Effects of parameters selection with transcranial direct current stimulation based on real head model_Journal of Biomedical Engineering

Authors：

WANG Hongli ^1,2 ,  YU Hongli ^1,2 , WANG Chao ^1,2 , XU Guizhi ^1,2 , GUO Lei ^1,2

1. State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin 300130, P.R.China;
2. Tianjin Key Laboratory of Bioelectromagnetic Technology and Intelligent Health, Hebei University of Technology, Tianjin 300130, P.R.China;

Corresponding author：

YU Hongli, Email: yhlzyn@hebut.edu.cn

Keywords：

transcranial direct current stimulation; current intensity; electrode shape and area; electrode spacing

DOI：

10.7507/1001-5515.202005050

Video：

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Transcranial direct current stimulation (tDCS) is a brain stimulation intervention technique, which has the problem of different criteria for the selection of stimulation parameters. In this study, a four-layer real head model was constructed. Based on this model, the changes of the electric field distribution in the brain with the current intensity, electrode shape, electrode area and electrode spacing were analyzed by using finite element simulation technology, and then the optimal scheme of electrical stimulation parameters was discussed. The results showed that the effective stimulation region decreased and the focusing ability increased with the increase of current intensity. The normal current density of the quadrilateral electrode was obviously larger than that of the circular electrode, which indicated that the quadrilateral electrode was more conducive to current stimulation of neurons. Moreover, the effective stimulation region of the quadrilateral electrode was more concentrated and the focusing ability was stronger. The focusing ability decreased with the increase of electrode area. Specifically, the focusing tended to increase first and then decrease with the increase of electrode spacing and the optimal electrode spacing was 64.0–67.2 mm. These results could provide some basis for the selection of electrical stimulation parameters.

Citation： WANG Hongli, YU Hongli, WANG Chao, XU Guizhi, GUO Lei. Effects of parameters selection with transcranial direct current stimulation based on real head model. Journal of Biomedical Engineering, 2021, 38(4): 638-646. doi: 10.7507/1001-5515.202005050 Copy

