Study on deep brain magnetic stimulation method based on magnetic replicator_Journal of Biomedical Engineering

Authors：

WU Nianshuang ^1,2 , LIU Haijun ³ , WANG Jiahao ^1,2 , ZHANG Cheng ^1,2 , WU Changzhe ¹ , HUO Xiaolin ^1,2 ,  ZHANG Guanghao ^1,2

1. Beijing Key Laboratory of Bioelectromagnetism, Institute of Electrical Engineering, Chinese Academy of Sciences, Beijing 100190, P. R. China;
2. School of Electronics, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, P. R. China;
3. HUGER Medical Instrument Co. , Ltd, Shanghai 201619, P. R. China;

Corresponding author：

ZHANG Guanghao, Email: zhangguanghao@mail.iee.ac.cn

Keywords：

Transcranial magnetic stimulation; Transcranial electrical stimulation; Negative magnetic permeability; Focusing; Deep brain stimulation

DOI：

10.7507/1001-5515.202210013

Video：

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Abstract Full text Figures/Tables Video References Cited by

Existing neuroregulatory techniques can achieve precise stimulation of the whole brain or cortex, but high-focus deep brain stimulation has been a technical bottleneck in this field. In this paper, based on the theory of negative permeability emerged in recent years, a simulation model of magnetic replicator is established to study the distribution of the induced electric field in the deep brain and explore the possibility of deep focusing, which is compared with the traditional magnetic stimulation method. Simulation results show that a single magnetic replicator realized remote magnetic source. Under the condition of the same position and compared with the traditional method of stimulating, the former generated smaller induced electric field which sharply reduced with distance. By superposition of the magnetic field replicator, the induced electric field intensity could be increased and the focus could be improved, reducing the number of peripheral wires while guaranteeing good focus. The magnetic replicator model established in this paper provides a new idea for precise deep brain stimulation, which can be combined with neuroregulatory techniques in the future to lay a foundation for clinical application.

Citation： WU Nianshuang, LIU Haijun, WANG Jiahao, ZHANG Cheng, WU Changzhe, HUO Xiaolin, ZHANG Guanghao. Study on deep brain magnetic stimulation method based on magnetic replicator. Journal of Biomedical Engineering, 2023, 40(1): 1-7. doi: 10.7507/1001-5515.202210013 Copy

