A Study of Cytokine Changes in the Cerebrospinal Fluid of Mesial Temporal Lobe Epilepsy Patients with Hippocampal Sclerosis_West China Medical Journal

Authors：

 YANGHong-yu ¹ , SHAOXue ² , HUANGCheng ¹ , YANBo ¹ , WANGRui ¹ , ZHOUHong-yu ¹ ,  LIJin-mei ¹

1. Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China;
2. National Key Laboratory of Biologic Treatment, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

LIJin-mei, Email: jinmeili-neuro@qq.com

Keywords：

Mesial temporal lobe epilepsy; Hippocampal sclerosis; Cytokines

DOI：

10.7507/1002-0179.20150178

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To study the cytokine changes in the cerebrospinal fluid (CSF) of mesial temporal lobe epilepsy (MTLE) patients, and the mechanism of the development of hippocampal sclerosis. Methods Fifty MTLE patients who sought treatment from January 2013 to March 2014 were included in the study. Clinical features were investigated. All CSF samples of the 59 patients along with 19 samples of the control group were tested for 12 common cytokines using a chemokine magnetic bead panel. Data were statistically analyzed. Results Clinical features showed no significant difference between hippocampal sclerosis and non-hippocampal sclerosis patients. Interleukin (IL)-1 receptor antagonist (RA), IL-4 and IL-9 expression decreased, and tumor necrosis factor (TNF)-α, IL-3 and IL-5 expression increased. Up-regulation of TNF-α was significantly different between hippocampal sclerosis and non-hippocampal sclerosis patients. Conclusion IL-1RA, IL-3, IL-4, IL-5 and IL-9 changes may be non-specific seizure-related cytokine regulation. TNF-α is associated with hippocampal sclerosis pathology. TNF-α is a possible pathological element in hippocampal sclerosis development.

Citation： YANGHong-yu, SHAOXue, HUANGCheng, YANBo, WANGRui, ZHOUHong-yu, LIJin-mei. A Study of Cytokine Changes in the Cerebrospinal Fluid of Mesial Temporal Lobe Epilepsy Patients with Hippocampal Sclerosis. West China Medical Journal, 2015, 30(4): 609-612. doi: 10.7507/1002-0179.20150178 Copy

1.	Engel J. Mesial temporal lobe epilepsy:what have we learned?[J]. Neuroscientist, 2001, 7(4):340-352.
2.	Eid T, Thomas MJ, Spencer DD, et al. Loss of glutamine synthetase in the human epileptogenic hippocampus:possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy[J]. Lancet, 2004, 363(942):28-37.
3.	华勇. MRI对诊断癫痫患者海马硬化的应用价值[J]. 中国实用医药, 2011, 6(26):30-31.
4.	李文华, 沈天真, 陈星荣, 等. 海马硬化的MRI诊断[J]. 中华放射学杂志, 2000(12):44-47.
5.	Yang T, Zhou D, Stefan H. Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive:uncontrolled inflammation drives disease progression?[J]. J Neurol Sci, 2010, 296(1/2):1-6.
6.	Cohen-Gadol AA, Wilhelmi BG, Colliqnon F, et al. Long-term outcome of epilepsy surgery among 399 patients with nonlesional seizure foci including mesial temporal lobe sclerosis[J]. J Neurosurg, 2006, 104(4):513-524.
7.	Shorvon SD. The etiologic classification of epilepsy[J]. Epilepsia, 2011, 52(6):1052-1057.
8.	Isnard J, Bourdillon P. Morphological imaging of the hippocampus in epilepsy[J]. Rev Neurol (Paris), 2015:S0035-3787(15)00027-2.
9.	Blumcke I, Cross JH, Spreafico R. The international consensus classification for hippocampal sclerosis:an important step towards accurate prognosi[J]. Lancet Neurol, 2013, 12(9):844-846.
10.	Vezzani A, French J, Bartfai T, et al. The role of inflammation in epilepsy[J]. Nat Rev Neurol, 2011, 7(1):31-40.
11.	Silveira G, de Oliveira AC, Teixeira AL. Insights into inflammation and epilepsy from the basic and clinical science[J]. J Clin Neurosci, 2012, 19(8):1071-1075.
12.	Sinha S, Patil SA, Jayalekshmy V, et al. Do cytokines have any role in epilepsy?[J]. Epilepsy Res, 2008, 82(2/3):171-176.
13.	Kan AA, de Jager W, de Wit M, et al. Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines[J]. J Neuroinflammation, 2012, 9:207.
14.	卢峰, 王如密. 颞叶癫痫海马硬化凋亡机制的研究进展[J]. 福州总医院学报, 2007(增刊1):132-134.
15.	Teocchi MA, Ferreira AÉ, da Luz de Oliveira EP, et al. Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients[J]. J Neuroinflammation, 2013, 10:53.
16.	Zhao B, Schwartz JP. Involvement of cytokines in normal CNS development and neurological diseases:recent progress and perspectives[J]. J Neurosci Res, 1998, 52(1):7-16.
17.	McCoy MK, Tansey MG. TNF signaling inhibition in the CNS:implications for normal brain function and neurodegenerative disease[J]. J Neuroinflammation, 2008, 5:45.
18.	Baune BT, Konrad C, Grotegerd D, et al. Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals[J]. Biol Psychiatry, 2012, 72(8):655-662.
19.	Pozniak PD, White MK, Khalili K. TNF-α/NF-κB signaling in the CNS:possible connection to EPHB2[J]. J Neuroimmune Pharmacol, 2014, 9(2):133-141.
20.	Bao Y, Cao X. The immune potential and immunopathology of cytokine-producing B cell subsets:a comprehensive review[J].J Autoimmun, 2014, 55:10-23.

