Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon_West China Medical Journal

Authors：

 GAOXue-mei , ZHOUPing , ZHUYi-lin ,  HEYi

Department of Obstetrics, Wuhan NO. 1 Hospital, Wuhan, Hubei 430022, P. R. China;

Corresponding author：

HEYi, Email: zxghy@163.com

Keywords：

Induction labor; Ethacridine; Cook cervical ripening balloon

DOI：

10.7507/1002-0179.20150135

Video：

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Objective To probe into the clinical effects of intra-amniotic injection of ethacridine with Cook cervical ripening balloon in terminating mid-pregnancy. Methods A total of 150 mid-pregnant women who required induction of labor from January 2011 to December 2012 were randomly divided into two groups: observation group (intra-amniotic injection of ethacridine with Cook cervical ripening balloon) and control group (intra-amniotic injection of ethacridine). Results The time of labor induction was obviously shorter in the observation group than the control group [the time from using ethacridine to contraction: （29.68±4.17） vs (33.60±5.38) hours, P<0.05; total process: (7.63±2.30) vs (9.86±3.20) hours, P<0.05], and the residual rate of placental membranes [28.6% (10/35) vs 56.4%(22/39), P<0.05] was significantly lower. But there was no significant difference in postpartum hemorrhage [(81.60±17.64) vs (83.82±15.08 ) mL, P>0.05] and rate of success [100.0% (35/35) vs 94.9% (37/39), P>0.05]. Conclusion Terminating mid-pregnancy by intra-amniotic injection of ethacridine with Cook cervical ripening balloon has the advantages of shorter time and less pain, which deserves clinical application widely.

Citation： GAOXue-mei, ZHOUPing, ZHUYi-lin, HEYi. Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon. West China Medical Journal, 2015, 30(3): 477-479. doi: 10.7507/1002-0179.20150135 Copy

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2.	Atad J, Hallak M, Auslender R, et al. Arandomized com-parison of prostaglandin E₂, oxytocin, and double-balloon devicein inducing labor[J]. Obstet Gynecol, 1996, 87(2):223-227.
3.	Vellekoop J, Vrouenraets FP, Van DJ, et al. Indacations and results of labor induction in nulliparous women:an interview among obstetricians, residents and clinical midwives[J]. Eur J Obstet Gynecol Reprod Biol, 2009, 146(2):156-159.
4.	Zhuang YL, Chen XY, Huang LL. Mifepristone may shorten the induction-to-abortion time for termination of second-trimester pregnancies by ethacridine lactate[J]. Contraception, 2012, 85(2):211-217.
5.	孙燕茹. 米非司酮与米索前列醇联合水囊用于中期引产的临床观察[J]. 中国医药导报, 2011, 8(1):153-154.
6.	莫言香, 徐红梅, 李娜, 等. 欣母佩用于产后出血治疗的临床效果分析[J]. 中国妇幼保健, 2012, 27(3):343-345.
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9.	范翠芳, 张正娥, 明蕾, 等. COOK双球囊与缩宫素促宫颈成熟并引产的对照研究[J]. 重庆医学, 2012, 41(36):3820-3822.
10.	窦娜, 周红辉, 高志英. Cook宫颈扩张球囊用于妊娠晚期促宫颈成熟的临床研究[J]. 军医进修学院学报, 2012, 33(8):836-838.
11.	Cromi A, Ghezzi F, Uccella S, et al. A randomized trial of preinduction cervical ripening:dinoprostone vaginal insert versus double-balloon catheter[J]. Am J Obstet Gynecol, 2012, 207(2):1-7.
12.	Boyon C, Monsarrat N, Clouqueur E, et al. Cervical ripening:is there an advantage for a double-balloon device in labor induction?[J]. Gynecol Obstet Fertil, 2014, 42(10):674-680.
13.	Jozwiak M, Oude RK, Benthem M, et al. Foley catheter versus vaginal prostaglandin E₂ gel for induction of labour at term (PROBAAT trial):an open-label, randomised controlled trial[J]. Lancet, 2011, 378(9809):2095-2103.
14.	陈飞, 刘欣燕, 彭萍, 等. 地诺前列酮栓配伍依沙吖啶与单用依沙丫啶在中期妊娠引产中的有效性和安全性比较[J]. 中国医学科学院学报, 2010, 32(5):505-508.
15.	Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery[J]. N Engl J Med, 2004, 351(25):2581-2589.
16.	Ravasia DJ, Wood SL, Pollard JK. Uterine rupture during induced trial of labor among women with previous cesarean delivery[J]. Am J Obstet Gynecol, 2000, 183(5):1176-1179.
17.	Bujold E, Blackwell SC, Gauthier RJ. Cervical ripening with transcervical Foley catheter and the risk of uterine rupture[J]. Obstet Gynecol, 2004, 103(1):18-23.
18.	杨茗, 李云秀, 柏智, 等. 人工破膜联合COOK球囊在足月引产中的疗效观察[J]. 当代医学, 2013, 19(30):27-28.

