Comparison of choroid thickness in healthy pregant women and non-pregant women_Chinese Journal of Ocular Fundus Diseases

Authors：

Wu Hanfei ¹ , Ruan Xiaocui ² ,  Zhao Jiawei ¹ , Shen Lijun ³ , Wang Yujie ¹ , Xuan Mengxia ¹ , Fang Huanjie ¹ , Mao Jianbo ³ , Fu Jie ¹

1. Department of Opthalmology, The People’s Hospital of Zhuji, Zhuji 311800, China;
2. Department of Obstetrics, The People’s Hospital of Zhuji, Zhuji 311800, China;
3. Eye Hospital of Wenzhou Medical University, Hangzhou 310020, China;

Corresponding author：

Zhao Jiawei, Email: zjzjw0505@sina.com

Keywords：

Choroid/physiology; Tomography, optical coherence; Pregnant women

DOI：

10.3760/cma.j.cn511434-20190916-00289

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To compare and observe the changes in choroidal thickness between healthy pregnant women and healthy non-pregnant women.Methods A prospective clinical study. From January 2019 to August 2019, healthy pregnant women (pregnant women group) and healthy non-pregnant women age-matched were enrolled during the same period (the normal group) in the obstetrics of Zhuji People's Hospital. All patients were enrolled with their right eyes. Frequency-domain OCT-enhanced depth imaging technology was used to measure the subfoveal macular and 1000 μm above, below, nasal, and temporal choroidal thickness and foveal retinal thickness (CMT). The choroidal thickness and CMT of the pregnant women group and the normal group were compared by t test, and the choroidal thickness and CMT of the normal group and the eyes of different gestational weeks were compared by one-way analysis of variance.Results The pregnant women group and the normal group included 161 patients (161 eyes) and 40 patients (40 eyes). According to the different gestational weeks, the pregnant women were divided into the first trimester group, the second trimester group, and the third trimester group, with 47 patients (47 eyes), 66 patients (66 eyes), and 48 patients (48 eyes) respectively. There was no significant difference in age, axial length, intraocular pressure, and CMT between the different gestational week groups and the normal group (F=1.433, 1.558, 0.416, 2.288; P＞0.05). The subfoveal choroidal thickness (SFCT) of the pregnant women group and normal group were 317.7±73.9 μm and 279.7±44.1 μm, respectively, and the difference was statistically significant (t=3.113, P=0.002). Compared with the normal group, the choroid at the upper, lower, nasal, and temporal sides of the pregnant group 1000 μm from the fovea was thickened. The difference between the upper, nasal and temporal sides was statistically significant (t=2.699, 3.474, 2.595; P＜0.05). The SFCT of the eyes in the first trimester group, the middle group, and the late group were 305.8±72.3, 327.7±69.8, 315.8±80.5 μm, respectively. Compared with the normal group, the difference was statistically significant (F=4.180, P=0.007). Pairwise comparison between the two groups, the second trimester group was significantly different from the normal group (P=0.003). There was no significant difference among the first trimester group、the third trimester group and the other groups (P＞0.05).Conclusion The choroidal thickness of pregnant women is thicker than normal, and the choroidal thickness in the second trimester reaches the maximum value; while the macular CMT during pregnancy has no significant change.

Citation： Wu Hanfei, Ruan Xiaocui, Zhao Jiawei, Shen Lijun, Wang Yujie, Xuan Mengxia, Fang Huanjie, Mao Jianbo, Fu Jie. Comparison of choroid thickness in healthy pregant women and non-pregant women. Chinese Journal of Ocular Fundus Diseases, 2020, 36(8): 620-624. doi: 10.3760/cma.j.cn511434-20190916-00289 Copy

