Current progress in neuroimaging research on treatment resistant depression_Journal of Biomedical Engineering

Authors：

PENG Wei ^1,3 ,  JIA Zhiyun ² , GONG Qiyong ¹

1. Huaxi Magnetic Resonance Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;
2. Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, P.R.China;
3. Department of Radiology, People’s Hospital of Deyang City, Deyang, Sichuan 618000, P.R.China;

Corresponding author：

Keywords：

treatment resistant depression; fronto-limbic system; brain structure; brain function; brain metabolism

DOI：

10.7507/1001-5515.201705086

Video：

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Depression is a common psychiatric disorder, and approximately 30% patients with depression do not respond effectively to standard antidepressant medication; this condition is termed treatment resistant depression (TRD) and its neurobiological mechanism remains unclear. Neuroimaging techniques can non-invasively explore changes in brain structure, function and metabolism. These techniques have been applied in neurobiological research of TRD and revealed critical abnormalities in brain structure, function and metabolism in fronto-limbic system. In this paper, we reviewed the latest progress in neuroimaging researches on TRD, providing new insight and imaging evidence for further neurobiological studies of TRD.

Citation： PENG Wei, JIA Zhiyun, GONG Qiyong. Current progress in neuroimaging research on treatment resistant depression. Journal of Biomedical Engineering, 2018, 35(5): 794-798. doi: 10.7507/1001-5515.201705086 Copy

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4.	Machino A, Kunisato Y, Matsumoto T, et al. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study. J Affect Disord, 2014, 168: 229-235.
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7.	van Eijndhoven P, Mulders P, Kwekkeboom L, et al. Bilateral ECT induces bilateral increases in regional cortical thickness. Transl Psychiatry, 2016, 6(8): e874.
8.	Guo Wenbin, Liu Feng, Chen Jindong, et al. Altered white matter integrity of forebrain in treatment-resistant depression: A diffusion tensor imaging study with tract-based spatial statistics. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 38(2): 201-206.
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10.	Peng Hongjun, Zheng Huirong, Ning Yuping, et al. Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study. BMC Psychiatry, 2013, 13: 72.
11.	Murrough J W, Collins K A, Fields J, et al. Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder. Transl Psychiatry, 2015, 5: e509.
12.	Johnston B A, Tolomeo S, Gradin V A, et al. Failure of hippocampal deactivation during loss events in treatment-resistant depression. Brain, 2015, 138(Pt 9): 2766-2776.
13.	Yamamura T, Okamoto Y, Okada G, et al. Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations. Transl Psychiatry, 2016, 6: e754.
14.	Guo W B, Liu F, Xue Z M, et al. Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: a resting-state fMRI study. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 37(1): 153-160.
15.	Guo W B, Liu F, Chen J D, et al. Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: a resting-state fMRI study. J Psychiatr Res, 2012, 46(10): 1366-1373.
16.	Cheng W, Rolls E T, Qiu J, et al. Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain, 2016, 139(12): 3296-3309.
17.	He Zongling, Cui Qian, Zheng Junjie, et al. Frequency-specific alterations in functional connectivity in treatment-resistant and -sensitive major depressive disorder. J Psychiatr Res, 2016, 82: 30-39.
18.	Guo Wenbin, Liu Feng, Xue Zhimin, et al. Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 44: 51-57.
19.	Lefebvre D, Langevin L M, Jaworska N A, et al. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression. J Affect Disord, 2017, 207: 110-113.
20.	Yang Xiaoru, Langevin L M, Jaworska N, et al. Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression. Psychiatry Clin Neurosci, 2016, 70(7, SI): 269-277.
21.	Li C T, Su T P, Wang S J, et al. Prefrontal glucose metabolism in medication-resistant major depression. Br J Psychiatry, 2015, 206(4): 316-323.
22.	Peng Wei, Chen Ziqi, Yin Li, et al. Essential brain structural alterations in major depressive disorder: A voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord, 2016, 199: 114-123.
23.	Gong Qiyong, He Yong. Depression, neuroimaging and connectomics: a selective overview. Biol Psychiatry, 2015, 77(3): 223-235.
24.	Zhang Huawei, Chen Ziqi, Jia Zhiyun, et al. Dysfunction of neural circuitry in depressive patients with suicidal behaviors: a review of structural and functional neuroimaging studies. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 53: 61-66.
25.	Jia Zhiyun, Wang Yuqing, Huang Xiaoqi, et al. Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T. J Psychiatry Neurosci, 2014, 39(3): 170-177.
26.	Baeken C, Marinazzo D, Wu Guorong, et al. Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity. World J Biol Psychiatry, 2014, 15(4): 286-297.
27.	Yang Xiaoru, Kirton A, Wilkes T C, et al. Glutamate alterations associated with transcranial magnetic stimulation in youth depression a case series. J ECT, 2014, 30(3): 242-247.
28.	邓佳慧, 李素霞, 董问天, 等. 难治性抑郁症发病机制的研究进展. 中国神经精神疾病杂志, 2014, 40(2): 123-126.

