Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant_West China Medical Journal

Authors：

 LIUGui-tao ^1,2 , TAOYing ¹ ,  WANGQian ³ , WEIYan-hua ² , NIELi-ping ² , YINWan-bin ² , WUYan-pin ² , WANGXiao-hua ² , YUWen-long ²

1. Occupational Diseases Prevention and Treatment Institution, the Fifth Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;
2. Medical School, Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;
3. College of Public Health; Xinjiang Medical University, Urumqi, Xinjiang 830011, P. R. China;

Corresponding author：

WANGQian, Email: 387788761@qq.com

Keywords：

Budesonide formoterol inhalant; Allergic rhinitis; Bronchial asthma; Nitric oxide in the exhaled gas

DOI：

10.7507/1002-0179.20150077

Video：

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Objective To observe the effect of Budesonide formoterol inhalant on teenager patients with allergic rhinitis accompanied with asthma. Methods Forty-five teenager patients with allergic rhinitis accompanied with asthma treated between January 2012 and December 2013 were randomly divided into general treatment group, budesonide group and budesonide formoterol group, with 15 patients in each. Another 15 subjects undergoing physical examination were designated as the control group. Besides routine treatment, the budesonide group was also treated with budesonide inhalation at 100-200 μg twice a day, and the budesonide formoterol group was also treated with budesonide formoterol inhalation at 160 μg and 4.5 μg twice a day. The course of treatment lasted for four weeks. The patients were followed up for four weeks after the use of medicine halted. After treatment, exhaled nitric oxide (NO) examination were performed. Results The amount of NO in the exhaled gas in all the three treatment groups were significantly different from the control group (P<0.05), and it was also significantly different between the Budesonide group and the budesonide formoterol group (P<0.05). Conclusion Budesonide formoterol inhalant has a good effect on teenager patients with allergic rhinitis accompanied with asthma in terms of improving exhaled NO.

Citation： LIUGui-tao, TAOYing, WANGQian, WEIYan-hua, NIELi-ping, YINWan-bin, WUYan-pin, WANGXiao-hua, YUWen-long. Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant. West China Medical Journal, 2015, 30(2): 246-249. doi: 10.7507/1002-0179.20150077 Copy

1.	韩德民, 张罗, 黄丹, 等. 我国11个城市变应性鼻炎自报患病率调查[J]. 中华耳鼻咽喉头颈外科杂志, 2007, 42(5):378-384.
2.	Guerra S, Sherrill DL, Martinez FD, et al. Rhinitis as an Independent risk factor for adultonset asthma[J]. J Allergy Clin Immunol, 2002, 109(3):419-425.
3.	Gaugris S, Sazonov-Kocevar V, Thomas M. Burden of concomitant allergic rhinitis in adults with asthma[J]. J Asthma, 2006, 43(1):1-7.
4.	王惠妩, 向阳冰, 陈璇, 等. 新疆地区哮喘与变应性鼻炎患者过敏原检测及相关性分析[J]. 新疆医科大学学报, 2007, 30(10):1086-1088.
5.	杨柳, 刘世喜. 变应性鼻炎的特异性免疫治疗[J]. 华西医学, 2012, 27(10):1582-1584.
6.	张虹婷, 余蓉, 孟娟, 等. 变应性鼻炎皮肤点刺试验分析[J]. 华西医学, 2014, 29(2):334-336.
7.	唐秀纯, 周云霞. 小儿哮喘健康教育的效果评价[J]. 华西医学, 2010, 25(8):1561-1562.
8.	奚玲. 过敏性鼻炎未成年患者常见吸入性变应原分析[J]. 华西医学, 2014, 29(4):710-713.
9.	谢红. 卡介菌多糖核酸治疗小儿咳嗽变异性哮喘[J]. 华西医学, 2009, 24(2):421-422.
10.	王晓霞, 苏娴, 包勇. 呼出气一氧化氮检测在支气管哮喘中的应用[J]. 华西医学, 2010, 25(9):1765-1768.
11.	胡鑫, 沈唯薇. 难治性哮喘中Th1/Th2失衡机制[J]. 华西医学, 2011, 26(9):1428-1431.
12.	彭向东, 何晟. 支气管哮喘合并过敏性鼻炎的中西医结合治疗[J]. 临床和实验医学杂志, 2013, 12(14):1118-1119.
13.	Rottem M. Allergic rhinitis and its impaction asthma[J]. Harefuah, 2010, 149(6):402-403.
14.	孙勇, 蒋捍东. 过敏性鼻炎与哮喘患者血清黏附分子及白细胞介素的研究[J]. 中国医药, 2009, 4(6):405-407.
15.	王晓君. 支气管哮喘合并变应性鼻炎共治的临床观察[D]. 唐山:华北煤炭医学院, 2010.
16.	杜娟, 陈冰蓉, 周建, 等. 孟鲁司特治疗儿童变应性鼻炎与哮喘的疗效观察[J]. 中国现代应用药学, 2008, 25(增刊1):679-681.
17.	马敏, 李奕, 倪殿涛, 等. 变应性鼻炎合并哮喘患者糖皮质激素鼻吸入治疗对哮喘发作的影响[J]. 武警医学, 2003, 14(9):521-524.
18.	王栋. 不同药物对小儿哮喘的疗效对比研究[J]. 华西医学, 2010, 25(2):345-346.

