Therapeutic Results of Glucosamine Hydrochloride Capsules in Combination with Sodium Hyaluronate in the Treatment of Hip Osteoarthritis_West China Medical Journal

Authors：

WEN Chuanbing , DAI Yuee , LIN Tao , XU Yongjian ,  LAN Zhixun.

Department of Anesthesiology, Sichuan Academy of Medical Sciences & Sichuan Provincial People´s Hospital, Chengdu, Sichuan 610072, P. R. China;

Corresponding author：

LAN Zhixun., Email: sunwenshi2006@sohu.com

Keywords：

透明质酸钠; 盐酸氨基葡萄糖; 骨关节炎，髋

DOI：

10.7507/1002-0179.20130583

Video：

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目的　探讨盐酸氨基葡萄糖胶囊联合透明质酸钠注射液治疗髋骨关节炎的临床疗效。方法　纳入疼痛门诊2010年7月－2011年7月收治的髋骨关节炎患者60例，随机分为透明质酸钠关节腔内注射联合口服盐酸氨基葡萄糖胶囊组（A组）和单独透明质酸钠关节腔内注射组（B组），每组30例。透明质酸钠关节腔内注射均为2.5 mL/次，每周1次，连续5周为1疗程。盐酸氨基葡萄糖胶囊口服，0.75 g/次，2次/d，6周为1个疗程。评估两组患者治疗后6周后髋关节疼痛视觉模拟评分（VAS评分）及Lequesne指数评定髋关节休息痛、运动痛、局部压痛、关节活动度、晨僵及行走能力，并观察两组不良反应发生情况。结果　治疗6周后A组Lequesne功能指数及VAS评分较B组显著降低（P＜0.05），两组不良反应比较差异无统计学意义（P＞0.05）。结论　治疗髋骨关节炎患者时，联合应用透明质酸钠及盐酸氨基葡萄糖胶囊疗效优于单独应用透明质酸钠者，且并未增加不良反应的发生。

Citation： WEN Chuanbing,DAI Yuee,LIN Tao,XU Yongjian,LAN Zhixun.. Therapeutic Results of Glucosamine Hydrochloride Capsules in Combination with Sodium Hyaluronate in the Treatment of Hip Osteoarthritis. West China Medical Journal, 2013, 28(12): 1843-1845. doi: 10.7507/1002-0179.20130583 Copy

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8.	刘汉华, 蒋毅, 孙跃玲, 等. 玻璃酸钠联合盐酸氨基葡萄糖对膝骨关节炎患者血清MMP-9、TNF-α的影响[J]. 内科急危重症杂志, 2011, 17(1): 26-27.
9.	Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis[J]. Arzneimittelforschung, 1998, 48(5): 469-474.
10.	Tanaka H, Ueta Y, Yamashita U, et al. Biphasic changes in behaveiora, l indocrine, and sympathyetic systemes in adjuvant arthritis in lewis rats[J]. Bra in Res Bul, 1996, 39(1): 33-37.
11.	David E, Christopher J, Mark B, et al. Efficacy of intraarticular hyaluronic acid injections in knee osteoarthritis[J]. Clin Orthop Relat Res, 2001, 390(9): 173-181.
12.	Lomander LS, Dalen N, Englund G, et al. Intraarticular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled multicenter trial[J]. Ann Rheum Dis, 1996, 55(7): 424-431.
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1. 　孙瑛. 实用关节炎诊断治疗学[M]. 北京: 北京大学出版社, 2002: 319-333.
2. 　张里援, 冮湘保. 透明质酸钠关节内注射配合口服盐酸氨基葡萄糖胶囊治疗膝关节骨性关节炎的疗效分析[J]. 中国骨与关节外科, 2009, 2(6): 478-480.
3. 　中华医学会风湿病学分会. 骨关节炎诊断及治疗指南[J]. 中华风湿病学杂志, 2010, 14(6): 416-419.
4. 　Lequesne MG, Samson M. Indices of severity in osteoarthritis for weight bearing joints[J]. J Rheumatol Suppl, 1991, 27(27): 16-18.
5. 　Leslie M. Knee osteoarthritis management therapiea[J]. Pain Manag Nurs, 2000, 1(2): 51-57.
6. 　Fine PG. Treatment guidelines for the pharmacological management of pain in older persons[J]. Pain Med, 2012, 13 (Suppl 2): S57-S66.
7. 　Petrella LJ, Prospective PA. Randomizd, double-blind, placebo controlled study to evaluate the efficacy of intra-articular hyaluronic acid for asteoarthritis of the knee[J]. J Rheumatol, 2006, 33(5): 951-956.
8. 　刘汉华, 蒋毅, 孙跃玲, 等. 玻璃酸钠联合盐酸氨基葡萄糖对膝骨关节炎患者血清MMP-9、TNF-α的影响[J]. 内科急危重症杂志, 2011, 17(1): 26-27.
9. 　Qiu GX, Gao SN, Giacovelli G, et al. Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis[J]. Arzneimittelforschung, 1998, 48(5): 469-474.
10. 　Tanaka H, Ueta Y, Yamashita U, et al. Biphasic changes in behaveiora, l indocrine, and sympathyetic systemes in adjuvant arthritis in lewis rats[J]. Bra in Res Bul, 1996, 39(1): 33-37.
11. 　David E, Christopher J, Mark B, et al. Efficacy of intraarticular hyaluronic acid injections in knee osteoarthritis[J]. Clin Orthop Relat Res, 2001, 390(9): 173-181.
12. 　Lomander LS, Dalen N, Englund G, et al. Intraarticular hyaluronan injections in the treatment of osteoarthritis of the knee: a randomized, double blind, placebo controlled multicenter trial[J]. Ann Rheum Dis, 1996, 55(7): 424-431.
13. 　Da-Camara CC, Dowless GV. Glueesamine sulfate for ostonarthritis[J]. Ann Pharmacother, 1998, 32(5): 580.

West China Medical Journal

Therapeutic Results of Glucosamine Hydrochloride Capsules in Combination with Sodium Hyaluronate in the Treatment of Hip Osteoarthritis

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