Observation on imaging features of two types of fundus autofluorescence and spectral-domain optical coherence tomography in acute central serous chorioretinopathy_Chinese Journal of Ocular Fundus Diseases

Authors：

ZhangPeng , WangHaiyan , ZhangZifeng , 苏晓娜 , 孙董洁 , 朱锦亭 , 李娟 ,  王雨生

Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Eye Institute of Chinese PLA, Xi'an 710032, China;

Corresponding author：

王雨生, Email: wangys003@126.com

Keywords：

Central serous chorioretinopathy; Tomography, optical coherence; Fluorescein angiography; Diagnostic imaging

DOI：

10.3760/cma.j.issn.1005-1015.2015.03.007

Video：

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Objective To observe the imaging features of short-wave length fundus autofluorescence (SW-AF), near-infrared fundus autofluorescence (NIR-AF)and spectral-domain optical coherence tomograph (SD-OCT) in acute central serous chorioretinopathy (CSC). Methods This is a retrospective observational consecutive case series study. Eighty-two eyes with acute CSC from 76 patients were enrolled in this study.There were 50 males (56 eyes) and 26 females (26 eyes), average age was (41.32±7.37) years old, average course of the disease was (0.47±1.73) months. The routine clinical examinations included best corrected visual acuity, slit lamp microscope, indirect ophthalmoscope, fundus fluorescein angiography (FFA), SW-AF, NIR-AF and SD-OCT. The imaging features of NIR-AF, SW-AF, SD-OCT and FFA in same eye with acute CSC were analyzed comparatively. Results SD-OCT showed retinal pigment epithelium (RPE) detachment corresponding to RPE leakage point on FFA images in all CSC eyes. RPE leakage points in all eyes corresponding to local hypo-NIR-AF, whereas corresponding to normal SW-AF. NIR-AF demonstrated the area of decreased AF corresponding to serous retinal detachment in all eyes, of which, the area of hypo-SW-AF was consistent with that of sensory retinal detachment in 75 eyes. Except for RPE leaking fluorescein in 82 eyes, FFA showed window defects corresponding to clusters of hypo-NIR-AF in 45 eyes, of which, 27 eyes showed hypo-SW-AF appearing concurrently with the locations of window defects of FFA. In 18 eyes, the extent and amount of hypo-SW-AF were less than that of hypo-NIR-AF. Conclusions There was local RPE detachment in all eyes with acute CSC. The locations of sensory retinal detachment, local RPE detachment and RPE depigmentation showed hypo-NIR-AF. The locations of sensory retinal detachment and RPE depigmentation showed hypo-SW-AF in most of acute CSC eyes.

Citation： ZhangPeng, WangHaiyan, ZhangZifeng. Observation on imaging features of two types of fundus autofluorescence and spectral-domain optical coherence tomography in acute central serous chorioretinopathy. Chinese Journal of Ocular Fundus Diseases, 2015, 31(3): 240-243. doi: 10.3760/cma.j.issn.1005-1015.2015.03.007 Copy

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16.	张鹏, 王雨生, 胡丹, 等.561nm激光光凝治疗中心性浆液性脉络膜视网膜病变[J].眼科新进展, 2013, 33(3):263-265.
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1. 张鹏, 惠延年, 白建伟, 等.中心性浆液性脉络膜视网膜病变的吲哚青绿和荧光素血管造影[J].第四军医大学学报, 2001, 22(6):538-541.
2. 孟晓红, 张敏芳, 阴正勤, 等.中心性浆液性脉络膜视网膜病变眼底自身荧光的影像特征[J].中华眼底病杂志, 2007, 23(6):384-387.
3. 张鹏, 惠延年, 张自峰, 等.视网膜和视网膜色素上皮联合错构瘤的眼底影像特征[J].中华眼底病杂志, 2014, 30(6):554-557.
4. Kellner U, Kellner S, Weinitz S.Fundus autofluorescence(488 NM) and near-infrared autofluorescence(787 NM) visualize different retinal pigment epithelium alterations in patients with age-related macular degeneration[J].Retina, 2010(1), 30:6-15.
5. 马景学.视网膜病[M]//赵堪兴, 杨培增.眼科学.8版.北京:人民卫生出版社, 2013:219-221.
6. Sparrow JR, Duncker T.Fundus autofluorescence and RPE lipofuscin in age-related macular degeneration[J].J Clin Med, 2014, 3(4):1302-1321.
7. 孙怡雯, 屈军乐, 赵羚伶, 等.眼底视网膜色素上皮层细胞脂褐素及氧化黑色素自体荧光寿命成像研究[J].物理学报, 2008, 57(2):772-777.
8. Duncker T, Tabacaru MR, Lee W, et al.Comparison of near-infrared and short-wavelength autofluorescence in retinitis pigmentosa[J].Invest Ophthalmol Vis Sci, 2013, 54:585-591.
9. Kayatz P, Thumann G, Luther TT, et al. Oxidation causes melanin fluorescence[J].Invest Ophthalmol Vis Sci, 2001, 42(1):241-246.
10. Keilhauer CN, Delori FC.Near-infrared autofluorescence imaging of the fundus:visualization of ocular melanin[J].Invest Ophthalmol Vis Sci, 2006, 47(8):3556-3564.
11. Ramsey DJ, Sunness JS, Malviya P, et al.Automated image alignment and segmentation to follow progression of geographic atrophy in age-related macular degeneration[J].Retina, 2014, 34(7):1296-1307.
12. Ritter M, Zotter S, Schmidt WM, et al.Characterization of stargardt disease using polarization-sensitive optical coherence tomography and fundus autofluorescence imaging[J].Invest Ophthalmol Vis Sci, 2013, 54(9):6416-6425.
13. Duncker T, Lee W, Tsang SH, et al.Distinct characteristics of inferonasal fundus autofluorescence patterns in stargardt disease and retinitis pigmentosa[J].Invest Ophthalmol Vis Sci, 2013, 54(10):6820-6826.
14. Lindner E, Weinberger A, Kirschkamp T, et al.Near-infrared autofluorescence and indocyanine green angiography in central serous chorioretinopathy[J].Ophthalmologica, 2012, 227(1):34-38.
15. Matsumoto H, Kishi S, Sato T, et al.Fundus autofluorescence of elongated photoreceptor outer segments in central serous chorioretinopathy[J].Am J Ophthalmol, 2011, 151(4):617-623.
16. 张鹏, 王雨生, 胡丹, 等.561nm激光光凝治疗中心性浆液性脉络膜视网膜病变[J].眼科新进展, 2013, 33(3):263-265.
17. 李略, 李东辉, 场治坤, 等.中心性浆液性脉络膜视网膜病变眼底血管造影及脉络膜厚度分析[J].中华眼科杂志, 2012, 48(10):878-882.

Chinese Journal of Ocular Fundus Diseases

Observation on imaging features of two types of fundus autofluorescence and spectral-domain optical coherence tomography in acute central serous chorioretinopathy

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