Advances of Function of Prussian Blue Nano-materials in Cancer Diagnosis and Therapy_Journal of Biomedical Engineering

Authors：

JINXing , QUHaijing , ZHUChaojian , JINGLijia ,  YUTao

Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline-Alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040, China;

Corresponding author：

YUTao, Email: yutao@nefu.edu.cn

Keywords：

Prussian blue; nano-materials; tumor imaging; cancer treatment

DOI：

10.7507/1001-5515.20160191

Video：

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Prussian blue (PB), a kind of ferrous ferricyanide composed of Fe²⁺ and Fe³⁺, has been approved by Food and Drug Administration (FDA, USA) as an oral drug for the treatment of thallium and cesium poisoning. The biosafety of PB has been proved by long-term clinical trials. In recent years, PB nano-materials have attracted intensive research interests for medical application, especially for tumor imaging and treatment of cancer. Compared to other nano-materials, PB has potential advantage in medical application due to the high biosafety. This paper reviews the new advances in the functions of cancer diagnosis and therapy of PB nano-materials.

Citation： JINXing, QUHaijing, ZHUChaojian, JINGLijia, YUTao. Advances of Function of Prussian Blue Nano-materials in Cancer Diagnosis and Therapy. Journal of Biomedical Engineering, 2016, 33(6): 1209-1213. doi: 10.7507/1001-5515.20160191 Copy

