The effect of secondary Bjerknes force in sonoporation on cell by ultrasound-mediated microbubbles_Journal of Biomedical Engineering

Authors：

XU Liang ¹ , LIN Zhongshi ¹ , SHEN Yuanyuan ² ,  YU Hao ³

1. Shenzhen Institute for Drug Control, Shenzhen, Guangdong 518056, P.R.China;
2. School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, Guangdong 518060, P.R.China;
3. Department of Biomedical Engineering, Shenzhen Polytechnic, Shenzhen, Guangdong 518055, P.R.China;

Corresponding author：

YU Hao, Email: yuhao_zju@163.com

Keywords：

ultrasound-mediated microbubble; cell; secondary Bjerknes force; sonoporation

DOI：

10.7507/1001-5515.201801017

Video：

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In sonoporation, the cell membrane is broken-up temporarily by ultrasound mediated microbubbles, which is promoting drug or gene into the cell. In current literatures, there are numerous studies of single microbubble dynamics in sonoporation. However till now, little studies have been focused on the sonoporation incidence caused by more than one microbubble. In this article, the dynamic model of two adjacent microbubbles in stable cavitation has been introduced. By the model, the forces including secondary Bjerknes force on cell membrane given by microbubbles and their effects on sonoporation have been numerically studied. According to the experimental parameters, we numerically studied (1) effects of the ultrasound and microbubble parameters on the secondary Bjerknes forces; (2) the forces exerted on cell membrane by microbubble, including the secondary Bjerknes force; (3) the sonoporation possibility caused by those forces produced by microbubble. In this article, the ultrasound and microbubbles’ parameters range were found to produce sonoporation by two adjacent microbubbles. Furthermore, it is the first time to found that the microbubbles’ parameters are more important than ultrasound parameters on sonoporation.

Citation： XU Liang, LIN Zhongshi, SHEN Yuanyuan, YU Hao. The effect of secondary Bjerknes force in sonoporation on cell by ultrasound-mediated microbubbles. Journal of Biomedical Engineering, 2018, 35(6): 864-869. doi: 10.7507/1001-5515.201801017 Copy

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2.	Tsai K C, Fang S Y, Yang S J, et al. Time dependency of ultrasound-facilitated gene transfection. J Gene Med, 2009, 11(8): 729-736.
3.	Sirsi S R, Borden M A. Advances in ultrasound mediated gene therapy using microbubble contrast agents. Theranostics, 2012, 2(12): 1208-1222.
4.	Escoffre J M, Zeghimi A, Novell A, et al. In-vivo gene delivery by sonoporation: recent progress and prospects. Curr Gene Ther, 2013, 13(1): 2-14.
5.	Zhou Yufeng. Ultrasound-mediated drug/gene delivery in solid tumor treatment. J Healthc Eng, 2013, 4(2): 223-254.
6.	Lentacker I, De Cock I, Deckers R, et al. Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms. Adv Drug Deliv Rev, 2014, 72: 49-64.
7.	陈谦, 邹欣晔, 程建春. 超声波声孔效应中气泡动力学的研究. 物理学报, 2006, 55(12): 6476-6481.
8.	Yu Hao, Xu Liang, Chen Siping. A transfer efficiency model for ultrasound mediated drug/gene transferring into cells. Ultrason Sonochem, 2014, 21(1): 113-120.
9.	Lu Yuan, Katz J, Prosperetti A. Dynamics of cavitation clouds within a high-intensity focused ultrasonic beam. Phys Fluid, 2013, 25(7): 073301.
10.	Alibakhshi M A, Holt R G. Suppressing shape instabilities to discover the Bjerknes force instability (L). J Acoust Soc Am, 2011, 130(5): 3321-3324.
11.	Mettin R, Akhatov I, Parlitz U, et al. Bjerknes forces between small cavitation bubbles in a strong acoustic field. Phys Rev E, 1997, 56(3): 2924-2931.
12.	Doinikov A A. Translational motion of a spherical bubble in an acoustic standing wave of high intensity. Phys Fluids, 2002, 14(4): 1420-1425.
13.	Marmottant P, van der Meer S, Emmer M, et al. A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. J Acoust Soc Am, 2005, 118(6): 3499-3505.
14.	Morgan K E, Allen J S, Dayton P A, et al. Experimental and theoretical evaluation of microbubble behavior: Effect of transmitted phase and bubble size. IEEE Trans Ultrason Ferroelectr Freq Control, 2000, 47(6): 1494-1509.
15.	龙东平, 谭建平. 红细胞表面摩擦特性的AFM研究. 润滑与密封, 2009, 34(12): 10-14.
16.	马艳, 林书玉, 鲜晓军. 次Bjerknes力作用下气泡的体积振动和散射声场. 物理学报, 2016, 65(1): 014301.
17.	Yu Hao, Lin Zhongshi, Xu Liang, et al. Theoretical study of microbubble dynamics in sonoporation. Ultrasonics, 2015, 61: 136-144.

