The Impact of Mood on the Intrinsic Functional Connectivity_Journal of Biomedical Engineering

Authors：

WANGZicong , SONGSen ,  WANGLihong

Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing 100084, China;

Corresponding author：

WANGLihong, Email: lihong001@gmail.com

Keywords：

mood; resting-state functional connectivity; dorsolateral prefrontal cortex; functional magnetic resonance imaging

DOI：

10.7507/1001-5515.20140049

Video：

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Abstract Full text Figures/Tables Video References Cited by

Although a great number of studies have investigated the changes of resting-state functional connectivity (rsFC) in patients with mental disorders, such as depression and schizophrenia etc, little is known how stable the changes are, and whether temporal sad or happy mood can modulate the intrinsic rsFC. In our experiments, happy and sad video clips were used to induce temporally happy and sad mood states in 20 healthy young adults. We collected functional magnetic resonance imaging (fMRI) data while participants were watching happy or sad video clips, which were administrated in two consecutive days. Seed-based functional connectivity analyses were conducted using the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), and amygdala as seeds to investigate neural network related to executive function, attention, and emotion. We also investigated the association of the rsFC changes with emotional arousability level to understand individual differences. There is significantly stronger functional connectivity between the left DLPFC and posterior cingulate cortex (PCC) under sad mood than that under happy mood. The increased connectivity strength was positively correlated with subjects' emotional arousability. The increased positive correlation between the left DLPFC and PCC under sad relative to happy mood might reflect an increased processing of negative emotion-relevant stimuli. The easier one was induced by strong negative emotion (higher emotional arousability), the greater the left DLPFC-PCC connectivity was indicated, the greater the instability of the intrinsic rsFC was shown.

Citation： WANGZicong, SONGSen, WANGLihong. The Impact of Mood on the Intrinsic Functional Connectivity. Journal of Biomedical Engineering, 2014, 31(2): 262-266. doi: 10.7507/1001-5515.20140049 Copy

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14.	MAYBERG H S.Limbic-cortical dysregulation:a proposed model of depression[J].J Neuropsychiatry Clin Neurosci,1997,9(3):471-481.
15.	WANG L,LABAR K S,SMOSKI M,et al.Prefrontal mechanisms for executive control over emotional distraction are altered in major depression[J].Psychiatry Res,2008,163(2):143-155.
16.	BRAITHWAITE V A.The scale of emotional arousability:bridging the gap between the neuroticism construct and its measurement[J].Psychol Med,1987,17(1):217-225.
17.	WANG L,LABAR K S,MCCARTHY G.Mood alters amygdala activation to sad distractors during an attentional task[J].Biol Psychiatry,2006,60(10):1139-1146.
18.	LOWE M J,MOCK B J,SORENSON J A.Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations[J].Neuroimage,1998,7(2):119-132.
19.	HAGMANN P,CAMMOUN L,GIGANDET X,et al.Mapping the structural core of human cerebral cortex[J].PLoS Biol,2008,6(7):E159.
20.	LEECH R,BRAGA R,SHARP D J.Echoes of the brain within the posterior cingulate cortex[J].J Neurosci,2012,32(1):215-222.
21.	MADDOCK R J,BUONOCORE M H,KILE S J,et al.Brain regions showing increased activation by threat-related words in panic disorder[J].Neuroreport,2003,14(3):325-328.
22.	STRAUBE T,MENTZEL H J,GLAUER M,et al.Brain activation to phobia-related words in phobic subjects[J].Neurosci Lett,2004,372(3):204-208.
23.	CABEZA R,NYBERG L.Neural bases of learning and memory:functional neuroimaging evidence[J].Curr Opin Neurol,2000,13(4):415-421.
24.	MADDOCK R J,GARRETT A S,BUONOCORE M H.Posterior cingulate cortex activation by emotional words:fMRI evidence from a Valence decision task[J].Hum Brain Mapp,2003,18(1):30-41.
25.	MADDOCK R J.The retrosplenial cortex and emotion:new insights from functional neuroimaging of the human brain[J].Trends Neurosci,1999,22(7):310-316.