1.	Goktas S, Basaran A, Sakarya Y, et al. Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography[J]. Arq Bras Oftalmol, 2014, 77(3): 148-151. DOI: 10.5935/0004-2749.20140038.
2.	Gaillard R, Bakker R, Willemsen SP, et al. Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders: the Generation R Study[J]. Eur Heart J, 2011, 32(24): 3088-3097. DOI: 10.1093/eurheartj/ehr275.
3.	Sathish S, Arnold JJ. Bilateral choroidal ischaemia and serous retinal detachment in pre-eclampsia[J]. Clin Experiment Ophthalmol, 2000, 28(5): 387-390. DOI: 10.1046/j.1442-9071.2000.00342.x.
4.	Introini U, Casalino G, Cardani A, et al. Intravitreal bevacizumab for a subfoveal myopic choroidal neovascularization in the first trimester of pregnancy[J]. J Ocul Pharmacol Ther, 2012, 28(5): 553-555. DOI: 10.1089/jop.2012.0067.
5.	Jouve L, Akesbi J, Nordmann JP. Safety and efficacy of ranibizumab for pregnant women in idiopathic choroidal neovascularization[J]. Acta Ophthalmol, 2015, 93(7): 97-98. DOI: 10.1111/aos.12611.
6.	洪婷婷, 马子程, 付秀稳, 等. 健康孕妇和子痫前期孕妇黄斑中心凹视网膜厚度和黄斑中心凹下脉络膜厚度对比观察[J]. 中华眼底病杂志, 2017, 33(6): 584-586. DOI: 10.3760/cma.j.issn.1005-1015.2017.06.007.Hong TT, Ma ZC, Fu XW, et al. Comparison of central foveal thickness and subfoveal choroidal thickness in healthy pregnancy and preeclampsia[J]. Chin J Ocul Fundus Dis, 2017, 33(6): 584-586. DOI: 10.3760/cma.j.issn.1005-1015.2017.06.007.
7.	Naderan M, Jahanrad A. Topographic, tomographic and biomechanical corneal changes during pregnancy in patients with keratoconus: a cohort study[J]. Acta Ophthalmol, 2017, 95(4): 291-296. DOI: 10.1111/aos.13296.
8.	Sethi HS, Naik M, Gupta VS. Management of glaucoma in pregnancy: risks or choices, a dilemma?[J]. Int J Ophthalmol, 2016, 9(11): 1684-1690. DOI: 10.18240/ijo.2016.11.24.
9.	李笑天. 妊娠诊断[M]//谢幸, 苟文丽. 妇产科学. 8版. 北京: 人民卫生出版社, 2013: 42-46.Li XT. Diagnosis of pregnancy[M]//Xie X, Gou WL. Obstetrics and Gynaecology. 8th ed. Beijing: People's Medical Publishing House, 2013: 42-46.
10.	Chen HC, Newsom RS, Patel V, et al. Retinal blood flow changes during pregnancy in women with diabetes[J]. Invest Ophthalmol Vis Sci, 1994, 35(8): 3199-3208.
11.	Takahashi J, Kado M, Mizumoto K, et al. Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography[J]. Jpn J Ophthalmol, 2013, 57(5): 435-439. DOI: 10.1007/s10384-013-0265-5.
12.	Benfica CZ, Zanella T, Farias LB, et al. Comparative analysis of choroidal thickness in third trimester pregnant women[J]. Int J Retina Vitreous, 2018, 4: 6. DOI: 10.1186/s40942-018-0108-0.
13.	Sayin N, Kara N, Pirhan D, et al. Subfoveal choroidal thickness in pre-eclampsia: comparison with normal pregnant and nonpregnant women[J]. Semin Ophthalmol, 2014, 29(1): 11-17. DOI: 10.3109/08820538.
14.	Ataş M, Açmaz G, Aksoy H, et al. Evaluation of the macula, retinal nerve fber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography[J]. Hypertens Pregnancy, 2014, 33(3): 299-310. DOI: 10.3109/10641955.
15.	Kara N, Sayin N, Pirhan D, et al. Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography[J]. Curr Eye Res, 2014, 39(6): 642-647. DOI: 10.3109/02713683.
16.	Dadaci Z, Alptekin H, Oncel Acir N, et al. Changes in choroidal thickness during pregnancy detected by enhanced depth imaging optical coherence tomography[J]. Br J Ophthalmol, 2015, 99(9): 1255-1259. DOI: 10.1136/bjophthalmol-2014-306343.
17.	Quillen DA, Gass DM, Brod RD, et al. Central serous chorioretinopathy in women[J]. Ophthalmology, 1996, 103(1): 72-79. DOI: 10.1016/s0161-6420(96)30730-6.
18.	Perkins SL, Kim JE, Pollack JS, et al. Clinical characteristics of central serous chorioretinopathy in women[J]. Ophthalmology, 2002, 109(2): 262-266. DOI: 10.1016/s0161-6420(01)00951-4.
19.	Ulusoy DM, Duru N, Ataş M, et al. Measurement of choroidal thickness and macular thickness during and after pregnancy[J]. Int J Ophthalmol, 2015, 8(2): 321-325. DOI: 10.3980/j.issn.2222-3959.
20.	Demir M, Oba E, Can E, et al. Foveal and parafoveal retinal thickness in healthy pregnant women in their last trimester[J]. Clin Ophthalmol, 2011, 5: 1397-1400. DOI: 10.2147/OPTH.S23944.
21.	Cankaya C, Bozkurt M, Ulutas O. Total macular volume and foveal retinal thickness alterations in healthy pregnant women[J]. Semin Ophthalmol, 2013, 28(2): 103-111. DOI: 10.3109/08820538.

