Research on Numerical Simulation of Temperature Distribution during Transcranial Tumor Therapy with High Intensity Focused Ultrasound_Journal of Biomedical Engineering

Authors：

ZHANGQian , WANGYizhe , ZHOUWenzheng , XUEFanfan ,  JIANXiqi

Department of Biomedical Engineering, Tianjin Medical University, Tianjin 300070, China;

Corresponding author：

JIANXiqi, Email: jianxiqi@tijmu.edu.cn

Keywords：

high-intensity focused ultrasound; transcranial therapy; temperature distribution

DOI：

10.7507/1001-5515.20140241

Video：

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Abstract Full text Figures/Tables Video References Cited by

Numerical simulation is one of the most significant methods to predict the temperature distribution in high-intensity focused ultrasound (HIFU) therapy. In this study, the adopted numerical simulation was used based on a transcranial ultrasound therapy model taking a human skull as a reference. The approximation of the Westervelt formula and the Pennes bio-heat conduction equation were applied to the simulation of the transcranial temperature distribution. According to the temperature distribution and the Time Reversal theory, the position of the treatable focal region was corrected and the hot spot existing in the skull was eliminated. Furthermore, the influence of the exposure time, input power and the distance between transducer and skull on the temperature distribution was analyzed. The results showed that the position of the focal region could be corrected and the hot spot was eliminated using the Time Reversal theory without affecting the focus. The focal region above 60℃ could be formed at the superficial tissue located from the skull of 20 mm using the hot spot elimination method and the volume of the focal region increases with the exposure time and the input power in a nonlinear form. When the same volume of the focal region was obtained, the more power was inputted, the less the exposure time was needed. Moreover, the volume of the focal region was influenced by the distance between the transducer and the skull.

Citation： ZHANGQian, WANGYizhe, ZHOUWenzheng, XUEFanfan, JIANXiqi. Research on Numerical Simulation of Temperature Distribution during Transcranial Tumor Therapy with High Intensity Focused Ultrasound. Journal of Biomedical Engineering, 2014, 31(6): 1272-1277. doi: 10.7507/1001-5515.20140241 Copy

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1. KENNEDY J E. High-intensity focused ultrasound in the treatment of solid tumours[J]. Nat Rev Cancer, 2005, 5(4):321-327.
2. LI J L, LIU X Z, ZHANG D, et al. Influence of ribs on the nonlinear sound field of therapeutic ultrasound[J]. Ultrasound Med Biol, 2007, 33(9):1413-1420.
3. QIAN Z W. Issues in clinical applications of high intensity focused ultrasound (HIFU)[J]. Curr Med Imaging Rev, 2010, 6(3):136-144.
4. SUN J, HYNYNEN K. Focusing of therapeutic ultrasound through a human skull:A numerical study[J]. J Acoust Soc Am, 1998, 104(3 Pt 1):1705-1715.
5. 卞伟,支兴刚,王智彪,等.高强度聚焦超声作用下兔脑的病理转归[J].重庆医科大学学报,2006,31(4):494-497,520.
6. AUBRY J F, TANTER M, PERNOT M, et al. Experimental demonstration of noninvasive transskull adaptive focusing based on prior computed tomography scans[J]. J Acoust Soc Am, 2003, 113(1):84-93.
7. PERNOT M, AUBRY J F, TANTER M, et al. Prediction of the skull overheating during high intensity focused ultrasound transcranial brain therapy[C]//2004 IEEE International Ultrasonics, Ferroelectrics, and Frequency Control Joint 50th Anniversary Conference. 2004, 2:1005-1008.
8. PINTON G, AUBRY J F, FINK M, et al. Effects of nonlinear ultrasound propagation on high intensity brain therapy[J]. Med Phys, 2011, 38(3):1207-1216.
9. MCDANNOLD N, CLEMENT G, BLACK P, et al. Transcranial MRI-guided focused ultrasound surgery of brain tumors:Initial findings in three patients[J]. Neurosurgery, 2010, 66(2):323-332.
10. 菅喜岐,孙武军.凹球面八圆环相控阵高强度聚焦换能器:中国,CN201020682474.6[P]. 2011-09-14.
11. 菅喜岐,李文龙,刘东顺,等.体外冲击波碎石焦点区域声压分布的时域有限差分仿真研究[J].现代生物医学进展,2008,8(1):122-125.
12. ROVE K O, SULLIVAN K F, CRAWFORD E D. High-intensity focused ultrasound:ready for primetime[J]. Urol Clin North Am, 2010, 37(1):27-35.
13. 孙武军,张弥左,李文龙,等.高强度聚焦超声换能器温度场的数值仿真[J].生物物理学报,2009,25(5):366-372.
14. PENNES H H. Analysis of tissue and arterial blood temperatures in the resting human forearm. 1948[J]. J Appl Physiol, 1998, 85(1):5-34.
15. HALLAJ I M, CLEVELAND R O. FDTD simulation of finite-amplitude pressure and temperature fields for biomedical ultrasound[J]. J Acoust Soc Am, 1999, 105(5):L7-12.
16. CLEMENT G T, WHITE P J, HYNYNEN K. Enhanced ultrasound transmission through the human skull using shear mode conversion[J]. J Acoust Soc Am, 2004, 115(3):1356-1364.
17. JING Y, MERAL F C, CLEMENT G T. Time-reversal transcranial ultrasound beam focusing using a k-space method[J]. Phys Med Biol, 2012, 57(4):901-917.
18. LEDUC N, OKITA K, SUGIYAMA K, et al. Focus control in HIFU therapy assisted by time-reversal simulation with an iterative procedure for hot spot elimination[J]. J Biomech Sci Engrg, 2012, 7(1):43-56.
19. CONNOR C W, HYNYNEN K. Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery[J]. IEEE Trans Biomed Eng, 2004, 51(10):1693-1706.

Journal of Biomedical Engineering

Research on Numerical Simulation of Temperature Distribution during Transcranial Tumor Therapy with High Intensity Focused Ultrasound

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