The correlational study between serum Apelin and blood lipid level in diabetic retinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

 ChengJintao , QiJinze , LiangJiamei , 张庆芬

Department of Ophthalmology of Yishui Central Hospital, Linyi 276400, China;

Corresponding author：

ChengJintao, Email: cjtao799@sohu.com

Keywords：

Diabetic retinopathy/etiology; Dyslipidemias/metabolism; Adipokines

DOI：

10.3760/cma.j.issn.1005-1015.2015.02.007

Video：

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Objective To investigate the role of apelin, glycosylated hemoglobin (HbA1c), cholesterol (TC), triglyceride (TG), High density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDLC) in the development and progress of diabetic retinopathy (DR). Methods The serum concentration of apelin, HbA1c, TC, TG, HDLC and LDLC were measured in 30 normal control subjects and 90 patients with type 2 diabetic mellitus, including 30 cases without DR (NDR), 30 with non-proliferative DR (NPDR), 30 with proliferative DR (PDR). These data were analyzed by SPSS for windows 13.0. Results The serum concentration of apelin, HbA1c, TC, HDLC, LDLC were significantly higher in NDR, NPDR, PDR group than those in control group (F=403.06, 5.45, 4.27, 201.56, 4.90;P < 0.05). The serum concentration of TG has no significantly difference (F=2.19, P > 0.05). The serum concentration of apelin, HbA1c, TC, LDLC were significantly higher in NDR, NPDR, PDR group than those in control group (t=0.30, 0.58, 0.79;P < 0.05), the serum concentration of HDLC were significantly lower than those in control group(t=0.79, P < 0.01). There were significantly positive correlation between the progression of DR and the serum concentration of apelin, HbA1c, TC, LDLC(r=0.962, 0.562, 0.935;P < 0.05). There were significantly negative correlation between the progression of DR and the serum concentration of HDLC(r=-0.753, P < 0.01). There were correlation between apelin and HbA1c, LDLC and HDLC(r=0.956, 0.741, -0.691;P < 0.01). Conclusion Our data demonstrated that serum apelin levels increased significantly in patients with diabetic retinopathy, and are closely related to blood sugar, blood lipid metabolic abnormalities.

Citation： ChengJintao, QiJinze, LiangJiamei. The correlational study between serum Apelin and blood lipid level in diabetic retinopathy. Chinese Journal of Ocular Fundus Diseases, 2015, 31(2): 139-142. doi: 10.3760/cma.j.issn.1005-1015.2015.02.007 Copy

1.	Liebl A. Challenges in optimal metabolic control of diabetes[J]. Diabetes Metab Res Rev, 2002, 18 Suppl 3:S36-41.
2.	Chang YC, Wu WC. Dyslipidemia and diabetic retinopathy[J]. Rev Diabet Stud, 2013, 10(2-3):121-132.
3.	Kalin RE, Kretz MP, Meyer AM, et al. Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis[J]. Dev Biol, 2007, 305(2):599-614.
4.	De Falco M, Fedele V, Russo T, et al. Distribution of apelin, the endogenous ligand of the APJ receptor, in the lizard Podarcis sicula[J]. J Mol Histol, 2004, 35(5):521-527.
5.	Castan-Laurell I, Boucher J, Dray C, et al.Apelin, a novel adipokine over-produced in obesity:friend or foe?[J]. Mol Cell Endocrinol, 2005, 245(1-2):7-9.
6.	Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J]. Biochem Biophys Res Commun, 1998, 251(2):471-476.
7.	Jun-Hui Du, Xia Li, Rong Li, et al. Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients[J]. Int J Ophthalmol, 2014, 7(6):968-973.
8.	Tao Y, Lu Q, Jiang YR, et al. Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2010, 51(8):4237-4242.
9.	Kasai A, Shintani N, Oda M. Apelin is a novel angiogenic factor in retinal endothelial cells[J]. Biochem Biophys Res Commun, 2004, 325(2):395-400.
10.	Yu S, Zhang Y, Li MZ, et al. Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients[J]. Chin Med J (Engl), 2012, 125(19):3440-3444.
11.	Garcia-Diaz D, Campion J, Milagro FI, et al. Adiposity dependent apelin gene expression:relationships with oxidative and inflammation markers[J]. Mol Cell Biochem, 2007, 305(1-2):87-94.
12.	Daviaud D, Boucher J, Gesta S. TNFalpha up-regulates apelin expression in human and mouse adipose tissue[J]. FASEB J, 2006, 20(9):1528-1530.
13.	Tiani C, Garcia-Pras E, Mejias M. Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension[J]. J Hepatol, 2009, 50(2):296-305.
14.	Garberg G, Lövestam-Adrian M, Nasic S, et al.The prognosis of diabetic retinopathy in patients with type 2 diabetes since 1996-1998:the Skaraborg Diabetes Register.Int Ophthalmol, 2014, 8:E1. http://link.springer.com/article/10.1007%2Fs10792-014-9976-y..
15.	Turk Z, Mesić R, Benko B.Comparison of advanced glycation endproducts on haemoglobin (Hb-AGE) and haemoglobin A1c for the assessment of diabetic control[J]. Clin Chim Acta, 1998, 277(2):159-170.
16.	Agroiya P, Philip R, Saran S, et al. Association of serum lipids with diabetic retinopathy in type 2 diabetes[J]. Indian J Endocrinol Metab, 2013, 17(Suppl 1):S335-337.
17.	Cetin EN, Bulgu Y, Ozdemir S, et al. Association of serum lipid levels with diabetic retinopathy[J]. Int J Ophthalmol, 2013, 6(3):346-349.