1. Kehl S, Welzel G, Ehard A, et al. Women's acceptance of a double-balloon device as an additional method for inducing labour[J]. Eur J Obstet Gynecol Reprod Biol, 2013, 168(1):30-35.
2. Atad J, Hallak M, Auslender R, et al. Arandomized com-parison of prostaglandin E₂, oxytocin, and double-balloon devicein inducing labor[J]. Obstet Gynecol, 1996, 87(2):223-227.
3. Vellekoop J, Vrouenraets FP, Van DJ, et al. Indacations and results of labor induction in nulliparous women:an interview among obstetricians, residents and clinical midwives[J]. Eur J Obstet Gynecol Reprod Biol, 2009, 146(2):156-159.
4. Zhuang YL, Chen XY, Huang LL. Mifepristone may shorten the induction-to-abortion time for termination of second-trimester pregnancies by ethacridine lactate[J]. Contraception, 2012, 85(2):211-217.
5. 孙燕茹. 米非司酮与米索前列醇联合水囊用于中期引产的临床观察[J]. 中国医药导报, 2011, 8(1):153-154.
6. 莫言香, 徐红梅, 李娜, 等. 欣母佩用于产后出血治疗的临床效果分析[J]. 中国妇幼保健, 2012, 27(3):343-345.
7. ACOG Committee on Practice Bulletins-Obstetrics. ACOG practice bulletin No.107:induction of labor[J]. Obstet Gynecol, 114(2):386-397.
8. Society of Obstetricians and Gynaecologists of Canada. SOGC clinical practice guidelines. Guidelines for vaginal birth after previous caesarean birth. Number 155(Replaces guideline Number 147), February 2005[J]. Int J Gynaecol Obstet, 2005, 89(3):319-331.
9. 范翠芳, 张正娥, 明蕾, 等. COOK双球囊与缩宫素促宫颈成熟并引产的对照研究[J]. 重庆医学, 2012, 41(36):3820-3822.
10. 窦娜, 周红辉, 高志英. Cook宫颈扩张球囊用于妊娠晚期促宫颈成熟的临床研究[J]. 军医进修学院学报, 2012, 33(8):836-838.
11. Cromi A, Ghezzi F, Uccella S, et al. A randomized trial of preinduction cervical ripening:dinoprostone vaginal insert versus double-balloon catheter[J]. Am J Obstet Gynecol, 2012, 207(2):1-7.
12. Boyon C, Monsarrat N, Clouqueur E, et al. Cervical ripening:is there an advantage for a double-balloon device in labor induction?[J]. Gynecol Obstet Fertil, 2014, 42(10):674-680.
13. Jozwiak M, Oude RK, Benthem M, et al. Foley catheter versus vaginal prostaglandin E₂ gel for induction of labour at term (PROBAAT trial):an open-label, randomised controlled trial[J]. Lancet, 2011, 378(9809):2095-2103.
14. 陈飞, 刘欣燕, 彭萍, 等. 地诺前列酮栓配伍依沙吖啶与单用依沙丫啶在中期妊娠引产中的有效性和安全性比较[J]. 中国医学科学院学报, 2010, 32(5):505-508.
15. Landon MB, Hauth JC, Leveno KJ, et al. Maternal and perinatal outcomes associated with a trial of labor after prior cesarean delivery[J]. N Engl J Med, 2004, 351(25):2581-2589.
16. Ravasia DJ, Wood SL, Pollard JK. Uterine rupture during induced trial of labor among women with previous cesarean delivery[J]. Am J Obstet Gynecol, 2000, 183(5):1176-1179.
17. Bujold E, Blackwell SC, Gauthier RJ. Cervical ripening with transcervical Foley catheter and the risk of uterine rupture[J]. Obstet Gynecol, 2004, 103(1):18-23.
18. 杨茗, 李云秀, 柏智, 等. 人工破膜联合COOK球囊在足月引产中的疗效观察[J]. 当代医学, 2013, 19(30):27-28.

West China Medical Journal

Clinical Observation of Terminating Mid-pregnancy by Intra-amniotic Injection of Ethacridine with Cook Cervical Ripening Balloon

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