1. Engel J. Mesial temporal lobe epilepsy:what have we learned?[J]. Neuroscientist, 2001, 7(4):340-352.
2. Eid T, Thomas MJ, Spencer DD, et al. Loss of glutamine synthetase in the human epileptogenic hippocampus:possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy[J]. Lancet, 2004, 363(942):28-37.
3. 华勇. MRI对诊断癫痫患者海马硬化的应用价值[J]. 中国实用医药, 2011, 6(26):30-31.
4. 李文华, 沈天真, 陈星荣, 等. 海马硬化的MRI诊断[J]. 中华放射学杂志, 2000(12):44-47.
5. Yang T, Zhou D, Stefan H. Why mesial temporal lobe epilepsy with hippocampal sclerosis is progressive:uncontrolled inflammation drives disease progression?[J]. J Neurol Sci, 2010, 296(1/2):1-6.
6. Cohen-Gadol AA, Wilhelmi BG, Colliqnon F, et al. Long-term outcome of epilepsy surgery among 399 patients with nonlesional seizure foci including mesial temporal lobe sclerosis[J]. J Neurosurg, 2006, 104(4):513-524.
7. Shorvon SD. The etiologic classification of epilepsy[J]. Epilepsia, 2011, 52(6):1052-1057.
8. Isnard J, Bourdillon P. Morphological imaging of the hippocampus in epilepsy[J]. Rev Neurol (Paris), 2015:S0035-3787(15)00027-2.
9. Blumcke I, Cross JH, Spreafico R. The international consensus classification for hippocampal sclerosis:an important step towards accurate prognosi[J]. Lancet Neurol, 2013, 12(9):844-846.
10. Vezzani A, French J, Bartfai T, et al. The role of inflammation in epilepsy[J]. Nat Rev Neurol, 2011, 7(1):31-40.
11. Silveira G, de Oliveira AC, Teixeira AL. Insights into inflammation and epilepsy from the basic and clinical science[J]. J Clin Neurosci, 2012, 19(8):1071-1075.
12. Sinha S, Patil SA, Jayalekshmy V, et al. Do cytokines have any role in epilepsy?[J]. Epilepsy Res, 2008, 82(2/3):171-176.
13. Kan AA, de Jager W, de Wit M, et al. Protein expression profiling of inflammatory mediators in human temporal lobe epilepsy reveals co-activation of multiple chemokines and cytokines[J]. J Neuroinflammation, 2012, 9:207.
14. 卢峰, 王如密. 颞叶癫痫海马硬化凋亡机制的研究进展[J]. 福州总医院学报, 2007(增刊1):132-134.
15. Teocchi MA, Ferreira AÉ, da Luz de Oliveira EP, et al. Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients[J]. J Neuroinflammation, 2013, 10:53.
16. Zhao B, Schwartz JP. Involvement of cytokines in normal CNS development and neurological diseases:recent progress and perspectives[J]. J Neurosci Res, 1998, 52(1):7-16.
17. McCoy MK, Tansey MG. TNF signaling inhibition in the CNS:implications for normal brain function and neurodegenerative disease[J]. J Neuroinflammation, 2008, 5:45.
18. Baune BT, Konrad C, Grotegerd D, et al. Tumor necrosis factor gene variation predicts hippocampus volume in healthy individuals[J]. Biol Psychiatry, 2012, 72(8):655-662.
19. Pozniak PD, White MK, Khalili K. TNF-α/NF-κB signaling in the CNS:possible connection to EPHB2[J]. J Neuroimmune Pharmacol, 2014, 9(2):133-141.
20. Bao Y, Cao X. The immune potential and immunopathology of cytokine-producing B cell subsets:a comprehensive review[J].J Autoimmun, 2014, 55:10-23.

Previous Article
Research Study on Quality of Life for Caregivers of Patients with Alzheimer's Disease
Next Article
Video-electroencephalography Characteristics of Old Patients with Epilepsy

West China Medical Journal

A Study of Cytokine Changes in the Cerebrospinal Fluid of Mesial Temporal Lobe Epilepsy Patients with Hippocampal Sclerosis

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content