An optical coherent imaging system for measuring the strain of blood vessels_Journal of Biomedical Engineering

Authors：

WU Kun , PENG Yuanlai , SHENG Guangji , LI Ang ,  LIU Xiao , DENG Xiaoyan , FAN Yubo

Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, P.R.China;

Corresponding author：

LIU Xiao, Email: liuxiao@buaa.edu.cn

Keywords：

blood vessel; strain; optical coherence tomography

DOI：

10.7507/1001-5515.201607011

Video：

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We aimed to establish an optical coherence tomography (OCT) system to measure the strain of blood vessels. A general OCT system was constructed firstly and its reliability was confirmed by comparing the OCT imaging of the porcine coronary and the corresponding histological slices. The strain of the porcine coronary was induced by static flow pressure and correlation algorithm was used to calculate the strain field of blood vessels within OCT images. The results suggest that bright-dark stratification of blood vessels displayed in OCT images is consistent with the intima and media layers of histological image. Furthermore, the strain of media layer is greater than that of the intima layer under the same static pressure. The optical coherence imaging system could not only measure the histological structure of the blood vessels, but also qualify the vessel strain under flow pressure.

Citation： WU Kun, PENG Yuanlai, SHENG Guangji, LI Ang, LIU Xiao, DENG Xiaoyan, FAN Yubo. An optical coherent imaging system for measuring the strain of blood vessels. Journal of Biomedical Engineering, 2017, 34(5): 772-777. doi: 10.7507/1001-5515.201607011 Copy

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21.	朱英, 邓又斌, 毕小军, 等. 超声二维应变技术评价动脉粥样硬化颈动脉壁弹性. 中国医学影像技术, 2008, 24(9): 1379-1381.0.
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23.	李仰梅, 李俊博, 崔崤峣, 等. 基于血管内高频超声的血管壁组织应变成像及弹性重构. 生物物理学报, 2001, 17(3): 513-521.0.
24.	Amundsen B H, Helle-Valle T, Edvardsen T, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol, 2006, 47(4): 789-793.
25.	Mahnkopf C, Badger T J, Burgon N S, et al. Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: implications for disease progression and response to catheter ablation. Heart Rhythm, 2010, 7(10): 1475-1481.

1. Holzapfel G A, Gasser T C, Ogden R W. Comparison of a multi-layer structural model for arterial walls with a fung-type model, and issues of material stability. J Biomech Eng, 2004, 126(2): 264-275.
2. Hove J R, Köster R W, Forouhar A S, et al. Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis. Nature, 2003, 421(6919): 172-177.
3. Lucitti J L, Jones E A, Huang Chengqun, et al. Vascular remodeling of the mouse yolk sac requires hemodynamic force. Development, 2007, 134(18): 3317-3326.
4. Holzapfel G A, Gasser T C, Ogden R W. A new constitutive framework for arterial wall mechanics and a comparative study of material models. Journal of Elasticity and the Physical Science of Solids, 2000, 61(1/3): 1-48.
5. Parker K J, Doyley M M, Rubens D J. Imaging the elastic properties of tissue: the 20 year perspective. Phys Med Biol, 2011, 56(1): R1-R29.
6. Manduca A, Oliphant T E, Dresner M A, et al. Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal, 2001, 5(4): 237-254.
7. Arridge S R. Optical tomography in medical imaging. Inverse Probl, 1999, 15(2): R41-R93.
8. Charonko J, Karri S, Schmieg J, et al. <italic>In vitro</italic> comparison of the effect of stent configuration on wall shear stress using time-resolved particle image velocimetry. Ann Biomed Eng, 2010, 38(3): 889-902.
9. Korshunov V A, Schwartz S M, Berk B C. Vascular remodeling. Arterioscler Thromb Vasc Biol, 2007, 27(8): 1722-1728.
10. De Korte C L, Van Der Steen A F W. Intravascular ultrasound elastography: an overview. Ultrasonics, 2002, 40(1): 859-865.
11. Jang I K, Bouma B E, Kang D H, et al. Visualization of coronary atherosclerotic plaques in patients using optical coherence tomography: comparison with intravascular ultrasound. J Am Coll Cardiol, 2002, 39(4): 604-609.
12. Fercher A F, Drexler W, Hitzenberger C K, et al. Optical coherence tomography-principles and applications. Reports on Progress in Physics, 2003, 66(2): 239.
13. Fujimoto J G, Brezinski M E, Tearney G J, et al. Optical biopsy and imaging using optical coherence tomography. Nat Med, 1995, 1(9): 970-972.
14. Sun C, Standish B, Yang V X. Optical coherence elastography: current status and future applications. J Biomed Opt, 2011, 16(4): 043001.
15. Regueira T, Bänziger B, Djafarzadeh S, et al. Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Critical Care, 2008, 12(4): R88.
16. 王满贵, 宋志宙. HE 染色切片的技术操作规范. 大同医学专科学校学报, 2004, 24(2): 21, 25.0.
17. 黄炳杰, 步鹏, 王向朝, 等. 用于频域光学相干层析成像的深度分辨色散补偿方法. 光学学报, 2012, 32(2): 200-2050.
18. Jiang I K. Cardiovascular OCT imaging. Springer International Publishing, 2015.
19. Schmitt J. OCT elastography: imaging microscopic deformation and strain of tissue. Opt Express, 1998, 3(6): 199-211.
20. Korinek J, Wang J W, Sengupta P P, et al. Two-dimensional strain-a Doppler-independent ultrasound method for quantitation of regional deformation: Validation in vitro and in vivo. Journal of the American Society of Echocardiography, 2005, 18(12): 1247-1253.
21. 朱英, 邓又斌, 毕小军, 等. 超声二维应变技术评价动脉粥样硬化颈动脉壁弹性. 中国医学影像技术, 2008, 24(9): 1379-1381.0.
22. Xie J, Zhou J, Fung Y C. Bending of blood vessel wall: stress-strain laws of the intima-media and adventitial layers. J Biomech Eng, 1995, 117(1): 136-145.
23. 李仰梅, 李俊博, 崔崤峣, 等. 基于血管内高频超声的血管壁组织应变成像及弹性重构. 生物物理学报, 2001, 17(3): 513-521.0.
24. Amundsen B H, Helle-Valle T, Edvardsen T, et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol, 2006, 47(4): 789-793.
25. Mahnkopf C, Badger T J, Burgon N S, et al. Evaluation of the left atrial substrate in patients with lone atrial fibrillation using delayed-enhanced MRI: implications for disease progression and response to catheter ablation. Heart Rhythm, 2010, 7(10): 1475-1481.

Journal of Biomedical Engineering

An optical coherent imaging system for measuring the strain of blood vessels

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