1.	FINAS D, BAUMANN K, SYDOW L, et al. SPIO detection and distribution in biological tissue--a murine MPI-SLNB breast cancer model[J]. IEEE Trans Magn, 2015, 51(2): 5400104.
2.	董鸿瑞, 程虹,李泳,等.普鲁士蓝染色在肾活检病理诊断中的应用[J/CD].中华临床医师杂志,2012,6(20):6392-6394.
3.	VERZIJL J M, JOORE H C, VAN DIJK A, et al. In vitro cyanide release of four prussian blue salts used for the treatment of cesium contaminated persons[J]. J Toxicol Clin Toxicol, 1993, 31(4): 553-562.
4.	KAMERBEEK H H, RAUWS A G, TEN HAM M, et al. Prussian blue in therapy of thallotoxicosis. An experimental and clinical investigation[J]. Acta Med Scand, 1971, 189(4): 321-324.
5.	FU Guanglei, LIU Wei, LI Yanyan, et al. Magnetic Prussian blue nanoparticles for targeted photothermal therapy under magnetic resonance imaging guidance[J]. Bioconjug Chem, 2014, 25(9): 1655-1663.
6.	CAI Xiaojun, GAO Wei, MA Ming, et al. A Prussian blue-based core-shell hollow-structured mesoporous nanoparticle as a smart theranostic agent with ultrahigh pH-responsive longitudinal relaxivity[J]. Adv Mater, 2015, 27(41): 6382-6389.
7.	CHENG Liang, GONG Hua, ZHU Wenwen, et al. PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy[J]. Biomaterials, 2014, 35(37): 9844-9852.
8.	LIANG Xiaolong, DENG Zijian, JING Lijia, et al. Prussian blue nanoparticles operate as a contrast agent for enhanced photoacoustic imaging[J]. Chem Commun (Camb), 2013, 49(94): 11029-11031.
9.	WU Ming, WANG Qingtang, LIU Xiaolong, et al. Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma[J]. RSC Adv, 2015, 5(39): 30970-30980.
10.	SHOKOUHIMEHR M, SOEHNLEN E S, HAO J H, et al. Dual purpose Prussian blue nanoparticles for cellular imaging and drug delivery: a new generation of T1-weighted MRI contrast and small molecule delivery agents[J]. Mater Chem, 2010, 20(25): 5251-5259.
11.	HOFFMAN H A, CHAKRABARTI L, DUMONT M F, et al. Prussian blue nanoparticles for laser-induced photothermal therapy of tumors[J]. RSC Adv, 2014, 4(56): 29729-29734.
12.	DUMONT M F, YADAVILLI S, SZE R W, et al. Manganese-containing Prussian blue nanoparticles for imaging of pediatric brain tumors[J]. Int J Nanomedicine, 2014, 9: 2581-2595.
13.	LI Xiaoda, LIANG Xiaolong, MA Fang, et al. Chitosan stabilized Prussian blue nanoparticles for photothermally enhanced gene delivery[J]. Colloids Surf B Biointerfaces, 2014, 123: 629-638.
14.	ZHU Wenwen, LIU Kai, SUN Xiaoqi, et al. Mn²⁺-doped Prussian blue nanocubes for bimodal imaging and photothermal therapy with enhanced performance[J]. ACS Appl Mater Interfaces, 2015, 7(21): 11575-11582.
15.	FU Guanglei, LIU Wei, FENG Shanshan, et al. Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy[J]. Chem Commun (Camb), 2012, 48(94): 11567-11569.
16.	XUE Peng, BAO Jingnan, WU Yafeng, et al. Magnetic Prussian blue nanoparticles for combined enzyme-responsive drug release and photothermal therapy[J]. RSC Adv, 2015, 5(36): 28401-28409.
17.	LI Zhenglin, ZENG Yongyi, ZHANG Da, et al. Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma[J]. Journal of Materials Chemistry B, 2014, 2(23): 3686-3696.
18.	SHOKOUHIMEHR M, SOEHNLEN E S, KHITRIN A, et al. Biocompatible Prussian blue nanoparticles: preparation, stability, cytotoxicity, and potential use as an MRI contrast agent[J]. Inorg Chem Commun, 2010, 13(1): 58-61.
19.	刘伟. 透明质酸修饰的普鲁士蓝纳米粒子的制备及光热性能研究[D].哈尔滨:哈尔滨工业大学,2014.
20.	CAI Xiaojun, JIA Xiaoqing, GAO Wei, et al. A versatile nanotheranostic agent for efficient dual-mode imaging guided synergistic chemo-thermal tumor therapy[J]. Adv Funct Mater, 2015, 25(17): 2520-2529.
21.	JING Lijia, SHAO Shangmin, WANG Yang, et al. Hyaluronic acid modified hollow Prussian blue nanoparticles loading 10-hydroxycamptothecin for targeting thermochemotherapy of cancer[J]. Theranostics, 2016, 6(1): 40-53.
22.	ZAKARIA M B, BELIK A A, LIU C H, et al. Prussian blue derived nanoporous iron oxides as anticancer drug carriers for magnetic-guided chemotherapy[J]. Chem Asian J, 2015, 10(7): 1457-1462.
23.	JIA Xiaoqing, CAI Xiaojun, CHEN Yu, et al. Perfluoropentane-encapsulated hollow mesoporous Prussian blue nanocubes for activated ultrasound imaging and photothermal therapy of cancer[J]. ACS Appl Mater Interfaces, 2015, 7(8): 4579-4588.
24.	KANAZAKI K, SANO K, MAKINO A, et al. Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging[J]. Nanomedicine, 2015, 11(8): 2051-2060.
25.	WANG Guohao, ZHANG Fan, TIAN Rui, et al. Nanotubes-embedded indocyanine green-hyaluronic acid nanoparticles for photoacoustic-imaging-guided phototherapy[J]. ACS Appl Mater Interfaces, 2016, 8(8): 5608-5617.
26.	JING Lijia, LIANG Xiaolong, DENG Zijian, et al. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer[J]. Biomaterials, 2014, 35(22): 5814-5821.
27.	ZHONG H X, WEI Y, YUE Y Z, et al. Preparation of core-shell Ag@CeO₂ nanocomposite by LSPR photothermal induced interface reaction[J]. Nanotechnilogy, 2016, 27(13): 135701.
28.	ZHA Zhengbao, ZHANG Shuhai, DENG Zijian, et al. Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy[J]. Chem Commun (Camb), 2013, 49(33): 3455-3457.
29.	YANG X Y, ZHOU Z G, WANG L, et al. Folate conjugated Mn₃O₄@SiO₂ nanoparticles for targeted magnetic resonance imaging in vivo[J]. Mater Res Bull, 2014, 57: 97-102.
30.	HU He, DAI Antao, SUN Jin, et al. Aptamer-conjugated Mn₃O₄@SiO₂ core-shell nanoprobes for targeted magnetic resonance imaging[J]. Nanoscale, 2013, 5(21): 10447-10454.
31.	DU Bin, CAO Xiaohui, ZHAO Feifei, et al. Multimodal imaging-guided, dual-targeted photothermal therapy for cancer[J]. Journal of Materials Chemistry B, 2016, 4(11): 2038-2050.
32.	LI Zhenglin, HU Ying, JIANG Tingting, et al. Human-serum-albumin-coated Prussian blue nanoparticles as pH-/thermotriggered drug-delivery vehicles for cancer thermochemotherapy[J]. Part Part Syst Charact, 2016, 33(1): 53-62.