1. Goktas S, Basaran A, Sakarya Y, et al. Measurement of choroid thickness in pregnant women using enhanced depth imaging optical coherence tomography[J]. Arq Bras Oftalmol, 2014, 77(3): 148-151. DOI: 10.5935/0004-2749.20140038.
2. Gaillard R, Bakker R, Willemsen SP, et al. Blood pressure tracking during pregnancy and the risk of gestational hypertensive disorders: the Generation R Study[J]. Eur Heart J, 2011, 32(24): 3088-3097. DOI: 10.1093/eurheartj/ehr275.
3. Sathish S, Arnold JJ. Bilateral choroidal ischaemia and serous retinal detachment in pre-eclampsia[J]. Clin Experiment Ophthalmol, 2000, 28(5): 387-390. DOI: 10.1046/j.1442-9071.2000.00342.x.
4. Introini U, Casalino G, Cardani A, et al. Intravitreal bevacizumab for a subfoveal myopic choroidal neovascularization in the first trimester of pregnancy[J]. J Ocul Pharmacol Ther, 2012, 28(5): 553-555. DOI: 10.1089/jop.2012.0067.
5. Jouve L, Akesbi J, Nordmann JP. Safety and efficacy of ranibizumab for pregnant women in idiopathic choroidal neovascularization[J]. Acta Ophthalmol, 2015, 93(7): 97-98. DOI: 10.1111/aos.12611.
6. 洪婷婷, 马子程, 付秀稳, 等. 健康孕妇和子痫前期孕妇黄斑中心凹视网膜厚度和黄斑中心凹下脉络膜厚度对比观察[J]. 中华眼底病杂志, 2017, 33(6): 584-586. DOI: 10.3760/cma.j.issn.1005-1015.2017.06.007.Hong TT, Ma ZC, Fu XW, et al. Comparison of central foveal thickness and subfoveal choroidal thickness in healthy pregnancy and preeclampsia[J]. Chin J Ocul Fundus Dis, 2017, 33(6): 584-586. DOI: 10.3760/cma.j.issn.1005-1015.2017.06.007.
7. Naderan M, Jahanrad A. Topographic, tomographic and biomechanical corneal changes during pregnancy in patients with keratoconus: a cohort study[J]. Acta Ophthalmol, 2017, 95(4): 291-296. DOI: 10.1111/aos.13296.
8. Sethi HS, Naik M, Gupta VS. Management of glaucoma in pregnancy: risks or choices, a dilemma?[J]. Int J Ophthalmol, 2016, 9(11): 1684-1690. DOI: 10.18240/ijo.2016.11.24.
9. 李笑天. 妊娠诊断[M]//谢幸, 苟文丽. 妇产科学. 8版. 北京: 人民卫生出版社, 2013: 42-46.Li XT. Diagnosis of pregnancy[M]//Xie X, Gou WL. Obstetrics and Gynaecology. 8th ed. Beijing: People's Medical Publishing House, 2013: 42-46.
10. Chen HC, Newsom RS, Patel V, et al. Retinal blood flow changes during pregnancy in women with diabetes[J]. Invest Ophthalmol Vis Sci, 1994, 35(8): 3199-3208.
11. Takahashi J, Kado M, Mizumoto K, et al. Choroidal thickness in pregnant women measured by enhanced depth imaging optical coherence tomography[J]. Jpn J Ophthalmol, 2013, 57(5): 435-439. DOI: 10.1007/s10384-013-0265-5.
