Frequency domain optical coherence tomography of human Henle fiber layer_Chinese Journal of Ocular Fundus Diseases

Authors：

WengMing ,  ChenChangzhen , FanWen , 易佐慧子 , 郑红梅

People's Hospital Eye Center, Wuhan University, Wuhan 430060, China;

Corresponding author：

ChenChangzhen, Email: whuchenchzh@163.com

Keywords：

Photoreceptor cells; Tomography, optical coherence

DOI：

10.3760/cma.j.issn.1005-1015.2014.06.003

Video：

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Objective To observe the frequency domain optical coherence tomography (SD-OCT) features of Henle fiber layer (HFL) of health adults in china by changing the angle of the measurement beam. Methods Twenty-four subjects (28 eyes) who showed no abnormalities on routine eye examination were included in the study, including 15 males (16 eyes) and 9 females (12 eyes) with an average age of (35.51±3.54) years old, and mean refraction power of (-0.89±1.15) D. All subjects underwent corrected visual acuity, intraocular pressure, slit lamp microscope, direct ophthalmoscope, visual field and SD-OCT examination. The macular area was scanned by Zeiss Cirrus SD-OCT (5 HD line) single line scan mode. Based on the entry position of the SD-OCT beam through the pupil, the subjects were divided into 3 groups, including group A (center of the pupil), group B (near the temporal edge of the pupil) and group C (near the nasal edge of the pupil). The thickness of outer plexiform layer (OPL), HFL, and outer nuclear layer (ONL) were measured at 0.75 mm, 1.50 mm from the fovea. Results When entry position of the SD-OCT beam was near the temporal edge of the pupil (group B); there were two layer structures with different signal intensities in the weak reflectivity zones in front of the external limiting membrane (ELM). The signal of the inner layer was slightly higher than the outer layer. The OPL thickness at the decreased side (nasal) increased significantly compared with the other side, but the ONL thickness was significantly thinner than other side. When entry position of the SD-OCT beam was near the nasal edge of the pupil (group C), there were also two layer structures with different signal intensities in the weak reflectivity zones in front of the ELM. The signal of the outer layer was slightly higher than the inner layer. The OPL thickness at the decreased side (temporal) increased significantly compared with the other side, but the ONL thickness was significantly thinner than other side. The OPL thickness at the decreased side was significantly different between these 3 groups (P < 0.01). Conclusions SD-OCT provided the possibility of distinguishing HFL from the actual ONL by changing the angle of the measurement beam. This finding has great clinical significance for related diseases affecting HFL or ONL.

Citation： WengMing, ChenChangzhen, FanWen. Frequency domain optical coherence tomography of human Henle fiber layer. Chinese Journal of Ocular Fundus Diseases, 2014, 30(6): 545-548. doi: 10.3760/cma.j.issn.1005-1015.2014.06.003 Copy

1.	李西玲, 谢成.黄斑水肿的光相干断层扫描分析[J].中华眼底病杂志, 2004, 20:152-155.
2.	Matsumoto H, Sato T, Kishi IS. Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy[J]. Am J Ophthalmol, 2009, 48:105-110.
3.	黎晓新, 赵明威.我国近五年眼底病诊疗技术进展[J].中华眼科杂志, 2010, 46:900-904.
4.	Lujan BJ, Roorda A, Knighton RW, et al. Revealing Henle's fiber layer using spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52:1486-1492.
5.	Otani T, Yamaguchi Y, Kishi S. Improved visualization of Henle fiber layer by changing the measurment beam angle on optical coherence tomagraphy[J].Retina, 2011, 31:497-501.
6.	黎晓新, 陈玮志.光学相干断层扫描检查图像及解读分析[J].中华眼底病杂志, 2012, 28:84-88.
7.	孙心铨, 刘晓玲.解读视网膜外层及色素上皮层的3D-OCT图像和临床意义[J].中华眼视光学与视觉科学杂志, 2010, 12:324-327.
8.	李瑞峰.正确理解眼底组织光学特点, 合理解析光相干断层扫描图像[J].中华眼底病杂志, 2009, 25:210-212.
9.	Zhou Q. Retinal scanning laser polarimetry and methods to compensate for corneal birefringence[J]. Bull Soc Belge Ophtalmol, 2006, 302:89-106.
10.	孙思勤.相干光断层扫描在眼前节的应用[J].国际眼科纵览, 2006, 30:289-291.
11.	Arevalo JF, Krivoy D, Fernandez CF.How does optical coherence tomography work basic principles?[M]//Arevalo JF.Retinal angiography and optical coherence tomography. New York:Spring, 2009:217-222.
12.	Soliman W, Sander B, Jorgensen TM. Enhanced optical coherence patterns of diabetic macular oedema and their correlation with the pathophysiology[J]. Acta Ophthalmol Scand, 2008, 85:613-617.
13.	Drasdo N, Millican CL, Katholi CR, et al. The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field[J].Vision Res, 2007, 47:2901-2911.
14.	Ahlers C, Geitzenauer W, Stock G, et al. Alterations of intraretinal layers in acute central serous chorioretinopathy[J]. Acta Ophthalmol, 2009, 87:511-516.
15.	Kishi S, Kamei Y, Shimizu K, et al. Tractional elevation of Henle's fiber layer in idiopathic macular holes[J]. Am J Ophthalmol, 1995, 120:486-496.
16.	Elsner AE, Weber A, Cheney MC, et al. Spatial distribution of macular birefringence associated with the henle fiber[J]. Vision Res, 2008, 48:2578-2585.
17.	Mones J, Biarnes M, Trindade F, et al. Optical coherence tomoography assessment of apparent foveal swelling in patients with foveal sparing secondary to geographic atrophy[J].Ophthalmology, 2013, 120:829-836.
18.	牟晓月, 孙祖华, 贾晓林, 等.中心性浆液性脉络膜视网膜病变光感受器层频域光学相干断层扫描的观察[J].中华眼视光学与视觉科学杂志, 2011, 13:169-172.