1. FINAS D, BAUMANN K, SYDOW L, et al. SPIO detection and distribution in biological tissue--a murine MPI-SLNB breast cancer model[J]. IEEE Trans Magn, 2015, 51(2): 5400104.
2. 董鸿瑞, 程虹,李泳,等.普鲁士蓝染色在肾活检病理诊断中的应用[J/CD].中华临床医师杂志,2012,6(20):6392-6394.
3. VERZIJL J M, JOORE H C, VAN DIJK A, et al. In vitro cyanide release of four prussian blue salts used for the treatment of cesium contaminated persons[J]. J Toxicol Clin Toxicol, 1993, 31(4): 553-562.
4. KAMERBEEK H H, RAUWS A G, TEN HAM M, et al. Prussian blue in therapy of thallotoxicosis. An experimental and clinical investigation[J]. Acta Med Scand, 1971, 189(4): 321-324.
5. FU Guanglei, LIU Wei, LI Yanyan, et al. Magnetic Prussian blue nanoparticles for targeted photothermal therapy under magnetic resonance imaging guidance[J]. Bioconjug Chem, 2014, 25(9): 1655-1663.
6. CAI Xiaojun, GAO Wei, MA Ming, et al. A Prussian blue-based core-shell hollow-structured mesoporous nanoparticle as a smart theranostic agent with ultrahigh pH-responsive longitudinal relaxivity[J]. Adv Mater, 2015, 27(41): 6382-6389.
7. CHENG Liang, GONG Hua, ZHU Wenwen, et al. PEGylated Prussian blue nanocubes as a theranostic agent for simultaneous cancer imaging and photothermal therapy[J]. Biomaterials, 2014, 35(37): 9844-9852.
8. LIANG Xiaolong, DENG Zijian, JING Lijia, et al. Prussian blue nanoparticles operate as a contrast agent for enhanced photoacoustic imaging[J]. Chem Commun (Camb), 2013, 49(94): 11029-11031.
9. WU Ming, WANG Qingtang, LIU Xiaolong, et al. Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma[J]. RSC Adv, 2015, 5(39): 30970-30980.
10. SHOKOUHIMEHR M, SOEHNLEN E S, HAO J H, et al. Dual purpose Prussian blue nanoparticles for cellular imaging and drug delivery: a new generation of T1-weighted MRI contrast and small molecule delivery agents[J]. Mater Chem, 2010, 20(25): 5251-5259.
11. HOFFMAN H A, CHAKRABARTI L, DUMONT M F, et al. Prussian blue nanoparticles for laser-induced photothermal therapy of tumors[J]. RSC Adv, 2014, 4(56): 29729-29734.
12. DUMONT M F, YADAVILLI S, SZE R W, et al. Manganese-containing Prussian blue nanoparticles for imaging of pediatric brain tumors[J]. Int J Nanomedicine, 2014, 9: 2581-2595.
13. LI Xiaoda, LIANG Xiaolong, MA Fang, et al. Chitosan stabilized Prussian blue nanoparticles for photothermally enhanced gene delivery[J]. Colloids Surf B Biointerfaces, 2014, 123: 629-638.
14. ZHU Wenwen, LIU Kai, SUN Xiaoqi, et al. Mn²⁺-doped Prussian blue nanocubes for bimodal imaging and photothermal therapy with enhanced performance[J]. ACS Appl Mater Interfaces, 2015, 7(21): 11575-11582.
15. FU Guanglei, LIU Wei, FENG Shanshan, et al. Prussian blue nanoparticles operate as a new generation of photothermal ablation agents for cancer therapy[J]. Chem Commun (Camb), 2012, 48(94): 11567-11569.
16. XUE Peng, BAO Jingnan, WU Yafeng, et al. Magnetic Prussian blue nanoparticles for combined enzyme-responsive drug release and photothermal therapy[J]. RSC Adv, 2015, 5(36): 28401-28409.
17. LI Zhenglin, ZENG Yongyi, ZHANG Da, et al. Glypican-3 antibody functionalized Prussian blue nanoparticles for targeted MR imaging and photothermal therapy of hepatocellular carcinoma[J]. Journal of Materials Chemistry B, 2014, 2(23): 3686-3696.
