Analysis of mechanism of transition zones among β, δ and γ dispersions in brain white matter and grey matter_Journal of Biomedical Engineering

Authors：

TIAN Rui ,  LU Mai

Key Lab of Optoelectronic Technology and Intelligent Control, Ministry of Education, Lanzhou Jiaotong University, Lanzhou 730070, P.R.China;

Corresponding author：

LU Mai, Email: mai.lu@hotmail.com

Keywords：

polarization mechanism; dispersion properties; brain tissue; transition zone

DOI：

10.7507/1001-5515.201606051

Video：

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In order to explore the application of the dielectric properties of white matter and grey matter in β, δ and γ dispersion transition zones used in clinical medicine and microwave imaging technology, we calculated the dielectric constant and its increment by using Cole-Cole equation. Based on the mutation of the increment of dielectric constant, the frequency range of three dispersions were evaluated. The dominate dispersion and the corresponding polarization mechanism were analyzed by using Cole-Cole circle. The results showed that there are 3 transition zones in brain white matter, which occur between β and δ dispersion, δ and γ dispersion and β and γ dispersion respectively. In grey matter, there are only 2 transition zones, which are between β and δ dispersion and δ and γ dispersion respectively. By comparing the frequency range of white matter and grey matter, the frequency range in white matter is broader than that in grey matter for the transition zone of β and δ dispersion with the β dispersion occupying dominate position in both tissues, and the corresponding polarization mechanism is interfacial polarization. For the transition zone of δ and γ dispersion, the frequency range in white matter is also broader than that in grey matter with the δ dispersion occupying dominate position in both tissues, and the corresponding polarization mechanism is orientation polarization. This study can provide basic theory and reference for diagnosis of brain diseases and microwave imaging technology.

Citation： TIAN Rui, LU Mai. Analysis of mechanism of transition zones among β, δ and γ dispersions in brain white matter and grey matter. Journal of Biomedical Engineering, 2017, 34(4): 606-613. doi: 10.7507/1001-5515.201606051 Copy

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2.	方云, 汤治元, 张倩, 等. 人肝癌细胞电阻抗特性的实验研究. 生物医学工程学杂志, 2014(5): 1070-1074.
3.	徐桂芝, 王明时, 杨庆新, 等. 基于 EIT 技术颅内电阻抗特性分析. 中国生物医学工程学报, 2005, 24(6): 705-708.
4.	王洁然, 王化祥, 徐晓. 人体肺部组织介电特性实验研究. 中国生物医学工程学报, 2013, 32(2): 178-183.
5.	蔡占秀, 史学涛, 王廷, 等. 正常乳腺脂肪与腺体组织介电特性研究. 医疗卫生装备, 2012, 33(5): 1-3.
6.	Lu Mai, Ueno S. Comparison of specific absorption rate induced in brain tissues of a child and an adult using Mobile phone. J Appl Phys, 2012, 111(7): 07B311-07B313.
7.	Lu Mai, Ueno S. Computational study toward deep transcranial magnetic stimulation using coaxial circular coils. IEEE Trans Biomed Eng, 2015, 62(12): 2911-2919.
8.	Schwan H P. Electrical properties of tissues and cell suspensions. Adv Biol Med Phys, 1957, 5: 147-209.
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11.	Foster K R, Schepps J L, Schwan H P. Microwave dielectric relaxation in muscle. A second look. Biophys J, 1980, 29(2): 271-281.
12.	Foster K R, Schwan H P. Dielectric properties of tissues and biological materials: a critical review. Crit Rev Biomed Eng, 1989, 17(1): 25-104.
13.	赵孔双. 介电谱方法及应用. 北京: 北京化学工业出版社, 2008: 1-322.
14.	Schwan H P, Foster K R. Microwave dielectric properties of tissue. Some comments on the rotational mobility of tissue water.Biophys J, 1977, 17(2): 193-197.
15.	宋涛, 霍小林, 吴石增. 生物电磁特性及其应用. 北京: 北京工业大学出版社, 2008: 1-389.
16.	Foster K R, Schepps J L, Stoy R D, et al. Dielectric properties of brain tissue between 0.01 and 10 GHz. Phys Med Biol, 1979, 24(6): 1177-1187.
17.	Monai H, Inoue M, Miyakawa H, et al. Low-frequency dielectric dispersion of brain tissue due to electrically long neurites. Phys Rev E Stat Nonlin Soft Matter Phys, 2012, 86(6 Pt 1): 061911.
18.	吴小明, 董秀珍, 秦明新. 人大脑组织复电阻抗频率特性及其等效电路模型. 中国临床康复, 2005, 9(24): 244-246.
19.	田瑞, 逯迈, 陈小强, 等. 人脑白质与灰质色散和色散过渡区分析. 航天医学与医学工程, 2015, 28(3): 212-217.
20.	Cole K S, Cole R H. Dispersion and absorption in dielectrics: alternating current characteristics. Chem Phys, 1941, 9(4): 341-351.
21.	Gabriel S, Lau R W. Gabriel C. The Dielectric Properties of Biological Tissues: III. Parametric Models for the dielectric spectrum of tissues. Phys Med Biol, 1996, 41(11): 2271-2293.
22.	Schwan H P. Electrical properties of blood and its constituents: alternating current spectroscopy. Ann Hematol, 1983, 46(4): 185-197.
23.	Wei Y Z, Sridhar S. A new graphical representation for dielectric data. Chem Phys, 1993, 99(4): 3119-3312.
24.	田瑞, 逯迈. 生物肌肉组织 δ 色散机理. 兰州大学学报:自然科学版, 2016, 52(6): 850-854.

