Clinical Investigation of Associations between Early Lymphatic Metastasis of Gastric Cancer and Pathological Features_West China Medical Journal

Authors：

 JINXin ¹ , LILi ² , FENGLi ³ , LIFu-guang ¹ ,  WANGNing ¹

1. Department of General Surgery, Ankang Central Hospital, Ankang, Shaanxi 725000, P. R. China;
2. Department of General Surgery, Hospital of Shaanxi Normal University, Xi'an, Shaanxi 710062, P. R. China;
3. Department of Anorectum, Ankang Central Hospital, Ankang, Shaanxi 725000, P. R. China;

Corresponding author：

WANGNing, Email: scyclb@126.com

Keywords：

Stomach neoplasms; Early; Clinical pathology; Lymphatic metastasis

DOI：

10.7507/1002-0179.20140078

Video：

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Objective To investigate the rule of lymph node metastasis in early gastric cancer (EGC) so as to provide a reasonable treatment. Methods We retrospectively analyzed the clinical data of 118 EGC patients who had been treated from January 2006 to December 2012,and a total of 8 potential factors associated with occurrence of EGC were evaluated by univariate analysis and multivariate logistic regression analysis. Results The univariate analysis showed that ulcer,tumor size,depth of invasion and lymphatic involvement were correlated with lymph node metastasis (P<0.05).Multivariate logistic regression analysis showed that presence of an ulcer (OR=2.872),tumor of 3.0 cm or larger than that (OR=2.351),tumor invasion into the submucous layer (OR=3.461) and invasion into the lymphatic tubes (OR=1.784) were found to be independent risk factors. Conclusion Lymph node metastasis of EGC is correlated with many factors,so EGC treatment choice should be made reasonably based on strict screening to exclude various risk factors before taking surgery.

Citation： JINXin, LILi, FENGLi, LIFu-guang, WANGNing. Clinical Investigation of Associations between Early Lymphatic Metastasis of Gastric Cancer and Pathological Features. West China Medical Journal, 2014, 29(2): 252-255. doi: 10.7507/1002-0179.20140078 Copy

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1. Lai JF,Kim S,Kim K,et al.Prediction of recurrence of early gastric cancer after curative resection[J].Ann Surg Oncol,2009,16(7):1896-1902.
2. Maehara Y,Oshiro T,Endo K,et al.Clinical significance of occult micrometastasis lymph nodes from patients with early gastric cancer who died of recurrence[J].Surgery,1996,119(4):397-402.
3. Kunisaki C,Makino H,Akiyama H,et al.Clinical significance of the metastatic lymph-node ratio in early gastric cancer[J].J Gastrointest Surg,2008,12(3):542-549.
4. Lim MS,Lee HW,Im H,et al.Predictable factors for lymph node metastasis in early gastric cancer-analysis of single institutional experience[J].J Gastrointest Surg,2011,15(10):1783-1788.
5. Kim KJ,Park SJ,Moon W,et al.Analysis of factors related to lymph node metastasis in undifferentiated early gastric cancer[J].Turk J Gastroenterol,2011,22(2):139-144.
6. Abe N,Watanabe T,Sugiyama M,et al.Endoscopic treatment or surgery for undifferentiated early gastric cancer [J].Am J Surg,2004,188(2):181-184.
7. Okabayashi T,Kobayashi M,Nishimori I,et al.Clinicopathological features and medical management of early gastric cancer[J].Am J Surg,2008,195(2):229-232.
8. 王力,梁寒,王晓娜,等.早期胃癌淋巴结转移规律及影响因素[J].中华胃肠外科杂志,2013,16(2):147-150.
9. Lee JH,Choi MG,Min BH,et al.Predictive factors for lymph node metastasis in patients with poorly differentiated early gastric cancer[J].Br J Surg,2012,99(12):1688-1692.
10. Wang YX,Shao QS,Yang Q,et al.Clinicopathological characteristics and prognosis of early gastric cancer after gastrectomy[J].Chin Med J (Engl),2012,125(5):770-774.
11. 郑瑞,聂明明,张新,等.早期胃癌淋巴结转移与临床病理因素关系的临床研究[J].中华普外科手术学杂志,2012,6(2):8.
12. 武治铭,武爱文,李子禹,等.157例早期胃癌淋巴结转移特点及预后分析[J].中华胃肠外科杂志,2009,12(4):350-353.

West China Medical Journal

Clinical Investigation of Associations between Early Lymphatic Metastasis of Gastric Cancer and Pathological Features

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