1. Otte C, Gold S M, Penninx B W, et al. Major depressive disorder. Nat Rev Dis Primers, 2016, 2: 16065.
2. Lui S, Zhou X J, Sweeney J A, et al. Psychoradiology: The frontier of neuroimaging in psychiatry. Radiology, 2016, 281(2): 357-372.
3. Serra-Blasco M, Portella M J, Gomez-Anson B A, et al. Effects of illness duration and treatment resistance on grey matter abnormalities in major depression. Br J Psychiatry, 2013, 202(6): 434-440.
4. Machino A, Kunisato Y, Matsumoto T, et al. Possible involvement of rumination in gray matter abnormalities in persistent symptoms of major depression: An exploratory magnetic resonance imaging voxel-based morphometry study. J Affect Disord, 2014, 168: 229-235.
5. Abdallah C G, Jackowski A, Sato J R, et al. Prefrontal cortical GABA abnormalities are associated with reduced hippocampal volume in major depressive disorder. Eur Neuropsychopharmacol, 2015, 25(8): 1082-1090.
6. Phillips J L, Batten L A, Tremblay P A, et al. A prospective, longitudinal study of the effect of remission on cortical thickness and hippocampal volume in patients with Treatment-Resistant depression. Int J Neuropsychopharmacol, 2015, 18(8): pyv037.
7. van Eijndhoven P, Mulders P, Kwekkeboom L, et al. Bilateral ECT induces bilateral increases in regional cortical thickness. Transl Psychiatry, 2016, 6(8): e874.
8. Guo Wenbin, Liu Feng, Chen Jindong, et al. Altered white matter integrity of forebrain in treatment-resistant depression: A diffusion tensor imaging study with tract-based spatial statistics. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 38(2): 201-206.
9. de Diego-Adelino J, Pires P, Gomez-Anson B, et al. Microstructural white-matter abnormalities associated with treatment resistance, severity and duration of illness in major depression. Psychol Med, 2014, 44(6): 1171-1182.
10. Peng Hongjun, Zheng Huirong, Ning Yuping, et al. Abnormalities of cortical-limbic-cerebellar white matter networks may contribute to treatment-resistant depression: a diffusion tensor imaging study. BMC Psychiatry, 2013, 13: 72.
11. Murrough J W, Collins K A, Fields J, et al. Regulation of neural responses to emotion perception by ketamine in individuals with treatment-resistant major depressive disorder. Transl Psychiatry, 2015, 5: e509.
12. Johnston B A, Tolomeo S, Gradin V A, et al. Failure of hippocampal deactivation during loss events in treatment-resistant depression. Brain, 2015, 138(Pt 9): 2766-2776.
13. Yamamura T, Okamoto Y, Okada G, et al. Association of thalamic hyperactivity with treatment-resistant depression and poor response in early treatment for major depression: a resting-state fMRI study using fractional amplitude of low-frequency fluctuations. Transl Psychiatry, 2016, 6: e754.
14. Guo W B, Liu F, Xue Z M, et al. Alterations of the amplitude of low-frequency fluctuations in treatment-resistant and treatment-response depression: a resting-state fMRI study. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 37(1): 153-160.
15. Guo W B, Liu F, Chen J D, et al. Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: a resting-state fMRI study. J Psychiatr Res, 2012, 46(10): 1366-1373.
16. Cheng W, Rolls E T, Qiu J, et al. Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain, 2016, 139(12): 3296-3309.
17. He Zongling, Cui Qian, Zheng Junjie, et al. Frequency-specific alterations in functional connectivity in treatment-resistant and -sensitive major depressive disorder. J Psychiatr Res, 2016, 82: 30-39.
18. Guo Wenbin, Liu Feng, Xue Zhimin, et al. Abnormal resting-state cerebellar-cerebral functional connectivity in treatment-resistant depression and treatment sensitive depression. Prog Neuropsychopharmacol Biol Psychiatry, 2013, 44: 51-57.
19. Lefebvre D, Langevin L M, Jaworska N A, et al. A pilot study of hippocampal N-acetyl-aspartate in youth with treatment resistant major depression. J Affect Disord, 2017, 207: 110-113.
20. Yang Xiaoru, Langevin L M, Jaworska N, et al. Proton spectroscopy study of the dorsolateral prefrontal cortex in youth with familial depression. Psychiatry Clin Neurosci, 2016, 70(7, SI): 269-277.
21. Li C T, Su T P, Wang S J, et al. Prefrontal glucose metabolism in medication-resistant major depression. Br J Psychiatry, 2015, 206(4): 316-323.
22. Peng Wei, Chen Ziqi, Yin Li, et al. Essential brain structural alterations in major depressive disorder: A voxel-wise meta-analysis on first episode, medication-naive patients. J Affect Disord, 2016, 199: 114-123.
23. Gong Qiyong, He Yong. Depression, neuroimaging and connectomics: a selective overview. Biol Psychiatry, 2015, 77(3): 223-235.
24. Zhang Huawei, Chen Ziqi, Jia Zhiyun, et al. Dysfunction of neural circuitry in depressive patients with suicidal behaviors: a review of structural and functional neuroimaging studies. Prog Neuropsychopharmacol Biol Psychiatry, 2014, 53: 61-66.
25. Jia Zhiyun, Wang Yuqing, Huang Xiaoqi, et al. Impaired frontothalamic circuitry in suicidal patients with depression revealed by diffusion tensor imaging at 3.0 T. J Psychiatry Neurosci, 2014, 39(3): 170-177.
26. Baeken C, Marinazzo D, Wu Guorong, et al. Accelerated HF-rTMS in treatment-resistant unipolar depression: Insights from subgenual anterior cingulate functional connectivity. World J Biol Psychiatry, 2014, 15(4): 286-297.
27. Yang Xiaoru, Kirton A, Wilkes T C, et al. Glutamate alterations associated with transcranial magnetic stimulation in youth depression a case series. J ECT, 2014, 30(3): 242-247.
28. 邓佳慧, 李素霞, 董问天, 等. 难治性抑郁症发病机制的研究进展. 中国神经精神疾病杂志, 2014, 40(2): 123-126.

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Current progress in neuroimaging research on treatment resistant depression

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