Correlation of inner-retinal irregularity index with visual function before and after surgery in idiopathic macular epiretinal membrane_Chinese Journal of Ocular Fundus Diseases

Authors：

Zeng Miao ,  Chen Xiao , Hong Ling , Cai Chunyan , Ding Qin

Department of Ophthalmology, Central Theater Command General Hospital, Wuhan 430070, China;

Corresponding author：

Chen Xiao, Email: cxfn817@163.com

Keywords：

Epiretinal membrane; Macula lutea; Vitrectomy; Tomography, optical coherence; Inner-retinal irregularity index; Visual function

DOI：

10.3760/cma.j.cn511434-20200117-00028

Video：

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Objective To observe the changes of the inner-retinal irregularity index (IRII) of eyes with idiopathic macular epiretinal membrane (IMEM) before and after surgery and its correlation with visual function.Methods retrospective series of studies. From March 2017 to May 2018, 46 IMEM patients (46 eyes) diagnosed in the Department of Ophthalmology of Central Theater Command General Hospital were included in the study. BCVA, visual deformation degree (M), OCT inspection with swept source were all performed. The BCVA examination was carried out using the international standard visual acuity chart, which was converted into logMAR visual acuity for record. The average IRII was 1.255±0.048, the average logMAR BCVA was 0.63±0.21, the average M value was 0.68±0.38, the average of central macular thickness (CMT) was 353.57±73.92 μm, the average inner retinal layer thickness (IRT) was 181.50±40.91 μm. The complete and incomplete ellipsoid zone (EZ) were 17 and 29 eyes, respectively. All eyes underwent a 25G three-incision closed vitrectomy through the flat part of the ciliary body, and the epiretinal membrane and inner limiting membrane were removed at the same time. The changes of IRII, M value, BCVA, CMT, IRT and EZ were observed at 1, 3, 6, and 12 months after surgery, and the correlation were analyzed between IRII and M value and BCVA before and after surgery. Single-factor repeated measurement data analysis of variance was used for the comparison of BCVA, M value, CMT, and IRT before and after surgery. Spearman rank correlation analysis were adopted for the correlation analysis between IRII and BCVA, M value, CMT, IRT and EZ integrity before and after surgery.Results Twelve months after surgery, the average IRII and logMAR BCVA were 1.175±0.032 and 0.47±0.16, respectively. Compared with those before surgery, they were significantly improved, and the difference was statistically significant (F=22.273, 5.453; P＜0.001, ＜0.001). The average M value (F=20.109), CMT (F=14.273), IRN (F=13.665) were significantly lower than those before the operation, and the difference was statistically significant (P＜0.001, 0.001, ＜0.001). The integrity of EZ was significantly improved compared with that before surgery, and the difference was statistically significant (χ²=12.715, P＜0.001). The results of correlation analysis showed that preoperative IRII was positively correlated with preoperative M value and CMT (r=0.951, 0.701; P＜0.001, ＜0.001). It was positively correlated with postoperative M value, logMAR BCVA, CMT and EZ integrity (r=0.650, 0.369, 0.720, 0.293; P＜0.001, ＜0.001, P=0.048). It was not correlated with preoperative logMAR BCVA and EZ integrity (r=0.283, 0.001; P=0.056, 0.996).Conclusion The IRII of IMEM eyes before surgery is significantly correlated with the BCVA and M values after surgery.

Citation： Zeng Miao, Chen Xiao, Hong Ling, Cai Chunyan, Ding Qin. Correlation of inner-retinal irregularity index with visual function before and after surgery in idiopathic macular epiretinal membrane. Chinese Journal of Ocular Fundus Diseases, 2020, 36(11): 874-879. doi: 10.3760/cma.j.cn511434-20200117-00028 Copy