12. Benfica CZ, Zanella T, Farias LB, et al. Comparative analysis of choroidal thickness in third trimester pregnant women[J]. Int J Retina Vitreous, 2018, 4: 6. DOI: 10.1186/s40942-018-0108-0.
13. Sayin N, Kara N, Pirhan D, et al. Subfoveal choroidal thickness in pre-eclampsia: comparison with normal pregnant and nonpregnant women[J]. Semin Ophthalmol, 2014, 29(1): 11-17. DOI: 10.3109/08820538.
14. Ataş M, Açmaz G, Aksoy H, et al. Evaluation of the macula, retinal nerve fber layer and choroid in preeclampsia, healthy pregnant and healthy non-pregnant women using spectral-domain optical coherence tomography[J]. Hypertens Pregnancy, 2014, 33(3): 299-310. DOI: 10.3109/10641955.
15. Kara N, Sayin N, Pirhan D, et al. Evaluation of subfoveal choroidal thickness in pregnant women using enhanced depth imaging optical coherence tomography[J]. Curr Eye Res, 2014, 39(6): 642-647. DOI: 10.3109/02713683.
16. Dadaci Z, Alptekin H, Oncel Acir N, et al. Changes in choroidal thickness during pregnancy detected by enhanced depth imaging optical coherence tomography[J]. Br J Ophthalmol, 2015, 99(9): 1255-1259. DOI: 10.1136/bjophthalmol-2014-306343.
17. Quillen DA, Gass DM, Brod RD, et al. Central serous chorioretinopathy in women[J]. Ophthalmology, 1996, 103(1): 72-79. DOI: 10.1016/s0161-6420(96)30730-6.
18. Perkins SL, Kim JE, Pollack JS, et al. Clinical characteristics of central serous chorioretinopathy in women[J]. Ophthalmology, 2002, 109(2): 262-266. DOI: 10.1016/s0161-6420(01)00951-4.
19. Ulusoy DM, Duru N, Ataş M, et al. Measurement of choroidal thickness and macular thickness during and after pregnancy[J]. Int J Ophthalmol, 2015, 8(2): 321-325. DOI: 10.3980/j.issn.2222-3959.
20. Demir M, Oba E, Can E, et al. Foveal and parafoveal retinal thickness in healthy pregnant women in their last trimester[J]. Clin Ophthalmol, 2011, 5: 1397-1400. DOI: 10.2147/OPTH.S23944.
21. Cankaya C, Bozkurt M, Ulutas O. Total macular volume and foveal retinal thickness alterations in healthy pregnant women[J]. Semin Ophthalmol, 2013, 28(2): 103-111. DOI: 10.3109/08820538.

Chinese Journal of Ocular Fundus Diseases

Comparison of choroid thickness in healthy pregant women and non-pregant women

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content