Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4<sup>+</sup> T Lymphocyte Number_West China Medical Journal

Authors：

 CAOFen ¹ , YEQing ²

1. Department of Ultrasound, Infectious Diseases Hospital of Chengdu, Chengdu, Sichuan 610061, P. R. China;
2. Department of Tranditional Chinese Medicine, Infectious Diseases Hospital of Chengdu, Chengdu, Sichuan 610061, P. R. China;

Corresponding author：

Keywords：

HIV; AIDS; Chronic hepatitis; Ultrasonic inspection; Pathological changes of the liver

DOI：

10.7507/1002-0179.20140022

Video：

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Objective To investigate the ultrasonic changes of liver during various immune periods with different number of CD4⁺ T lymphocytes in HIV/AIDS patients with chronic viral hepatitis. Methods The clinical data of 100 patients with chronic viral hepatitis diagnosed between January 2010 and December 2012 were selected. Among them, 50 simple chronic viral hepatitis patients were designated as the control group, and the other 50 HIV/AIDS patients with chronic viral hepatitis were regarded as the experimental group. Ultrasonographic observation was applied on patients of the experimental group according to different immune period based on the number of CD4⁺ T lymphocytes. Indexes observed included liver size, the edge of liver, capsule of liver and hepatic parenchymal echo. The cross-check analysis was employed between observed results and clinical laboratory results. Results Abnormal changes of the experimental group were shown on the ultrasound observation of liver in different CD4⁺ T lymphocyte count immune periods, including enlargement of the liver, slightly blunt liver margin, slightly thick capsule, dense and uniform, slightly rough and not so uniform, or rough and not uniform hepatic parenchymal echo. There was no significant difference in ultrasonic changes of liver between the two groups when the CD4⁺ T cell number was over 300/mm³. However, the difference was significant when the CD4⁺ T cell number was below 100/mm³. Conclusion Liver abnormalities become more obvious as CD4⁺ T cell count decreases in HIV/AIDS patients with chronic viral hepatitis. Comprehensive considerations of various liver ultrasound indicators are helpful in clinical evaluation of HIV/AIDS patients with chronic viral hepatitis.

Citation： CAOFen, YEQing. Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4⁺ T Lymphocyte Number. West China Medical Journal, 2014, 29(1): 80-82. doi: 10.7507/1002-0179.20140022 Copy

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1. 曹韵贞.艾滋病临床诊断、治疗及护理[M]. 北京:人民卫生出版社, 2002:148-149.
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3. 郭万学.超声医学[M]. 6版. 北京:人民卫生出版社, 2012:795-796.
4. den Brinker M, Wit FW, Wertheim-van Dillen PM, et al. Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection[J]. AIDS, 2000, 14(18):2895-2902.
5. 福军亮, 王福生. HIV和丙型肝炎病毒合并感染的临床特点和研究进展[J]. 中国艾滋病性病, 2005, 11(2):153-155.
6. 张新力, 陈重, 苏颖, 等. 慢性乙型及丙型病毒性肝炎的超声表现与病理对照分析[J]. 中华实验和临床病毒性杂志, 2003, 17(4):337-338.
7. 孟繁坤, 徐策, 张海英, 等. 对慢性病毒性肝炎超声诊断指标的再探讨[J]. 中国超声诊断杂志, 2002, 3(8):592-594.
8. 郑颖, 孟凡坤, 张海美, 等. 艾滋病腹部的声像图改变[J]. 中国超声诊断杂志, 2004, 5(5):358-360.
9. 莫让辉, 李论, 陆鹏.艾滋病合并乙、丙型肝炎96例分析[J]. 中国热带医学杂志, 2008, 8(10):1746-1748.

West China Medical Journal

Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4⁺ T Lymphocyte Number

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West China Medical Journal

Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4+ T Lymphocyte Number

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Study on the Correlation between Ultrasonographic Features of HIV/AIDS in Patients with Chronic Viral Hepatitis and CD4⁺ T Lymphocyte Number