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2.	Soekadar S R, Witkowski M, Cossio E G, et al. Learned EEG-based brain self-regulation of motor-related oscillations during application of transcranial electric brain stimulation: feasibility and limitations. Front Behav Neurosci, 2014, 8: 93.
3.	Marquez J, Conley A, Karayanidis F, et al. Anodal direct current stimulation in the healthy aged: effects determined by the hemisphere stimulated. Restor Neurol Neurosci, 2015, 33(4): 509-519.
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5.	Nitsche M A, Cohen L G, Wassermann E M, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul, 2008, 1(3): 206-223.
6.	Madhavan S, Shah B. Enhancing motor skill learning with transcranial direct current stimulation - a concise review with applications to stroke. Front Psychiatry, 2012, 3: 66.
7.	Mayer J T, Chopard G, Nicolier M, et al. Can transcranial direct current stimulation (tDCS) improve impulsivity in healthy and psychiatric adult populations? a systematic review. Prog Neuro-Psychopharmacol Biol Psychiatry, 2020, 98: 109814.
8.	刘莹, 桂裕昌, 许建文, 等. 阳极经颅直流电刺激联合康复治疗对外伤性脊髓损伤运动功能障碍的康复疗效. 华西医学, 2019, 34(5): 52-57.
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12.	Talsma L J, Kroese H A, Slagter H A. Boosting cognition: effects of multiple-session transcranial direct current stimulation on working memory. J Cogn Neurosci, 2017, 29(4): 755-768.
13.	Westwood S J, Romani C. Null effects on working memory and verbal fluency tasks when applying anodal tDCS to the inferior frontal gyrus of healthy participants. Front Neurosci, 2018, 12: 166.
14.	Nikolin S, Lauf S, Loo C K, et al. Effects of high-definition transcranial direct current stimulation (HD-tDCS) of the intraparietal sulcus and dorsolateral prefrontal cortex on working memory and divided attention. Front Integr Neurosci, 2019, 12: 64.
15.	钟刚亮, 张广浩, 任艳萍, 等. 真实头模型中改良电休克与磁休克治疗的电场仿真分析. 生物医学工程学杂志, 2018, 35(4): 70-76.
16.	章健伟, 吴伟娟, 应小艳, 等. 基于分类体数据的五层有限元真实头模型建立. 生物医学工程学杂志, 2011, 28(3): 587-591.
17.	Datta A, Zhou X, Su Y, et al. Validation of finite element model of transcranial electrical stimulation using scalp potentials: implications for clinical dose. J Neural Eng, 2013, 10(3): 036018.
18.	Das S, Holland P, Frens M A, et al. Impact of transcranial direct current stimulation (tDCS) on neuronal functions. Front Neurosci, 2016, 10: 550.
19.	Sadleir R J, Vannorsdall T D, Schretlen D J, et al. Transcranial direct current stimulation (tDCS) in a realistic head model. Neuroimage, 2010, 51(4): 1310-1318.
20.	Turkeltaub P E, Benson J, Hamilton R H, et al. Left lateralizing transcranial direct current stimulation improves reading efficiency. Brain Stimul, 2012, 5(3): 201-207.
21.	柯丽, 高彦照, 杜强, 等. 四层复杂球颅脑模型的构建. 中国生物医学工程学报, 2016, 35(1): 55-62.
22.	Nitsche M A, Doemkes S, Karakose T, et al. Shaping the effects of transcranial direct current stimulation of the human motor cortex. J Neurophysiol, 2007, 97(4): 3109-3117.
23.	Faria P, Hallett M, Miranda P C. A finite element analysis of the effect of electrode area and inter-electrode distance on the spatial distribution of the current density in tDCS. J Neural Eng, 2011, 8(6): 066017.
24.	Bikson M, Datta A, Rahman A. Electrode montages for tDCS and weak transcranial electrical stimulation: role of “return” electrode’s position and size. Clin Neurophysiol, 2010, 121(12): 1976-1978.
25.	Rushton W A. The effect upon the threshold for nervous excitation of the length of nerve exposed, and the angle between current and nerve. J Physiol, 1927, 63(4): 357-377.
26.	Carbunaru R, Durand D M. Toroidal coil models for transcutaneous magnetic stimulation of nerves. IEEE Trans Biomed Eng, 2001, 48(4): 434-441.
27.	Bikson M, Grossman P, Thomas C, et al. Safety of transcranial direct current stimulation: evidence based update 2016. Brain Stimul, 2016, 9(5): 641-661.
28.	Kronberg G, Rahman A, Sharma M, et al. Direct current stimulation boosts hebbian plasticity in vitro. Brain Stimul, 2020, 13(2): 287-301.
29.	Nitsche M A, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol, 2000, 527(3): 633-639.

