Study on Effects of Different Penetration Enhancers on the Transdemal Penetration of Miao Medicine Named Diploclisia Affinis_West China Medical Journal

Authors：

 XUDing-ping

Department of Pharmacy, The Central Hospital of Enshi Autonomous Prefecture, Enshi, Hubei 445000, P. R. China;

Corresponding author：

Keywords：

Diploclisia affinis; Sinomenines; Penetration enhancers; Percutaneous absorption; High performance liquid chromatography

DOI：

10.7507/1002-0179.20140401

Video：

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Objective To study the effects of different penetration enhancers on the transdermal penetration of Miao medicine named Diploclisia affinis. Methods Improved Franz diffusion cell was adopted as the apparatus for in vitro mouse' skin permeation. The kinetic parameters of percutaneous absorption, such as penetration rate, enhancing rate (ER), and lag time (T_lag) were determined by high performance liquid chromatography. Azone, oleic acid (OA) and borneol were investigated for percutaneous absorption effects. Results The penetration rates of the medicine with 3% azone, OA and borneol added were respectively (214.1872±13.5690), (227.5544±9.8490), and (168.1187±21.5640) μg/(cm²·h), and the ER was 1.61, 1.71, and 1.26 compared with the penetration rate of that with nothing added. The T_lag was 2.1081, 1.8256, and 2.9655 hours. Conclusion All the penetration enhancers can increase significantly the absorption of Miao medicine named Diploclisia affinis, especially 3% OA is the best, but 3% borneol may make the T_lag longer.

Citation： XUDing-ping. Study on Effects of Different Penetration Enhancers on the Transdemal Penetration of Miao Medicine Named Diploclisia Affinis. West China Medical Journal, 2014, 29(7): 1316-1318. doi: 10.7507/1002-0179.20140401 Copy

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1. 方志先, 廖朝林. 湖北恩施药用植物志-上册[M]. 武汉:湖北科学技术出版社, 2006:459.
2. 中国科学院华南植物研究所. 广东植物志(第一卷)[M]. 广州:广东科技出版社, 1987:36.
3. 赵国平, 戴慎, 陈仁寿, 等. 中药大辞典[M]. 2版. 上海:上海科学技术出版社, 2006:516.
4. 徐定平. 苗药秤钩风中青藤碱的提取工艺研究[J]. 中国医药指南, 2013, 11(8):30-31.
5. 国家药典委员会. 中华人民共和国药典[M]. 北京:化学工业出版社, 2009:155-158.
6. 雷海民, 朱蓉, 魏璐雪. 异叶败酱化学成分的研究[J]. 中国药学杂志, 1997, 32(5):2712-2731.
7. 何嘉仑, 唐洪梅, 涂星, 等. 吴茱萸提取物的透皮吸收促进剂的筛选[J]. 中成药, 2013, 35(6):1184-1187.
8. 卢映, 涂星, 吴俊洪, 等. 不同基质和促渗剂对川芎嗪凝胶经皮吸收的影响[J]. 中药新药与临床药理, 2013, 24(2):166-169.
9. 周莉玲, 李锐, 周华, 等. 青藤碱制剂药动学相关性研究[J]. 中成药, 1996, 18(9):1.
10. Naik A, Pechtold L, Potts RO. Mechanism of oleic acid-induced skin penetration enhancement in vivo in humans[J]. J Controlled Release, 1995, 37(3):229.
11. Mangusson BM, Runn P, Karlsson K. Terpenes and ethanol enhance the transdermal permeation of the tripeptide[J]. Int J Pharm, 1997, 157(1):1113.
12. Ferrante M, Andreeta A, Landoni MF. Effect of different penetration enhancers on diclofenac permeation across horse skin[J]. Vet J, 2010, 186(3):312-315.
13. 李莉, 韩国柱. 中草药挥发油类透皮吸收促进作用研究进展[J]. 中国新药杂志, 2008, 17(11):914-918, 946.
14. 李熙, 刘玉亭, 吴淑梅, 等. 青藤碱微乳体外透皮特性的研究[J]. 中成药, 2008, 30(8):1119-1122.
15. 程怡, 高幼衡, 王利胜, 等. 冰片在不同溶剂载体中透皮速率的动力学特征[J]. 中草药, 2000, 31(8):49-51.

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West China Medical Journal

Study on Effects of Different Penetration Enhancers on the Transdemal Penetration of Miao Medicine Named Diploclisia Affinis

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