Clinical Effect of Silver Dressings on Diabetic Foot Ulcer Infection_West China Medical Journal

Authors：

 GUOChun-lan ,  DENGHong-yan

Outpatient Surgery, Central People's Hospital of Yichang City & the First Clinical Medical College of China Three Gorges University, Yichang, Hubei 443003, P. R. China;

Corresponding author：

DENGHong-yan, Email: 1160279690@qq.com

Keywords：

Silver alginate dressing; Diabetic foot ulcer; Wound infection; Wound care; Evaluation index

DOI：

10.7507/1002-0179.20140495

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To observe the effect of silver dressings on treating diabetic foot ulcer infection. Methods A total of 105 patients with diabetic foot ulcers treated from May 2012 to April 2014 were randomly divided into two groups:group A and B. Patients in group A were treated with imported silver ion alginate dressing, while group B was treated with domestic nanometer silver dressing. All patients were given basic treatment, and the effect of silver dressing was evaluated by observing bacterial clearance rate and wound healing score. Results There were significant improvement in bacterial clearance rate and wound healing score in both two groups after treatment. The bacterial clearance rate was similar between the two groups (P>0.05). However, the descending trend of wound healing score in group A was significantly more obvious than group B (P<0.01). Conclusion Both two silver dressings are effective in the treatment of diabetic foot ulcer infection, but the effectiveness of silver ion alginate dressing is superior. Bacterial clearance rate and wound healing score are objective and applicable index to evaluate the treatment effects of silver dressing.

Citation： GUOChun-lan, DENGHong-yan. Clinical Effect of Silver Dressings on Diabetic Foot Ulcer Infection. West China Medical Journal, 2014, 29(9): 1611-1614. doi: 10.7507/1002-0179.20140495 Copy

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6.	Schulze HJ,Lane C,Charles H,et al.Evaluating a superabsorbent hydropolymer dressing for exuding venous leg ulcers[J].J Wound Care,2001,10(1):511-518.
7.	Du Toit DF,Page BJ.An in vitro evaluation of the cell toxicity of honey and silver dressings[J].J Wound Care,2009,18(9):383-389.
8.	Percival SL,Woods E,Nutekpor M,et al.Prevalence of silver resistance in bacteria isolated from diabetic foot ulcers and efficacy of silver-containing wound dressings[J].Ostomy Wound Manage,2008,54(3):30-40.
9.	National Pressure Ulcer Advisory Panel(2012-02-28)[(2014-07-01)].http://www.npuap.org/resources/educational-and-clinical-resources/push-tool/push-tool/.
10.	Woodward M.Silver dressing in wound healing:what is the evidence?[J].Primary Intention,2005,13(4):153-160.
11.	Amin RM,Mohamed MB,Ramadan MA,et al.Rapid and sensitive microplate assay for screening the effect of silver and gold nanoparticles on bacteria[J].Nanomedicine (Lond),2009,4(6):637-643.
12.	Lansdown AB.A review of the use of silver in wound care:facts and fallacies[J].Br J Nurs,2004,13(Suppl6):S6-S19.
13.	Vigneshwaran N,Nachane RP,Balasubramanya RH,et al.A novel one-pot "green" synthesis of stable silver nanoparticles using soluble starch[J].Carbohydr Res,2006,341(12):2012-2018.
14.	Tien DC,Tseng KH,Liao CY,et al.Colloidal silver fabrication using the spark discharge system and its antimicrobial effect on Staphylococcus aureus[J].Med Eng Phys,2008,30(8):948-952.
15.	Agren MS,Mirastschijski U,Karlsmark T,et al.Topical synthetic inhibitor of matrix metalloproteinases delays epidermal regeneration of human wounds[J].Exp Dermatol,2001,10(5):337-348.
16.	郭春兰,邓红艳,贺莉,等.银离子藻酸盐抗菌敷料治疗延迟愈合伤口的疗效[J].广东医学,2014,35(8):1296-1298.
17.	Gardner SE,Frantz RA,Bergquist S,et al.A prospective study of the pressure ulcer scale for healing (PUSH)[J].J Gerontol A Biol Sci Med Sci,2005,60(1):93-97.
18.	蒋琪霞,李晓华,周昕,等.三乙醇胺乳膏湿敷创伤伤口的疗效评价及其愈合计分的可行性分析[J].护理学报,2012,19(13):53-57.