1. 韩德民, 张罗, 黄丹, 等. 我国11个城市变应性鼻炎自报患病率调查[J]. 中华耳鼻咽喉头颈外科杂志, 2007, 42(5):378-384.
2. Guerra S, Sherrill DL, Martinez FD, et al. Rhinitis as an Independent risk factor for adultonset asthma[J]. J Allergy Clin Immunol, 2002, 109(3):419-425.
3. Gaugris S, Sazonov-Kocevar V, Thomas M. Burden of concomitant allergic rhinitis in adults with asthma[J]. J Asthma, 2006, 43(1):1-7.
4. 王惠妩, 向阳冰, 陈璇, 等. 新疆地区哮喘与变应性鼻炎患者过敏原检测及相关性分析[J]. 新疆医科大学学报, 2007, 30(10):1086-1088.
5. 杨柳, 刘世喜. 变应性鼻炎的特异性免疫治疗[J]. 华西医学, 2012, 27(10):1582-1584.
6. 张虹婷, 余蓉, 孟娟, 等. 变应性鼻炎皮肤点刺试验分析[J]. 华西医学, 2014, 29(2):334-336.
7. 唐秀纯, 周云霞. 小儿哮喘健康教育的效果评价[J]. 华西医学, 2010, 25(8):1561-1562.
8. 奚玲. 过敏性鼻炎未成年患者常见吸入性变应原分析[J]. 华西医学, 2014, 29(4):710-713.
9. 谢红. 卡介菌多糖核酸治疗小儿咳嗽变异性哮喘[J]. 华西医学, 2009, 24(2):421-422.
10. 王晓霞, 苏娴, 包勇. 呼出气一氧化氮检测在支气管哮喘中的应用[J]. 华西医学, 2010, 25(9):1765-1768.
11. 胡鑫, 沈唯薇. 难治性哮喘中Th1/Th2失衡机制[J]. 华西医学, 2011, 26(9):1428-1431.
12. 彭向东, 何晟. 支气管哮喘合并过敏性鼻炎的中西医结合治疗[J]. 临床和实验医学杂志, 2013, 12(14):1118-1119.
13. Rottem M. Allergic rhinitis and its impaction asthma[J]. Harefuah, 2010, 149(6):402-403.
14. 孙勇, 蒋捍东. 过敏性鼻炎与哮喘患者血清黏附分子及白细胞介素的研究[J]. 中国医药, 2009, 4(6):405-407.
15. 王晓君. 支气管哮喘合并变应性鼻炎共治的临床观察[D]. 唐山:华北煤炭医学院, 2010.
16. 杜娟, 陈冰蓉, 周建, 等. 孟鲁司特治疗儿童变应性鼻炎与哮喘的疗效观察[J]. 中国现代应用药学, 2008, 25(增刊1):679-681.
17. 马敏, 李奕, 倪殿涛, 等. 变应性鼻炎合并哮喘患者糖皮质激素鼻吸入治疗对哮喘发作的影响[J]. 武警医学, 2003, 14(9):521-524.
18. 王栋. 不同药物对小儿哮喘的疗效对比研究[J]. 华西医学, 2010, 25(2):345-346.

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West China Medical Journal

Change of Nitric Oxide in the Exhaled Gas of Teenager Patients with Allergic Rhinitis Accompanied with Asthma Treated by Budesonide Formoterol Inhalant

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