Clinical Characteristics of Acute Kidney Injury in Hospitalized Patients with Chronic Obstructive Pulmonary Disease_West China Medical Journal

Authors：

 LIUAn-li ¹ , LIUYing ¹ , LIZhi-lian ² , CHENZi-xing ³ , YEGuang-lin ³ , TAOYi-ming ² , CHENYuan-han ² ,  LIANGXin-ling ²

1. Department of Respiratory Medicine, the First People's Hospital of Longquanyi District of Chengdu City, Chengdu, Sichuan 610100, P. R. China;
2. Department of Nephrology, People's Hospital, Guangzhou, Guangdong 510080, P. R. China;
3. Department of Respiratory Medicine, People's Hospital, Guangzhou, Guangdong 510080, P. R. China;

Corresponding author：

LIANGXin-ling, Email: xinlingliang@yahoo.com

Keywords：

Acute kidney disease; Chronic obstructive pulmonary disease; Adverse prognosis; Risk factor

DOI：

10.7507/1002-0179.20140073

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Objective To investigate the role on adverse prognosis and risk factors of acute kidney injury (AKI) in hospitalized patients with chronic obstructive pulmonary disease (COPD). Methods Clinical data from hospitalized patients with COPD between January 2009 and June 2012 were studied retrospectively.AKI was diagnosed and classified by AKIN criterion. Results Three hundred and sixty-nine patients were enrolled,among whom 69(18.6%) were complicated with AKI.The patients with AKI were older,and had higher levels of hemoglobin,hematocrit value and sodium concentration,and higher rates of comorbidities of diabetes mellitus,proteinuria and shock,compared with the controls.Those with AKI had a 24.1% increased risk for ventilator,121.5% for intensive care,and 89.8% for death.And a higher AKI grade was related to a worse prognosis.The increased risk of AKI was 142.1% for every 5-year increase of age,155.7% for every 0.1 increase of hematocrit value,70.5% for every 0.1 increase of sodium concentration,and 49.1%,89.2%,148.2% and 685.7% for being complicated with proteinuria,coronary artery disease,diabetes mellitus and shock. Conclusion AKI is associated with adverse prognosis in hospitalized patients with COPD.Age,proteinuria,increased levels of hematocrit value and sodium concentration,and comorbidities of coronary artery disease,diabetes mellitus and shock are independent risk factors for AKI

Citation： LIUAn-li, LIUYing, LIZhi-lian, CHENZi-xing, YEGuang-lin, TAOYi-ming, CHENYuan-han, LIANGXin-ling. Clinical Characteristics of Acute Kidney Injury in Hospitalized Patients with Chronic Obstructive Pulmonary Disease. West China Medical Journal, 2014, 29(2): 236-238. doi: 10.7507/1002-0179.20140073 Copy

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1. 温静,程庆砾.老年急性肾损伤的研究进展[J].中华临床医师杂志,2011,5(23):7064-7066.
2. Bellomo R,Ronco C,Kellum JA,et al.Acute renal failure-definition,outcome measures,animal models,fluid therapy and information technology needs:the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group[J].Crit Care,2004,8(4):R204-212.
3. Chertow GM,Burdick E,Honour M,et al.Acute kidney injury,mortality,length of stay,and costs in hospitalized patients[J].J Am Soc Nephrol,2005,16(11):3365-3370.
4. 蒋芬,陈源汉,梁馨苓,等.急性肾损伤RIFLE与AKIN标准在重症监护病房患者中的应用比较[J].中国危重病急救医学,2011,23(12):741-744.
5. 朱再志,许志忠,戚刚.慢性阻塞性肺病并发急性肾损伤的临床分析[J].华西医学,2010,25(8):1539-1540.
6. Ma YC,Zuo L,Chen JH,et al.Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease[J].J Am Soc Nephrol,2006,17(10):2937-2944.
7. Mehta RL,Kellum JA,Shah SV,et al.Acute Kidney Injury Network:report of an initiative to improve outcomes in acute kidney injury[J].Crit Care,2007,11(2):R31.
8. 中华医学会心血管病学分会.慢性心力衰竭诊断治疗指南[J].中华心血管病杂志,2007,35(12):1076-1095.
9. Kortgen A,Niederprum P,Bauer M.Implementation of an evidence-based "standard operating procedure" and outcome in septic shock[J].Crit Care Med,2006,34(4):943-949.
10. Grams M,Coresh J.Proteinuria and risk of acute kidney injury[J].Lancet,2010,376(9758):2046-2048.
11. 邢学忠,王海军,黄初林,等.非心脏外科术后危重患者急性肾损伤危险模型的建立和验证[J].中华临床医师杂志,2013,7(1):151-155.
12. Weber-Mzell D,Kotanko P,Schumacher M,et al.Coronary anatomy predicts presence or absence of renal artery stenosis.A prospective study in patients undergoing cardiac catheterization for suspected coronary artery disease[J].Eur Heart J,2002,23(21):1684-1691.

West China Medical Journal

Clinical Characteristics of Acute Kidney Injury in Hospitalized Patients with Chronic Obstructive Pulmonary Disease

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