1. Nelson EA,O'meara S,Craig D,et al.A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers[J].Health Technol Assess,2006,10(12):iii-iiv,ix-x,1-221.
2. Lansdown AB.Silver.l:its antibacterial properties and mechanism of action[J].J Wound Care,2002,11(4):125-130.
3. Jude EB,Apelqvist J,Spraul M,et al.Prospective randomized controlled study of hydrofiber dressing containing ionic silver or calcium alginate dressings in non-ischaemic diabetic foot ulcers[J].Diabet Med,2007,24(3):280-288.
4. Repoet of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus[J].Diabetes Care,1997,20(7):1183-1197.
5. Ghanassia E,Villon L,Thuan Dit Dieudonné JF,et al.Long-term outcome and disability of diabetic patients hospitalized for diabetic foot ulcers:a 6.5-year follow-up study[J].Diabetes Care,2008,31(7):1288-1292.
6. Schulze HJ,Lane C,Charles H,et al.Evaluating a superabsorbent hydropolymer dressing for exuding venous leg ulcers[J].J Wound Care,2001,10(1):511-518.
7. Du Toit DF,Page BJ.An in vitro evaluation of the cell toxicity of honey and silver dressings[J].J Wound Care,2009,18(9):383-389.
8. Percival SL,Woods E,Nutekpor M,et al.Prevalence of silver resistance in bacteria isolated from diabetic foot ulcers and efficacy of silver-containing wound dressings[J].Ostomy Wound Manage,2008,54(3):30-40.
9. National Pressure Ulcer Advisory Panel(2012-02-28)[(2014-07-01)].http://www.npuap.org/resources/educational-and-clinical-resources/push-tool/push-tool/.
10. Woodward M.Silver dressing in wound healing:what is the evidence?[J].Primary Intention,2005,13(4):153-160.
11. Amin RM,Mohamed MB,Ramadan MA,et al.Rapid and sensitive microplate assay for screening the effect of silver and gold nanoparticles on bacteria[J].Nanomedicine (Lond),2009,4(6):637-643.
12. Lansdown AB.A review of the use of silver in wound care:facts and fallacies[J].Br J Nurs,2004,13(Suppl6):S6-S19.
13. Vigneshwaran N,Nachane RP,Balasubramanya RH,et al.A novel one-pot "green" synthesis of stable silver nanoparticles using soluble starch[J].Carbohydr Res,2006,341(12):2012-2018.
14. Tien DC,Tseng KH,Liao CY,et al.Colloidal silver fabrication using the spark discharge system and its antimicrobial effect on Staphylococcus aureus[J].Med Eng Phys,2008,30(8):948-952.
15. Agren MS,Mirastschijski U,Karlsmark T,et al.Topical synthetic inhibitor of matrix metalloproteinases delays epidermal regeneration of human wounds[J].Exp Dermatol,2001,10(5):337-348.
16. 郭春兰,邓红艳,贺莉,等.银离子藻酸盐抗菌敷料治疗延迟愈合伤口的疗效[J].广东医学,2014,35(8):1296-1298.
17. Gardner SE,Frantz RA,Bergquist S,et al.A prospective study of the pressure ulcer scale for healing (PUSH)[J].J Gerontol A Biol Sci Med Sci,2005,60(1):93-97.
18. 蒋琪霞,李晓华,周昕,等.三乙醇胺乳膏湿敷创伤伤口的疗效评价及其愈合计分的可行性分析[J].护理学报,2012,19(13):53-57.

West China Medical Journal

Clinical Effect of Silver Dressings on Diabetic Foot Ulcer Infection

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