1. Wu Junru, Pepe J, Rincón M. Sonoporation, anti-cancer drug and antibody delivery using ultrasound. Ultrasonics, 2006, 44(Suppl 1): e21-e25.
2. Tsai K C, Fang S Y, Yang S J, et al. Time dependency of ultrasound-facilitated gene transfection. J Gene Med, 2009, 11(8): 729-736.
3. Sirsi S R, Borden M A. Advances in ultrasound mediated gene therapy using microbubble contrast agents. Theranostics, 2012, 2(12): 1208-1222.
4. Escoffre J M, Zeghimi A, Novell A, et al. In-vivo gene delivery by sonoporation: recent progress and prospects. Curr Gene Ther, 2013, 13(1): 2-14.
5. Zhou Yufeng. Ultrasound-mediated drug/gene delivery in solid tumor treatment. J Healthc Eng, 2013, 4(2): 223-254.
6. Lentacker I, De Cock I, Deckers R, et al. Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms. Adv Drug Deliv Rev, 2014, 72: 49-64.
7. 陈谦, 邹欣晔, 程建春. 超声波声孔效应中气泡动力学的研究. 物理学报, 2006, 55(12): 6476-6481.
8. Yu Hao, Xu Liang, Chen Siping. A transfer efficiency model for ultrasound mediated drug/gene transferring into cells. Ultrason Sonochem, 2014, 21(1): 113-120.
9. Lu Yuan, Katz J, Prosperetti A. Dynamics of cavitation clouds within a high-intensity focused ultrasonic beam. Phys Fluid, 2013, 25(7): 073301.
10. Alibakhshi M A, Holt R G. Suppressing shape instabilities to discover the Bjerknes force instability (L). J Acoust Soc Am, 2011, 130(5): 3321-3324.
11. Mettin R, Akhatov I, Parlitz U, et al. Bjerknes forces between small cavitation bubbles in a strong acoustic field. Phys Rev E, 1997, 56(3): 2924-2931.
12. Doinikov A A. Translational motion of a spherical bubble in an acoustic standing wave of high intensity. Phys Fluids, 2002, 14(4): 1420-1425.
13. Marmottant P, van der Meer S, Emmer M, et al. A model for large amplitude oscillations of coated bubbles accounting for buckling and rupture. J Acoust Soc Am, 2005, 118(6): 3499-3505.
14. Morgan K E, Allen J S, Dayton P A, et al. Experimental and theoretical evaluation of microbubble behavior: Effect of transmitted phase and bubble size. IEEE Trans Ultrason Ferroelectr Freq Control, 2000, 47(6): 1494-1509.
15. 龙东平, 谭建平. 红细胞表面摩擦特性的AFM研究. 润滑与密封, 2009, 34(12): 10-14.
16. 马艳, 林书玉, 鲜晓军. 次Bjerknes力作用下气泡的体积振动和散射声场. 物理学报, 2016, 65(1): 014301.
17. Yu Hao, Lin Zhongshi, Xu Liang, et al. Theoretical study of microbubble dynamics in sonoporation. Ultrasonics, 2015, 61: 136-144.

Journal of Biomedical Engineering

The effect of secondary Bjerknes force in sonoporation on cell by ultrasound-mediated microbubbles

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