1.	Barker A T, Freeston I L, Jalinous R, et al. Non-invasive stimulation of motor pathways within the brain using time-varying magnetic-fields. Electroencephalography Clinical Neurophysiology, 1985, 61(3): S245-S246.
2.	Valiengo L, Pinto B S, Marinho K A P, et al. Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: study protocol for a randomized, double-blind, controlled trial. Frontiers in Human Neuroscience, 2022, 16: 941981.
3.	Stultz D J, Osburn S, Burns T, et al. Transcranial magnetic stimulation (TMS) safety with respect to seizures: a literature review. Neuropsychiatr Disease Treatment, 2020, 16: 2989-3000.
4.	Bruno V, Fossataro C, Garbarini F. Report of seizure induced by 10 Hz rTMS over M1. Brain Stimulation, 2018, 11(2): 454-455.
5.	Valero-Cabre A, Amengual J L, Stengel C, et al. Transcranial magnetic stimulation in basic and clinical neuroscience: a comprehensive review of fundamental principles and novel insights. Neuroscience and Biobehavioral Reviews, 2017, 83: 381-404.
6.	Taylor R, Galvez V, Loo C. Transcranial magnetic stimulation (TMS) safety: a practical guide for psychiatrists. Australasian Psychiatry, 2018, 26(2): 189-192.
7.	Koponen L M, Nieminen J O, Mutanen T P, et al. Coil optimisation for transcranial magnetic stimulation in realistic head geometry. Brain Stimulation, 2017, 10(4): 795-805.
8.	Rastogi P, Lee E G, Hadimani R L, et al. Transcranial magnetic stimulation-coil design with improved focality. AIP Advances, 2017, 7(5): 056705.
9.	Konakanchi D, de Jongh Curry A L, Waters R S, et al. Focality of the induced E-field is a contributing factor in the choice of TMS parameters: evidence from a 3D computational model of the human brain. Brain Sciences, 2020, 10(12): 1010.
10.	Ueno S, Tashiro T, Harada K. Localized stimulation of neural tissues in the brain by means of a paired configuration of time-varying magnetic-fields. Journal of Applied Physics, 1988, 64(10): 5862-5864.
11.	Harmelech T, Roth Y, Tendler A. Deep TMS H7 coil: features, applications & future. Expert Review of Medical Devices, 2021, 18(12): 1133-1144.
12.	Abellaneda-Pérez K, Vaqué-Alcázar L, Perellón-Alfonso R, et al. Differential tDCS and tACS effects on working memory-related neural activity and resting-state connectivity. Frontiers in Neuroscience, 2019, 13: 1440.
13.	Sudbrack-Oliveira P, Barbosa M Z, Thome-Souza S, et al. Transcranial direct current stimulation (tDCS) in the management of epilepsy: a systematic review. Seizure, 2021, 86: 85-95.
14.	Sreeraj V S, Suhas S, Parlikar R, et al. Effect of add-on transcranial alternating current stimulation (tACS) on persistent delusions in schizophrenia. Psychiatry Research, 2020, 290: 113106.
15.	Matsumoto H, Ugawa Y. Adverse events of tDCS and tACS: a review. Clinical Neurophysiology Practice, 2016, 2: 19-25.
16.	Benussi A, Cantoni V, Cotelli M S, et al. Exposure to gamma tACS in Alzheimer's disease: a randomized, double-blind, sham-controlled, crossover, pilot study. Brain Stimulation, 2021, 14(3): 531-540.
17.	Wang H, Wang K, Xue Q, et al. Transcranial alternating current stimulation for treating depression: a randomized controlled trial. Brain, 2022, 145(1): 83-91.
18.	Haller N, Senner F, Brunoni A R, et al. Gamma transcranial alternating current stimulation improves mood and cognition in patients with major depression. Journal of Psychiatric Research, 2020, 130: 31-34.
19.	Alexander M L, Alagapan S, Lugo C E, et al. Double-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (tACS) for the treatment of major depressive disorder (MDD). Translation Psychiatry, 2019, 9(1): 106.
20.	Riddle J, Rubinow D R, Frohlich F. A case study of weekly tACS for the treatment of major depressive disorder. Brain Stimulation, 2020, 13(3): 576-577.
21.	Breitling C, Zaehle T, Dannhauer M, et al. Comparison between conventional and HD-tDCS of the right inferior frontal gyrus in children and adolescents with ADHD. Clinical Neurophysiology, 2020, 131(5): 1146-1154.
22.	Grossman N, Bono D, Dedic N, et al. Noninvasive deep brain stimulation via temporally interfering electric fields. Cell, 2017, 169(6): 1029-1041.
23.	Voroslakos M, Takeuchi Y, Brinyiczki K, et al. Direct effects of transcranial electric stimulation on brain circuits in rats and humans. Nature Communications, 2018, 9(1): 483.
24.	Sorkhabi M M, Wendt K, Denison T. Temporally interfering TMS: focal and dynamic stimulation location. Annual International Conference of the IEEE Engineering in Medicine Biology Society, 2020, 2020: 3537-3543.
25.	Xin Z, Kuwahata A, Liu S, et al. Magnetically induced temporal interference for focal and deep-brain stimulation. Frontiers in Human Neuroscience, 2021, 15: 693207.
26.	Mach-Batlle R, Parra A, Prat-Camps J, et al. Negative permeability in magnetostatics and its experimental demonstration. Physical Review B, 2017, 96(9): 094422.
27.	Mach-Batlle R, Parra A, Laut S, et al. Magnetic illusion: Transforming a magnetic object into another object by negative permeability. Physical Review Applied, 2018, 9(3): 034007.
28.	Mach-Batlle R, Bason M G, Del-Valle N, et al. Tailoring magnetic fields in inaccessible regions. Physical Review Letters, 2020, 125(17): 177204.
29.	Gomez L J, Goetz S M, Peterchev A V. Design of transcranial magnetic stimulation coils with optimal trade-off between depth, focality, and energy. Journal of Neural Engineering, 2018, 15(4): 046033.

