<i>In Situ</i> Polymerization and Characterization of Hydroxyapatite/polyurethane Implanted Material_Journal of Biomedical Engineering

Authors：

GUMuqing ,  XIAOFengjuan , LIANGYe , YUELin , LISong , LILanlan , FENGFeifei

School of Material Science and Engineering, Shijiazhuang Tiedao University, Shijiazhuang 050043, China;

Corresponding author：

XIAOFengjuan, Email: xfj66@126.com

Keywords：

hydroxyapatite; polyurethane; micro morphology; thermal stability; mechanical properties; biocompatibility

DOI：

10.7507/1001-5515.20150149

Video：

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In order to improve the interfacial bonding strength of hydroxyapatite/polyurethane implanted material and dispersion of hydroxyapatite in the polyurethane matrix, we in the present study synthesized nano-hydroxyapatite/polyurethane composites by in situ polymerization. We then characterized and analyzed the fracture morphology, thermal stability, glass transition temperature and mechanical properties. We seeded MG63 cells on composites to evaluate the cytocompatibility of the composites. In situ polymerization could improve the interfacial bonding strength, ameliorate dispersion of hydroxyapatite in the properties of the composites. After adding 20 wt% hydroxyapatite into the polyurethane, the thermal stability was improved and the glass transition temperatures were increased. The tensile strength and maximum elongation were 6.83 MPa and 861.17%, respectively. Compared with those of pure polyurethane the tensile strength and maximum elongation increased by 236.45% and 143.30%, respectively. The composites were helpful for cell adhesion and proliferation in cultivation.

Citation： GUMuqing, XIAOFengjuan, LIANGYe, YUELin, LISong, LILanlan, FENGFeifei. In Situ Polymerization and Characterization of Hydroxyapatite/polyurethane Implanted Material. Journal of Biomedical Engineering, 2015, 32(4): 826-831. doi: 10.7507/1001-5515.20150149 Copy

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1. CERRONI L,FILOCAMO R,FABBRI M,et al.Growth of osteoblast like cells on porous hydroxyapatite ceramics:an in vitro study[J].Biomed Eng,2002,19(2):119-124.
2. LI J D,ZUO Y,CHENG X M,et al.Novel bioactive nanohydroxyapatite/polyamide66 composite membrane for guided bone regeneration[J],Materials Research Innovations,2008,12(2);98-101.
3. 沈娟,金波,蒋琪英,等.羟基磷灰石/合成高分子复合材料的制备方法、性能及其应用研究进展[J].化工进展,2011,30(8):1749-1755.
4. JAVNI I,PETROVIC ZS,GUO A,et al.Thermal stability of polyurethanes based on vegetable oils[J].Journal of applied polymer science,2000,77(8):1723-1734.
5. KAVLOCK K,PECHAR T,HOLLINGER J,et al.Synthesis and characterization of segmented poly (esterurethane urea) elastomers for bone tissue engineering[J].Acta Biomaterialia,2007,3(4):475-484.
6. WERNER A,LECHNIAK Z,SKALSKI K,et al.Design and manufacture of anatomical hip joint endoprostheses using CAD/CAM systems[J].Journal of materials processing technology,2000,107(1):181-186.
7. 杜江华.羟基磷灰石/生物高分子复合材料的制备方法进展[J].中国组织工程研究与临床康复,2010,14(25):4717-4720.
8. 林岚云,刘榕芳,肖秀峰.羟基磷灰石涂层的生物仿生法研究进展[J].硅酸盐通报,2005,24(1):71-75.
9. 周成飞.聚氨酯微相分离研究及其主要进展[J].化工时刊,2012,26(12):20-25.
10. 甄建军,翟文.十八醇对TDI型聚氨酯弹性体耐热性能的影响[J].聚氨酯工业,2009,24(1):37-39.
11. 刘怀浩,张利,李吉东,等.纳米HA/PU复合材料的力学性能和热性能[J].复合材料学报,2010,27(3):61-66.
12. 江治,袁开军,李疏芬,等.聚氨酯的FTIR光谱与热分析研究[J].光谱学与光谱分析,2006,26(4):624-628.
13. 徐翔民,张予东,李宾杰,等.纳米SiO2/尼龙66复合材料的力学性能和热性能[J].复合材料学报,2008,25(4):56-61.
14. 徐翔民,张予东,李宾杰,等.尼龙66/SiO2纳米复合材料的界面结构及其对材料力学性能的影响[J].高分子材料科学与工程,2009,25(2):41-44.
15. JIE W,LI Y.Tissue engineering scaffold material of nanoapatite crystals and polyamide composite[J].European Polymer Journal,2004,40(3):509-515.

Journal of Biomedical Engineering

In Situ Polymerization and Characterization of Hydroxyapatite/polyurethane Implanted Material

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