1. BISWAL B,YETKIN F Z,HAUGHTON V M,et al.Functional connectivity in the motor cortex of resting human brain using echo-planar MRI[J].Magn Reson Med,1995,34(4):537-541.
2. FRISTON K J,FRITH C D,LIDDLE P F,et al.Functional connectivity:the principal-component analysis of large (PET) data sets[J].J Cereb Blood Flow Metab,1993,13(1):5-14.
3. SRIDHARAN D,LEVITIN D J,MENON V.A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks[J].Proc Natl Acad Sci U S A,2008,105(34):12569-12574.
4. KOECHLIN E,SUMMERFIELD C.An information theoretical approach to prefrontal executive function[J].Trends Cogn Sci,2007,11(6):229-235.
5. SHELINE Y I,PRICE J L,YAN Z,et al.Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus[J].Proc Natl Acad Sci U S A,2010,107(24):11020-11025.
6. GUSNARD D A,AKBUDAK E,SHULMAN G L,et al.Medial prefrontal cortex and self-referential mental activity:relation to a default mode of brain function[J].Proc Natl Acad Sci U S A,2001,98(7):4259-4264.
7. GUSNARD D A,RAICHLE M E,RAICHLE M E.Searching for a baseline:functional imaging and the resting human brain[J].Nat Rev Neurosci,2001,2(10):685-694.
8. RAICHLE M E,MACLEOD A M,SNYDER A Z,et al.A default mode of brain function[J].Proc Natl Acad Sci U S A,2001,98(2):676-682.
9. LIANG M,ZHOU Y,JIANG T,et al.Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging[J].Neuroreport,2006,17(2):209-213.
10. ANAND A,LI Y,WANG Y,et al.Activity and connectivity of brain mood regulating circuit in depression:a functional magnetic resonance study[J].Biol Psychiatry,2005,57(10):1079-1088.
11. ANAND A,LI Y,WANG Y,et al.Resting state corticolimbic connectivity abnormalities in unmedicated bipolar disorder and unipolar depression[J].Psychiatry Res,2009,171(3):189-198.
12. SEELEY W W,MENON V,SCHATZBERG A F,et al.Dissociable intrinsic connectivity networks for salience processing and executive control[J].J Neurosci,2007,27(9):2349-2356.
13. WAITES A B,STANISLAVSKY A,ABBOTT D F,et al.Effect of prior cognitive state on resting state networks measured with functional connectivity[J].Hum Brain Mapp,2005,24(1):59-68.
14. MAYBERG H S.Limbic-cortical dysregulation:a proposed model of depression[J].J Neuropsychiatry Clin Neurosci,1997,9(3):471-481.
15. WANG L,LABAR K S,SMOSKI M,et al.Prefrontal mechanisms for executive control over emotional distraction are altered in major depression[J].Psychiatry Res,2008,163(2):143-155.
16. BRAITHWAITE V A.The scale of emotional arousability:bridging the gap between the neuroticism construct and its measurement[J].Psychol Med,1987,17(1):217-225.
17. WANG L,LABAR K S,MCCARTHY G.Mood alters amygdala activation to sad distractors during an attentional task[J].Biol Psychiatry,2006,60(10):1139-1146.
18. LOWE M J,MOCK B J,SORENSON J A.Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations[J].Neuroimage,1998,7(2):119-132.
19. HAGMANN P,CAMMOUN L,GIGANDET X,et al.Mapping the structural core of human cerebral cortex[J].PLoS Biol,2008,6(7):E159.
20. LEECH R,BRAGA R,SHARP D J.Echoes of the brain within the posterior cingulate cortex[J].J Neurosci,2012,32(1):215-222.
21. MADDOCK R J,BUONOCORE M H,KILE S J,et al.Brain regions showing increased activation by threat-related words in panic disorder[J].Neuroreport,2003,14(3):325-328.
22. STRAUBE T,MENTZEL H J,GLAUER M,et al.Brain activation to phobia-related words in phobic subjects[J].Neurosci Lett,2004,372(3):204-208.
23. CABEZA R,NYBERG L.Neural bases of learning and memory:functional neuroimaging evidence[J].Curr Opin Neurol,2000,13(4):415-421.
24. MADDOCK R J,GARRETT A S,BUONOCORE M H.Posterior cingulate cortex activation by emotional words:fMRI evidence from a Valence decision task[J].Hum Brain Mapp,2003,18(1):30-41.
25. MADDOCK R J.The retrosplenial cortex and emotion:new insights from functional neuroimaging of the human brain[J].Trends Neurosci,1999,22(7):310-316.

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The Impact of Mood on the Intrinsic Functional Connectivity

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