JIANG Bojian, Email: jiang_md@hotmail.com
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Objective  To summarize the research progress of gastrointestinal stem cells and its role in gastric neoplasms.
Methods  The literatures related effect of gastrointestinal stem cells niche, gastrointestinal stem cells markers,
and the cancer stem cell theory in the gastric neoplasms were retrieved through PubMed, the research progress of gastrointestinal stem cells and cancer stem cells in the gastric neoplasms was explored.
Results  The cancer stem cell theory arose a decade ago. Gastrointestinal stem cells played a very important role in the gastric neoplasms, which had specific markers and their niches included many kinds of tissue factors. Inflammation could induce gastrointestinal stem cells dysplasia and become cancer stem cells, which promoted the growth, invasion, and metastasis of the gastric neoplasms.
Conclusions  Gastric cancer stem cells could be one of an effective target in treatment for gastric neoplasms, and it may be provide a new breakthrough in treatment for gastric neoplasms.

Citation: WANG Jia,YU Jiwei,JIANG Bojian,.. Gastrointestinal Stem Cells and Research Progress of Its Role in Gastric Neoplasms. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2013, 20(2): 221-226. doi: Copy

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