1.	Bu SC, Kuijer R, Li XR, et al. Idiopathic epiretinal membrane[J]. Retina, 2014, 34(12): 2317-2335. DOI: 10.1097/iae.0000000000000349.
2.	Bringmann A, Wiedemann P. Involvement of Müller glial cells in epiretinal membrane formation[J]. Graefe's Arch Clin Exp Ophthalmol, 2009, 247(7): 865-883. DOI: 10.1007/s00417-009-1082-x.
3.	Kim JH, Kang SW, Kong MG, et al. Assessment of retinal layers and visual rehabilitation after epiretinal membrane removal[J]. Graefe's Arch Clin Exp Ophthalmol, 2013, 251(4): 1055-1064. DOI: 10.1007/s00417-012-2120-7.
4.	Asaria R, Garnham L, Gregor ZJ, et al. A prospective study of binocular visual function before and after successful surgery to remove a unilateral epiretinal membrane[J]. Ophthalmology, 2008, 115(11): 1930-1937. DOI: 10.1016/j.ophtha.2008.05.020.
5.	Inoue M, Morita S, Watanabe Y, et al. Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane[J]. Am J Ophthalmol, 2010, 150(6): 834-839. DOI: 10.1016/j.ajo.2010.06.006.
6.	Shimozono M, Oishi A, Hata M, et al. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery[J]. Am J Ophthalmol, 2012, 153(4): 698-704. DOI: 10.1016/j.ajo.2011.09.011.
7.	Joe SG, Lee KS, Lee JY, et al. Inner retinal layer thickness is the major determinant of visual acuity in patients with idiopathic epiretinal membrane[J/OL]. Acta Ophthalmol, 2013, 91(3): 242-243[2012-12-31]. https://pubmed.ncbi.nlm.nih.gov/23280145/. DOI: 10.1111/aos.12017.
8.	Cho KH, Park SJ, Cho JH, et al. Inner-retinal irregularity index predicts postoperative visual prognosis in idiopathic epiretinal membrane[J]. Am J Ophthalmol, 2016, 168(8): 139-149. DOI: 10.1016/j.ajo.2016.05.011.
9.	Pournaras CJ, Donati G, Brazilikos PD, et al. Macular epiretinal membranes[J]. Semin Ophthalmol, 2000, 15(2): 100-107. DOI: 10.3109/08820530009040000.
10.	曾苗, 陈晓, 洪玲, 等. 特发性黄斑前膜患眼玻璃体切割联合内界膜剥除手术前后视力视物变形与黄斑形态的相关性[J]. 中华眼底病杂志, 2017, 33(4): 378-382. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.012.Zeng M, Chen X, Hong L, et a1. Correlation of visual acuity and metamorphopsia with foveaI morphology before and after vitrectomy with internal limiting membrane peeling in idiopathic macular epiretinaI membrane eyes[J]. Chin J Ocul Fundus Dis, 2017, 33(4): 378-382. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.012.
11.	Bae SH, Kim D, Park TK, et al. Preferential hyperacuity perimeter and prognostic factors for metamorphopsia after idiopathic epiretinal membrane surgery[J]. Am J Ophthalmol, 2013, 155(1): 109-117. DOI: 10.1016/j.ajo.2012.07.007.
12.	Clark A, Balducci N, Pichi F, et al. Swelling of the arcuate nerve fiber layer after internal limiting membrane peeling[J]. Retina, 2012, 32(8): 1608-1613. DOI: 10.1097/IAE.0b013e3182437e86.
13.	Tadayoni R, Paques M, Massin P, et al. Dissociated optic nerve fiber layer appearance of the fundus after idiopathic epiretinal membrane removal[J]. Ophthalmology, 2001, 108(12): 2279-2283. DOI: 10.1016/S0161-6420(01)00856-9.
14.	Bouwens MD, De Jong F, Mulder P, et al. Results of macular pucker surgery: 1-and 5-year follow-up[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(12): 1693-1697. DOI: 10.1007/s00417-008-0909-1.
15.	García-Fernández M, Castro Navarro J, González Castaño C, et al. Epiretinal membrane surgery: anatomic and functional outcomes[J]. Arch Soc Esp Oftalmol, 2013, 88(4): 139-144. DOI: 10.1016/j.oftale.2012.07.002.