1. Nitsche M A, Paulus W. Sustained excitability elevations induced by transcranial dc motor cortex stimulation in humans. Neurology, 2001, 57(10): 1899-1901.
2. Soekadar S R, Witkowski M, Cossio E G, et al. Learned EEG-based brain self-regulation of motor-related oscillations during application of transcranial electric brain stimulation: feasibility and limitations. Front Behav Neurosci, 2014, 8: 93.
3. Marquez J, Conley A, Karayanidis F, et al. Anodal direct current stimulation in the healthy aged: effects determined by the hemisphere stimulated. Restor Neurol Neurosci, 2015, 33(4): 509-519.
4. Hummel F C, Cohen L G. Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke?. Lancet Neurol, 2006, 5(8): 708-712.
5. Nitsche M A, Cohen L G, Wassermann E M, et al. Transcranial direct current stimulation: state of the art 2008. Brain Stimul, 2008, 1(3): 206-223.
6. Madhavan S, Shah B. Enhancing motor skill learning with transcranial direct current stimulation - a concise review with applications to stroke. Front Psychiatry, 2012, 3: 66.
7. Mayer J T, Chopard G, Nicolier M, et al. Can transcranial direct current stimulation (tDCS) improve impulsivity in healthy and psychiatric adult populations? a systematic review. Prog Neuro-Psychopharmacol Biol Psychiatry, 2020, 98: 109814.
8. 刘莹, 桂裕昌, 许建文, 等. 阳极经颅直流电刺激联合康复治疗对外伤性脊髓损伤运动功能障碍的康复疗效. 华西医学, 2019, 34(5): 52-57.
9. Parkin B L, Bhandari M, Glen J C, et al. The physiological effects of transcranial electrical stimulation do not apply to parameters commonly used in studies of cognitive neuromodulation. Neuropsychologia, 2019, 128: 332-339.
10. Peterchev A V, Wagner T A, Miranda P C, et al. Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices. Brain Stimul, 2012, 5(4): 435-453.
11. Gozenman F, Berryhill M E. Working memory capacity differentially influences responses to tDCS and HD-tDCS in a retro-cue task. Neurosci Lett, 2016, 629: 105-109.
12. Talsma L J, Kroese H A, Slagter H A. Boosting cognition: effects of multiple-session transcranial direct current stimulation on working memory. J Cogn Neurosci, 2017, 29(4): 755-768.
13. Westwood S J, Romani C. Null effects on working memory and verbal fluency tasks when applying anodal tDCS to the inferior frontal gyrus of healthy participants. Front Neurosci, 2018, 12: 166.
14. Nikolin S, Lauf S, Loo C K, et al. Effects of high-definition transcranial direct current stimulation (HD-tDCS) of the intraparietal sulcus and dorsolateral prefrontal cortex on working memory and divided attention. Front Integr Neurosci, 2019, 12: 64.
15. 钟刚亮, 张广浩, 任艳萍, 等. 真实头模型中改良电休克与磁休克治疗的电场仿真分析. 生物医学工程学杂志, 2018, 35(4): 70-76.
16. 章健伟, 吴伟娟, 应小艳, 等. 基于分类体数据的五层有限元真实头模型建立. 生物医学工程学杂志, 2011, 28(3): 587-591.
17. Datta A, Zhou X, Su Y, et al. Validation of finite element model of transcranial electrical stimulation using scalp potentials: implications for clinical dose. J Neural Eng, 2013, 10(3): 036018.
18. Das S, Holland P, Frens M A, et al. Impact of transcranial direct current stimulation (tDCS) on neuronal functions. Front Neurosci, 2016, 10: 550.
19. Sadleir R J, Vannorsdall T D, Schretlen D J, et al. Transcranial direct current stimulation (tDCS) in a realistic head model. Neuroimage, 2010, 51(4): 1310-1318.
20. Turkeltaub P E, Benson J, Hamilton R H, et al. Left lateralizing transcranial direct current stimulation improves reading efficiency. Brain Stimul, 2012, 5(3): 201-207.
21. 柯丽, 高彦照, 杜强, 等. 四层复杂球颅脑模型的构建. 中国生物医学工程学报, 2016, 35(1): 55-62.
22. Nitsche M A, Doemkes S, Karakose T, et al. Shaping the effects of transcranial direct current stimulation of the human motor cortex. J Neurophysiol, 2007, 97(4): 3109-3117.
23. Faria P, Hallett M, Miranda P C. A finite element analysis of the effect of electrode area and inter-electrode distance on the spatial distribution of the current density in tDCS. J Neural Eng, 2011, 8(6): 066017.
24. Bikson M, Datta A, Rahman A. Electrode montages for tDCS and weak transcranial electrical stimulation: role of “return” electrode’s position and size. Clin Neurophysiol, 2010, 121(12): 1976-1978.
25. Rushton W A. The effect upon the threshold for nervous excitation of the length of nerve exposed, and the angle between current and nerve. J Physiol, 1927, 63(4): 357-377.
26. Carbunaru R, Durand D M. Toroidal coil models for transcutaneous magnetic stimulation of nerves. IEEE Trans Biomed Eng, 2001, 48(4): 434-441.
27. Bikson M, Grossman P, Thomas C, et al. Safety of transcranial direct current stimulation: evidence based update 2016. Brain Stimul, 2016, 9(5): 641-661.
28. Kronberg G, Rahman A, Sharma M, et al. Direct current stimulation boosts hebbian plasticity in vitro. Brain Stimul, 2020, 13(2): 287-301.
29. Nitsche M A, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol, 2000, 527(3): 633-639.

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Effects of parameters selection with transcranial direct current stimulation based on real head model

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