1. 李西玲, 谢成.黄斑水肿的光相干断层扫描分析[J].中华眼底病杂志, 2004, 20:152-155.
2. Matsumoto H, Sato T, Kishi IS. Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy[J]. Am J Ophthalmol, 2009, 48:105-110.
3. 黎晓新, 赵明威.我国近五年眼底病诊疗技术进展[J].中华眼科杂志, 2010, 46:900-904.
4. Lujan BJ, Roorda A, Knighton RW, et al. Revealing Henle's fiber layer using spectral domain optical coherence tomography[J]. Invest Ophthalmol Vis Sci, 2011, 52:1486-1492.
5. Otani T, Yamaguchi Y, Kishi S. Improved visualization of Henle fiber layer by changing the measurment beam angle on optical coherence tomagraphy[J].Retina, 2011, 31:497-501.
6. 黎晓新, 陈玮志.光学相干断层扫描检查图像及解读分析[J].中华眼底病杂志, 2012, 28:84-88.
7. 孙心铨, 刘晓玲.解读视网膜外层及色素上皮层的3D-OCT图像和临床意义[J].中华眼视光学与视觉科学杂志, 2010, 12:324-327.
8. 李瑞峰.正确理解眼底组织光学特点, 合理解析光相干断层扫描图像[J].中华眼底病杂志, 2009, 25:210-212.
9. Zhou Q. Retinal scanning laser polarimetry and methods to compensate for corneal birefringence[J]. Bull Soc Belge Ophtalmol, 2006, 302:89-106.
10. 孙思勤.相干光断层扫描在眼前节的应用[J].国际眼科纵览, 2006, 30:289-291.
11. Arevalo JF, Krivoy D, Fernandez CF.How does optical coherence tomography work basic principles?[M]//Arevalo JF.Retinal angiography and optical coherence tomography. New York:Spring, 2009:217-222.
12. Soliman W, Sander B, Jorgensen TM. Enhanced optical coherence patterns of diabetic macular oedema and their correlation with the pathophysiology[J]. Acta Ophthalmol Scand, 2008, 85:613-617.
13. Drasdo N, Millican CL, Katholi CR, et al. The length of Henle fibers in the human retina and a model of ganglion receptive field density in the visual field[J].Vision Res, 2007, 47:2901-2911.
14. Ahlers C, Geitzenauer W, Stock G, et al. Alterations of intraretinal layers in acute central serous chorioretinopathy[J]. Acta Ophthalmol, 2009, 87:511-516.
15. Kishi S, Kamei Y, Shimizu K, et al. Tractional elevation of Henle's fiber layer in idiopathic macular holes[J]. Am J Ophthalmol, 1995, 120:486-496.
16. Elsner AE, Weber A, Cheney MC, et al. Spatial distribution of macular birefringence associated with the henle fiber[J]. Vision Res, 2008, 48:2578-2585.
17. Mones J, Biarnes M, Trindade F, et al. Optical coherence tomoography assessment of apparent foveal swelling in patients with foveal sparing secondary to geographic atrophy[J].Ophthalmology, 2013, 120:829-836.
18. 牟晓月, 孙祖华, 贾晓林, 等.中心性浆液性脉络膜视网膜病变光感受器层频域光学相干断层扫描的观察[J].中华眼视光学与视觉科学杂志, 2011, 13:169-172.

Chinese Journal of Ocular Fundus Diseases

Frequency domain optical coherence tomography of human Henle fiber layer

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