1. 徐灿华, 董秀珍. 生物电阻抗断层成像技术及其临床研究进展. 高电压技术, 2014, 40(12): 3738-3745.
2. 方云, 汤治元, 张倩, 等. 人肝癌细胞电阻抗特性的实验研究. 生物医学工程学杂志, 2014(5): 1070-1074.
3. 徐桂芝, 王明时, 杨庆新, 等. 基于 EIT 技术颅内电阻抗特性分析. 中国生物医学工程学报, 2005, 24(6): 705-708.
4. 王洁然, 王化祥, 徐晓. 人体肺部组织介电特性实验研究. 中国生物医学工程学报, 2013, 32(2): 178-183.
5. 蔡占秀, 史学涛, 王廷, 等. 正常乳腺脂肪与腺体组织介电特性研究. 医疗卫生装备, 2012, 33(5): 1-3.
6. Lu Mai, Ueno S. Comparison of specific absorption rate induced in brain tissues of a child and an adult using Mobile phone. J Appl Phys, 2012, 111(7): 07B311-07B313.
7. Lu Mai, Ueno S. Computational study toward deep transcranial magnetic stimulation using coaxial circular coils. IEEE Trans Biomed Eng, 2015, 62(12): 2911-2919.
8. Schwan H P. Electrical properties of tissues and cell suspensions. Adv Biol Med Phys, 1957, 5: 147-209.
9. Schwan H P. Analysis of dielectric data: experience gained with biological materials. IEEE Trans Electr Insul, 1985, 20(6): 913-922.
10. Gabriel C, Gabri E S, Corthout E. The dielectric properties of biological tissues: I. Literature survey. Phys Med Biol, 1996, 41(11): 2231-2249.
11. Foster K R, Schepps J L, Schwan H P. Microwave dielectric relaxation in muscle. A second look. Biophys J, 1980, 29(2): 271-281.
12. Foster K R, Schwan H P. Dielectric properties of tissues and biological materials: a critical review. Crit Rev Biomed Eng, 1989, 17(1): 25-104.
13. 赵孔双. 介电谱方法及应用. 北京: 北京化学工业出版社, 2008: 1-322.
14. Schwan H P, Foster K R. Microwave dielectric properties of tissue. Some comments on the rotational mobility of tissue water.Biophys J, 1977, 17(2): 193-197.
15. 宋涛, 霍小林, 吴石增. 生物电磁特性及其应用. 北京: 北京工业大学出版社, 2008: 1-389.
16. Foster K R, Schepps J L, Stoy R D, et al. Dielectric properties of brain tissue between 0.01 and 10 GHz. Phys Med Biol, 1979, 24(6): 1177-1187.
17. Monai H, Inoue M, Miyakawa H, et al. Low-frequency dielectric dispersion of brain tissue due to electrically long neurites. Phys Rev E Stat Nonlin Soft Matter Phys, 2012, 86(6 Pt 1): 061911.
18. 吴小明, 董秀珍, 秦明新. 人大脑组织复电阻抗频率特性及其等效电路模型. 中国临床康复, 2005, 9(24): 244-246.
19. 田瑞, 逯迈, 陈小强, 等. 人脑白质与灰质色散和色散过渡区分析. 航天医学与医学工程, 2015, 28(3): 212-217.
20. Cole K S, Cole R H. Dispersion and absorption in dielectrics: alternating current characteristics. Chem Phys, 1941, 9(4): 341-351.
21. Gabriel S, Lau R W. Gabriel C. The Dielectric Properties of Biological Tissues: III. Parametric Models for the dielectric spectrum of tissues. Phys Med Biol, 1996, 41(11): 2271-2293.
22. Schwan H P. Electrical properties of blood and its constituents: alternating current spectroscopy. Ann Hematol, 1983, 46(4): 185-197.
23. Wei Y Z, Sridhar S. A new graphical representation for dielectric data. Chem Phys, 1993, 99(4): 3119-3312.
24. 田瑞, 逯迈. 生物肌肉组织 δ 色散机理. 兰州大学学报:自然科学版, 2016, 52(6): 850-854.

Journal of Biomedical Engineering

Analysis of mechanism of transition zones among β, δ and γ dispersions in brain white matter and grey matter

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