18. SHOKOUHIMEHR M, SOEHNLEN E S, KHITRIN A, et al. Biocompatible Prussian blue nanoparticles: preparation, stability, cytotoxicity, and potential use as an MRI contrast agent[J]. Inorg Chem Commun, 2010, 13(1): 58-61.
19. 刘伟. 透明质酸修饰的普鲁士蓝纳米粒子的制备及光热性能研究[D].哈尔滨:哈尔滨工业大学,2014.
20. CAI Xiaojun, JIA Xiaoqing, GAO Wei, et al. A versatile nanotheranostic agent for efficient dual-mode imaging guided synergistic chemo-thermal tumor therapy[J]. Adv Funct Mater, 2015, 25(17): 2520-2529.
21. JING Lijia, SHAO Shangmin, WANG Yang, et al. Hyaluronic acid modified hollow Prussian blue nanoparticles loading 10-hydroxycamptothecin for targeting thermochemotherapy of cancer[J]. Theranostics, 2016, 6(1): 40-53.
22. ZAKARIA M B, BELIK A A, LIU C H, et al. Prussian blue derived nanoporous iron oxides as anticancer drug carriers for magnetic-guided chemotherapy[J]. Chem Asian J, 2015, 10(7): 1457-1462.
23. JIA Xiaoqing, CAI Xiaojun, CHEN Yu, et al. Perfluoropentane-encapsulated hollow mesoporous Prussian blue nanocubes for activated ultrasound imaging and photothermal therapy of cancer[J]. ACS Appl Mater Interfaces, 2015, 7(8): 4579-4588.
24. KANAZAKI K, SANO K, MAKINO A, et al. Development of anti-HER2 fragment antibody conjugated to iron oxide nanoparticles for in vivo HER2-targeted photoacoustic tumor imaging[J]. Nanomedicine, 2015, 11(8): 2051-2060.
25. WANG Guohao, ZHANG Fan, TIAN Rui, et al. Nanotubes-embedded indocyanine green-hyaluronic acid nanoparticles for photoacoustic-imaging-guided phototherapy[J]. ACS Appl Mater Interfaces, 2016, 8(8): 5608-5617.
26. JING Lijia, LIANG Xiaolong, DENG Zijian, et al. Prussian blue coated gold nanoparticles for simultaneous photoacoustic/CT bimodal imaging and photothermal ablation of cancer[J]. Biomaterials, 2014, 35(22): 5814-5821.
27. ZHONG H X, WEI Y, YUE Y Z, et al. Preparation of core-shell Ag@CeO₂ nanocomposite by LSPR photothermal induced interface reaction[J]. Nanotechnilogy, 2016, 27(13): 135701.
28. ZHA Zhengbao, ZHANG Shuhai, DENG Zijian, et al. Enzyme-responsive copper sulphide nanoparticles for combined photoacoustic imaging, tumor-selective chemotherapy and photothermal therapy[J]. Chem Commun (Camb), 2013, 49(33): 3455-3457.
29. YANG X Y, ZHOU Z G, WANG L, et al. Folate conjugated Mn₃O₄@SiO₂ nanoparticles for targeted magnetic resonance imaging in vivo[J]. Mater Res Bull, 2014, 57: 97-102.
30. HU He, DAI Antao, SUN Jin, et al. Aptamer-conjugated Mn₃O₄@SiO₂ core-shell nanoprobes for targeted magnetic resonance imaging[J]. Nanoscale, 2013, 5(21): 10447-10454.
31. DU Bin, CAO Xiaohui, ZHAO Feifei, et al. Multimodal imaging-guided, dual-targeted photothermal therapy for cancer[J]. Journal of Materials Chemistry B, 2016, 4(11): 2038-2050.
32. LI Zhenglin, HU Ying, JIANG Tingting, et al. Human-serum-albumin-coated Prussian blue nanoparticles as pH-/thermotriggered drug-delivery vehicles for cancer thermochemotherapy[J]. Part Part Syst Charact, 2016, 33(1): 53-62.

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