1. Liebl A. Challenges in optimal metabolic control of diabetes[J]. Diabetes Metab Res Rev, 2002, 18 Suppl 3:S36-41.
2. Chang YC, Wu WC. Dyslipidemia and diabetic retinopathy[J]. Rev Diabet Stud, 2013, 10(2-3):121-132.
3. Kalin RE, Kretz MP, Meyer AM, et al. Paracrine and autocrine mechanisms of apelin signaling govern embryonic and tumor angiogenesis[J]. Dev Biol, 2007, 305(2):599-614.
4. De Falco M, Fedele V, Russo T, et al. Distribution of apelin, the endogenous ligand of the APJ receptor, in the lizard Podarcis sicula[J]. J Mol Histol, 2004, 35(5):521-527.
5. Castan-Laurell I, Boucher J, Dray C, et al.Apelin, a novel adipokine over-produced in obesity:friend or foe?[J]. Mol Cell Endocrinol, 2005, 245(1-2):7-9.
6. Tatemoto K, Hosoya M, Habata Y, et al. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor[J]. Biochem Biophys Res Commun, 1998, 251(2):471-476.
7. Jun-Hui Du, Xia Li, Rong Li, et al. Elevation of serum apelin-13 associated with proliferative diabetic retinopathy in type 2 diabetic patients[J]. Int J Ophthalmol, 2014, 7(6):968-973.
8. Tao Y, Lu Q, Jiang YR, et al. Apelin in plasma and vitreous and in fibrovascular retinal membranes of patients with proliferative diabetic retinopathy[J]. Invest Ophthalmol Vis Sci, 2010, 51(8):4237-4242.
9. Kasai A, Shintani N, Oda M. Apelin is a novel angiogenic factor in retinal endothelial cells[J]. Biochem Biophys Res Commun, 2004, 325(2):395-400.
10. Yu S, Zhang Y, Li MZ, et al. Chemerin and apelin are positively correlated with inflammation in obese type 2 diabetic patients[J]. Chin Med J (Engl), 2012, 125(19):3440-3444.
11. Garcia-Diaz D, Campion J, Milagro FI, et al. Adiposity dependent apelin gene expression:relationships with oxidative and inflammation markers[J]. Mol Cell Biochem, 2007, 305(1-2):87-94.
12. Daviaud D, Boucher J, Gesta S. TNFalpha up-regulates apelin expression in human and mouse adipose tissue[J]. FASEB J, 2006, 20(9):1528-1530.
13. Tiani C, Garcia-Pras E, Mejias M. Apelin signaling modulates splanchnic angiogenesis and portosystemic collateral vessel formation in rats with portal hypertension[J]. J Hepatol, 2009, 50(2):296-305.
14. Garberg G, Lövestam-Adrian M, Nasic S, et al.The prognosis of diabetic retinopathy in patients with type 2 diabetes since 1996-1998:the Skaraborg Diabetes Register.Int Ophthalmol, 2014, 8:E1. http://link.springer.com/article/10.1007%2Fs10792-014-9976-y..
15. Turk Z, Mesić R, Benko B.Comparison of advanced glycation endproducts on haemoglobin (Hb-AGE) and haemoglobin A1c for the assessment of diabetic control[J]. Clin Chim Acta, 1998, 277(2):159-170.
16. Agroiya P, Philip R, Saran S, et al. Association of serum lipids with diabetic retinopathy in type 2 diabetes[J]. Indian J Endocrinol Metab, 2013, 17(Suppl 1):S335-337.
17. Cetin EN, Bulgu Y, Ozdemir S, et al. Association of serum lipid levels with diabetic retinopathy[J]. Int J Ophthalmol, 2013, 6(3):346-349.

Chinese Journal of Ocular Fundus Diseases

The correlational study between serum Apelin and blood lipid level in diabetic retinopathy

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