1. Barker A T, Freeston I L, Jalinous R, et al. Non-invasive stimulation of motor pathways within the brain using time-varying magnetic-fields. Electroencephalography Clinical Neurophysiology, 1985, 61(3): S245-S246.
2. Valiengo L, Pinto B S, Marinho K A P, et al. Treatment of depression in the elderly with repetitive transcranial magnetic stimulation using theta-burst stimulation: study protocol for a randomized, double-blind, controlled trial. Frontiers in Human Neuroscience, 2022, 16: 941981.
3. Stultz D J, Osburn S, Burns T, et al. Transcranial magnetic stimulation (TMS) safety with respect to seizures: a literature review. Neuropsychiatr Disease Treatment, 2020, 16: 2989-3000.
4. Bruno V, Fossataro C, Garbarini F. Report of seizure induced by 10 Hz rTMS over M1. Brain Stimulation, 2018, 11(2): 454-455.
5. Valero-Cabre A, Amengual J L, Stengel C, et al. Transcranial magnetic stimulation in basic and clinical neuroscience: a comprehensive review of fundamental principles and novel insights. Neuroscience and Biobehavioral Reviews, 2017, 83: 381-404.
6. Taylor R, Galvez V, Loo C. Transcranial magnetic stimulation (TMS) safety: a practical guide for psychiatrists. Australasian Psychiatry, 2018, 26(2): 189-192.
7. Koponen L M, Nieminen J O, Mutanen T P, et al. Coil optimisation for transcranial magnetic stimulation in realistic head geometry. Brain Stimulation, 2017, 10(4): 795-805.
8. Rastogi P, Lee E G, Hadimani R L, et al. Transcranial magnetic stimulation-coil design with improved focality. AIP Advances, 2017, 7(5): 056705.
9. Konakanchi D, de Jongh Curry A L, Waters R S, et al. Focality of the induced E-field is a contributing factor in the choice of TMS parameters: evidence from a 3D computational model of the human brain. Brain Sciences, 2020, 10(12): 1010.
10. Ueno S, Tashiro T, Harada K. Localized stimulation of neural tissues in the brain by means of a paired configuration of time-varying magnetic-fields. Journal of Applied Physics, 1988, 64(10): 5862-5864.
11. Harmelech T, Roth Y, Tendler A. Deep TMS H7 coil: features, applications & future. Expert Review of Medical Devices, 2021, 18(12): 1133-1144.
12. Abellaneda-Pérez K, Vaqué-Alcázar L, Perellón-Alfonso R, et al. Differential tDCS and tACS effects on working memory-related neural activity and resting-state connectivity. Frontiers in Neuroscience, 2019, 13: 1440.
13. Sudbrack-Oliveira P, Barbosa M Z, Thome-Souza S, et al. Transcranial direct current stimulation (tDCS) in the management of epilepsy: a systematic review. Seizure, 2021, 86: 85-95.
14. Sreeraj V S, Suhas S, Parlikar R, et al. Effect of add-on transcranial alternating current stimulation (tACS) on persistent delusions in schizophrenia. Psychiatry Research, 2020, 290: 113106.
15. Matsumoto H, Ugawa Y. Adverse events of tDCS and tACS: a review. Clinical Neurophysiology Practice, 2016, 2: 19-25.
16. Benussi A, Cantoni V, Cotelli M S, et al. Exposure to gamma tACS in Alzheimer's disease: a randomized, double-blind, sham-controlled, crossover, pilot study. Brain Stimulation, 2021, 14(3): 531-540.
17. Wang H, Wang K, Xue Q, et al. Transcranial alternating current stimulation for treating depression: a randomized controlled trial. Brain, 2022, 145(1): 83-91.
18. Haller N, Senner F, Brunoni A R, et al. Gamma transcranial alternating current stimulation improves mood and cognition in patients with major depression. Journal of Psychiatric Research, 2020, 130: 31-34.
19. Alexander M L, Alagapan S, Lugo C E, et al. Double-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (tACS) for the treatment of major depressive disorder (MDD). Translation Psychiatry, 2019, 9(1): 106.
20. Riddle J, Rubinow D R, Frohlich F. A case study of weekly tACS for the treatment of major depressive disorder. Brain Stimulation, 2020, 13(3): 576-577.
21. Breitling C, Zaehle T, Dannhauer M, et al. Comparison between conventional and HD-tDCS of the right inferior frontal gyrus in children and adolescents with ADHD. Clinical Neurophysiology, 2020, 131(5): 1146-1154.
22. Grossman N, Bono D, Dedic N, et al. Noninvasive deep brain stimulation via temporally interfering electric fields. Cell, 2017, 169(6): 1029-1041.
23. Voroslakos M, Takeuchi Y, Brinyiczki K, et al. Direct effects of transcranial electric stimulation on brain circuits in rats and humans. Nature Communications, 2018, 9(1): 483.
24. Sorkhabi M M, Wendt K, Denison T. Temporally interfering TMS: focal and dynamic stimulation location. Annual International Conference of the IEEE Engineering in Medicine Biology Society, 2020, 2020: 3537-3543.
25. Xin Z, Kuwahata A, Liu S, et al. Magnetically induced temporal interference for focal and deep-brain stimulation. Frontiers in Human Neuroscience, 2021, 15: 693207.
26. Mach-Batlle R, Parra A, Prat-Camps J, et al. Negative permeability in magnetostatics and its experimental demonstration. Physical Review B, 2017, 96(9): 094422.
27. Mach-Batlle R, Parra A, Laut S, et al. Magnetic illusion: Transforming a magnetic object into another object by negative permeability. Physical Review Applied, 2018, 9(3): 034007.
28. Mach-Batlle R, Bason M G, Del-Valle N, et al. Tailoring magnetic fields in inaccessible regions. Physical Review Letters, 2020, 125(17): 177204.
29. Gomez L J, Goetz S M, Peterchev A V. Design of transcranial magnetic stimulation coils with optimal trade-off between depth, focality, and energy. Journal of Neural Engineering, 2018, 15(4): 046033.

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