1. Bu SC, Kuijer R, Li XR, et al. Idiopathic epiretinal membrane[J]. Retina, 2014, 34(12): 2317-2335. DOI: 10.1097/iae.0000000000000349.
2. Bringmann A, Wiedemann P. Involvement of Müller glial cells in epiretinal membrane formation[J]. Graefe's Arch Clin Exp Ophthalmol, 2009, 247(7): 865-883. DOI: 10.1007/s00417-009-1082-x.
3. Kim JH, Kang SW, Kong MG, et al. Assessment of retinal layers and visual rehabilitation after epiretinal membrane removal[J]. Graefe's Arch Clin Exp Ophthalmol, 2013, 251(4): 1055-1064. DOI: 10.1007/s00417-012-2120-7.
4. Asaria R, Garnham L, Gregor ZJ, et al. A prospective study of binocular visual function before and after successful surgery to remove a unilateral epiretinal membrane[J]. Ophthalmology, 2008, 115(11): 1930-1937. DOI: 10.1016/j.ophtha.2008.05.020.
5. Inoue M, Morita S, Watanabe Y, et al. Inner segment/outer segment junction assessed by spectral-domain optical coherence tomography in patients with idiopathic epiretinal membrane[J]. Am J Ophthalmol, 2010, 150(6): 834-839. DOI: 10.1016/j.ajo.2010.06.006.
6. Shimozono M, Oishi A, Hata M, et al. The significance of cone outer segment tips as a prognostic factor in epiretinal membrane surgery[J]. Am J Ophthalmol, 2012, 153(4): 698-704. DOI: 10.1016/j.ajo.2011.09.011.
7. Joe SG, Lee KS, Lee JY, et al. Inner retinal layer thickness is the major determinant of visual acuity in patients with idiopathic epiretinal membrane[J/OL]. Acta Ophthalmol, 2013, 91(3): 242-243[2012-12-31]. https://pubmed.ncbi.nlm.nih.gov/23280145/. DOI: 10.1111/aos.12017.
8. Cho KH, Park SJ, Cho JH, et al. Inner-retinal irregularity index predicts postoperative visual prognosis in idiopathic epiretinal membrane[J]. Am J Ophthalmol, 2016, 168(8): 139-149. DOI: 10.1016/j.ajo.2016.05.011.
9. Pournaras CJ, Donati G, Brazilikos PD, et al. Macular epiretinal membranes[J]. Semin Ophthalmol, 2000, 15(2): 100-107. DOI: 10.3109/08820530009040000.
10. 曾苗, 陈晓, 洪玲, 等. 特发性黄斑前膜患眼玻璃体切割联合内界膜剥除手术前后视力视物变形与黄斑形态的相关性[J]. 中华眼底病杂志, 2017, 33(4): 378-382. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.012.Zeng M, Chen X, Hong L, et a1. Correlation of visual acuity and metamorphopsia with foveaI morphology before and after vitrectomy with internal limiting membrane peeling in idiopathic macular epiretinaI membrane eyes[J]. Chin J Ocul Fundus Dis, 2017, 33(4): 378-382. DOI: 10.3760/cma.j.issn.1005-1015.2017.04.012.
11. Bae SH, Kim D, Park TK, et al. Preferential hyperacuity perimeter and prognostic factors for metamorphopsia after idiopathic epiretinal membrane surgery[J]. Am J Ophthalmol, 2013, 155(1): 109-117. DOI: 10.1016/j.ajo.2012.07.007.
12. Clark A, Balducci N, Pichi F, et al. Swelling of the arcuate nerve fiber layer after internal limiting membrane peeling[J]. Retina, 2012, 32(8): 1608-1613. DOI: 10.1097/IAE.0b013e3182437e86.
13. Tadayoni R, Paques M, Massin P, et al. Dissociated optic nerve fiber layer appearance of the fundus after idiopathic epiretinal membrane removal[J]. Ophthalmology, 2001, 108(12): 2279-2283. DOI: 10.1016/S0161-6420(01)00856-9.
14. Bouwens MD, De Jong F, Mulder P, et al. Results of macular pucker surgery: 1-and 5-year follow-up[J]. Graefe's Arch Clin Exp Ophthalmol, 2008, 246(12): 1693-1697. DOI: 10.1007/s00417-008-0909-1.
15. García-Fernández M, Castro Navarro J, González Castaño C, et al. Epiretinal membrane surgery: anatomic and functional outcomes[J]. Arch Soc Esp Oftalmol, 2013, 88(4): 139-144. DOI: 10.1016/j.oftale.2012.07.002.

Chinese Journal of Ocular Fundus Diseases

Correlation of inner-retinal irregularity index with visual function before and after surgery in idiopathic macular epiretinal membrane

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