Clinical Effect of Irbesartan on Patients with Senile Hypertension Complicated with Paroxysmal Atrial Fibrillation_West China Medical Journal

Authors：

 LIUJie

People's Hospital of Dujiangyan, Dujiangyan, Sichuan 611830, P. R. China;

Corresponding author：

Keywords：

Irbesartan; Senile hypertension; Atrial fibrillation

DOI：

10.7507/1002-0179.20140002

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Objective To explore the effect of irbesartan on patients with senile hypertension complicated with paroxysmal atrial fibrillation. Methods A total of 126 inpatients and outpatients over 60 years of age with senile hypertension complicated with paroxysmal atrial fibrillation treated in our hospital from July 2010 to August 2012 were randomized into the study group (n=63, treated with irbesartan) and the control group (n=63, treated with amlodipine besylate). Diuretics was added according to blood pressure of the patients. All the patients were followed up for 12 months. Blood pressure control situation, atrial fibrillation recurrence frequency and duration time, alteration of left atrial inner diameter were compared between the two groups. Results The level of blood pressure in both groups after treatment was significantly decreased compared with baseline, and there was no statistically significant difference in the decrease of blood pressure after treatment between the two groups (P>0.05). Atrial fibrillation recurrence frequency in the study group was (5.28±1.14) times, which was significantly lower than that in the control group[(9.24±1.34) times] (P<0.01). The paroxysmal atrial fibrillation duration time in the study group was (14.3±4.8) hours, which was significantly lower than that in the control group[(21.3±4.9) hours] (P<0.01). After treatment, the left atrial inner diameter in the study group was significantly diminished compared with that before treatment (P<0.01). Conclusion For patients with senile hypertension complicated with paroxysmal atrial fibrillation, irbesartan is effective to control blood pressure, decrease atrial fibrillation recurrence frequency and duration, and inhibit left atrioventricular remodeling.

Citation： LIUJie. Clinical Effect of Irbesartan on Patients with Senile Hypertension Complicated with Paroxysmal Atrial Fibrillation. West China Medical Journal, 2014, 29(1): 5-7. doi: 10.7507/1002-0179.20140002 Copy

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1. 胡大一, 孙艺红. 心房颤动的流行病学和治疗现状[J]. 中国全科医师杂志, 2006, 5(1):5-7.
2. 魏子秀,杨雪珍, 丛培玲, 等. 厄贝沙坦联合阿托伐他汀对急性心肌梗塞合并阵发性心房颤动患者复发的影响[J]. 中华老年心脑血管病杂志, 2011, 13(7):604-607.
3. 杨进刚. 心房颤动的诊断与药物治疗(中国专家共识)[J]. 心脑血管病防治, 2008, 8(4):215-221.
4. 刘力生. 2010年中国高血压防治指南[J]. 中华高血压杂志, 2011, 8(8):701-742.
5. 赵秀丽, 陈捷, 崔艳丽, 等. 中国14省市高血压现状的流行病学研究[J]. 中华医学杂志, 2006, 86(16):1148-1152.
6. 马宇虹, 李广平, 刘彤, 等. RAAS激活与急性心肌梗塞早期新发心房颤动的关系[J]. 山东医药, 2010, 50(4):6-28.
7. 周力, 王翠英, 陈晖, 等. 血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂在心房颤动一级预防中的可能作用[J]. 中华老年心脑血管病杂志, 2010, 12(12):1149-1150.
8. 薛玉梅, 吴书林, 邓春玉, 等. 缬沙坦对血管紧张素Ⅱ引起人心房肌细胞离子电流改变的调节作用[J]. 临床心血管杂志, 2005, 21(8):493-494.
9. 汤东澄. 厄贝沙坦与苯磺酸左旋氨氯地平治疗原发性高血压的疗效观察[J]. 中国药房, 2010, 21(40):397-398.
10. 赵颖, 胡大一, 杨新春, 等. 肽类血管紧张素Ⅱ受体拮抗剂对心肌细胞离子通道的影响[J]. 中华心血管病杂志, 2000, 28(1):58-60.
11. 周晓芳, 蔡力, 周鲁, 等. 氯沙坦对高血压患者生存质量影响的研究[J]. 西部医学, 2003, 14(1):23-25.
12. 裘晟, 陈肖君, 金庆吉, 等. 厄贝沙坦预防阵发性心房颤动复发作用的观察[J]. 心电学杂志, 2005, 24(2):74-75.
13. 邓仁生. 心房颤动复律后联用缬沙坦与胺碘酮的疗效[J]. 岭南心血管病杂志, 2006, 12(3):188-189.

West China Medical Journal

Clinical Effect of Irbesartan on Patients with Senile Hypertension Complicated with Paroxysmal Atrial Fibrillation

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