Effect of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cerebral Dysfunction Induced by Traumatic Brain Injury_West China Medical Journal

Authors：

 LUOChang-bin ,  CAOLing-hong , YANGCheng-hao

Emergency Department, the Fourth People's Hospital of Zigong, Zigong, Sichuan 643000, P. R. China;

Corresponding author：

CAOLing-hong, Email: 591765270@qq.com

Keywords：

Hyperbaric oxygen; Nimodipine; Traumatic brain injury; Cerebral dysfunction

DOI：

10.7507/1002-0179.20150292

Video：

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Objective To study the effect of hyperbaric oxygen combined with nimodipine in the treatment of cerebral dysfunction resulted from traumatic brain injury. Method We retrospectively collected and analyzed the data of 124 patients with cerebral dysfunction induced by traumatic brain injury, admitted to the Neurosurgery Department during February 2011 to February 2014. All the patients were divided into the traditional treatment group (n=45), the traditional treatment with hyperbaric oxygen group (HBO group, n=40) and the traditional treatment with nimodipine and hyperbaric oxygen group (integrated group, n=39). The differences among the three groups in neurological injury severity evaluated by National Institute of Health Stroke Scale and the cerebral blood flow were recorded and analyzed at three time points (before the treatment, 2 and 4 weeks after treatment). Results There was no significant difference in neurological injury severity and cerebral blood flow among these three groups before treatment (P>0.05). Evaluated at 2 and 4 weeks after treatments, the neurological injury severity of HBO group and integrated group were significantly less than the traditional treatment group (P<0.05); the neurological severity score of integrated group was significantly lower than the HBO group (P<0.05); the cerebral blood flow of HBO group and integrated group were significantly higher than the traditional treatment group (P<0.05); and the cerebral blood flow of integrated group was significantly higher than the HBO group (P<0.05). Conclusions The combination therapy of hyperbaric oxygen combined with nimodipine is effective in the treatment of cerebral dysfunction induced by traumatic brain injury, because of its attenuation of neurological injury severity and increase of cerebral blood flow.

Citation： LUOChang-bin, CAOLing-hong, YANGCheng-hao. Effect of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cerebral Dysfunction Induced by Traumatic Brain Injury. West China Medical Journal, 2015, 30(6): 1015-1018. doi: 10.7507/1002-0179.20150292 Copy

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1. 张建华, 杨文东. 高压氧对重型闭合性颅脑损伤患者氧自由基和红细胞CR1分子表达的影响[J]. 滨州医学院学报, 2007, 30(2):157-159.
2. 王忠诚. 王忠诚神经外科学[M]. 武汉:湖北科学技术出版社, 2004:66-67.
3. Weyland A, Buhre W, Grund S, et al. Cerebrovascular tone rather than intracranial pressure determines the effective downstream pressure of the cerebral circulation in the absence of intracranial hypertension[J]. J Neurosurg Anesthesiol, 2000, 12(3):210-216.
4. Sukoff MH. Effects of hyperbaric oxygenation[J]. J Neurosurg, 2001, 95(3):544-546.
5. Rockswold SB, Rockswold GL, Vargo JM, et al. Effects of hyperbaric oxygenation therapy on cerebral metabolism and intracranial pressure in severely brain injured patients[J]. J Neurosurg, 2001, 94(3):403-411.
6. 高春锦, 杨捷运, 瞿晓辉. 高压氧医学基础与临床[M]. 北京:人民卫生出版社, 2008:300-309.
7. 易治, 翁其彪. 高压氧医学教程[M]. 广州:暨南大学出版社, 2012:28-31.
8. 张艳平, 杨崇选, 任家庚, 等. 早期高压氧治疗弥漫性轴索损伤的疗效分析[J]. 牡丹江医学院学报, 2013, 34(5):17-19.
9. 胡青, 许小林, 陈益番, 等. 法舒地尔联合尼莫地平治疗蛛网膜下腔出血(SAH)的疗效及安全性探讨[J]. 中外医疗, 2013, 32(15):109, 111.
10. 杨鹤云, 杨正宇, 张红莲, 等. 尼莫地平对高血压脑出血患者脑血肿,水肿及神经功能恢复的影响[J]. 中国医药科学, 2015, 5(1):121-123.
11. 杨玉亭, 许爱琴, 李光华. 尼莫地平对大鼠急性脑缺血再灌注损伤的保护机制[J]. 齐齐哈尔医学院学报, 2006, 27(2):139-140.
12. 封林森, 马建华, 刘艺春, 等. 高压氧联合尼莫地平治疗对颅脑损伤血液流变学的影响[J]. 中国血液流变学杂志, 2008, 18(1):62-63, 95.
13. Sun BL, Xia ZL, Yang MF, et al. Effects of Ginkgo biloba extract on somatosensory evoked potential, nitric oxide levels in serum and brain tissue in rats with cerebral vasospasm after subarachnoid hemorrhage[J]. Clin Hemorheol Mieroeire, 2000, 23(2/3/4):139-144.
14. 陈瑾歆, 唐聪明. 氧自由基的研究进展[J]. 海南医学院学报, 2004, 10(3):206-208.
15. Román GC, Erkinjuntti T, Wallin A, et al. Subcortical ischaemic vascular dementia[J]. Lancet Neurol, 2002, 1(7):426-436.
16. 薛连璧, 王拥军, 于秋红, 等. 超早期大剂量高压氧治疗急性脑卒中的实验研究[J]. 中国临床神经科学, 2007, 15(6):583-588.
17. 廖驭国. 早期高压氧联合尼莫地平治疗脑弥漫性轴索损伤的疗效观察[J]. 中国伤残医学, 2015, 35(9):112-113.
18. 蔡志春, 黎敏, 李健哲, 等. 尼莫地平对过氧化氢诱导猪脑基底动脉氧化应激损伤的保护作用[J]. 中国临床药理学与治疗学, 2007, 12(8):906-910.

West China Medical Journal

Effect of Hyperbaric Oxygen Combined with Nimodipine in the Treatment of Cerebral Dysfunction Induced by Traumatic Brain Injury

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