A Meta-analysis of Glucosamine for Osteoarthritis in Asian Population_West China Medical Journal

Authors：

 CHENShi-ju , LIUYuan ,  SHIGui-xiu

Department of Rheumatology, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian 361003, P. R. China;

Corresponding author：

SHIGui-xiu, Email: guixiu.shi@gmail.com

Keywords：

Osteoarthritis; Glucosamine; Asian population; Meta-analysis

DOI：

10.7507/1002-0179.20150466

Video：

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Objective To study the effectiveness and safety of glucosamine for osteoarthritis (OA) in Asian population. Method Databases of PubMed, Embase, CNKI, VIP and Wanfang were searched from the time of establishment till May 2014 and controlled trials of glucosamine compared with placebo or nonsteroidal anti-inflammatory drugs (NSAIDs) were included. Quality evaluation and Meta-analysis by using RevMan 5.1 were performed. Results A total of 17 studies including 2 251 cases were included. The efficiency rate in the glucosamine group was higher than that in the NSAIDs group[OR=3.03, 95% CI (1.78, 5.18), P<0.000 1]. The efficiency rate in the glucosamine combined NSAIDs group was higher than that in the NSAIDs group[OR=4.30,95%CI (1.84,10.06),P=0.000 8]. The safety analysis showed that the adverse event rate in the glucosamine group was lower than that in the NSAIDs group[OR=0.23,95%CI (0.14,0.37),P<0.000 01], while the difference between the glucosamine combined NSAIDs group and the NSAIDs group was not statistically significant[OR=0.84, 95%CI (0.50, 1.41), P=0.50]. Conclusions Compared with NSAIDs, glucosamine is better and safer for OA treatment in Asian population.

Citation： CHENShi-ju, LIUYuan, SHIGui-xiu. A Meta-analysis of Glucosamine for Osteoarthritis in Asian Population. West China Medical Journal, 2015, 30(9): 1627-1632. doi: 10.7507/1002-0179.20150466 Copy

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2.	谢河秋. 盐酸氨基葡萄糖在膝骨性关节炎治疗中的临床观察[J]. 现代预防医学, 2009, 36(11):2161-2162.
3.	Wu D, Huang Y, Gu Y, et al. Efficacies of different preparations of glucosamine for the treatment of osteoarthritis:a meta-analysis of randomised, double-blind, placebo-controlled trials[J]. Int J Clin Pract, 2013, 67(6):585-594.
4.	Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses[J]. BMJ, 2003, 327(7414):557-560.
5.	左川, 杨南萍, 陈咏涛. 硫酸氨基葡萄糖与双氯芬酸治疗膝骨关节炎的临床对照研究[J]. 中华风湿病学杂志, 2003, 7(5):306-308.
6.	张国华, 李桃. 盐酸氨基葡萄糖与双氯芬酸钠缓释片治疗骨性关节炎疗效对比[J]. 广东医学, 2006, 27(12):1907-1908.
7.	崔红霞, 王卫卫, 孟丽华. 盐酸氨基葡萄糖治疗骨关节炎的临床观察[J]. 中国实用医药, 2008, 3(34):163-164.
8.	赵延斌, 林伍伍. 盐酸氨基葡萄糖胶囊治疗膝骨关节炎疗效观察[J]. 中国药师, 2011, 14(9):1314-1315.
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10.	唐一仑, 王坤正, 党晓谦, 等. 盐酸氨基葡萄糖结合塞来昔布治疗膝骨关节炎的疗效观察[J]. 华西医学, 2012, 27(12):1780-1783.
11.	陈作桓. 盐酸氨基葡萄糖与双氯芬酸钠治疗骨性关节炎疗效对比[J]. 吉林医学, 2012, 33(6):1230.
12.	向成浩, 蒋从斌, 杨万波, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 华西医学, 2012, 27(12):1796-1799.
13.	王忠平. 盐酸氨基葡萄糖治疗骨关节炎的疗效评价[J]. 华西医学, 2013, 28(1):93-94.
14.	张绍龙. 盐酸氨基葡萄糖治疗膝骨关节炎的疗效观察[J]. 医药前沿, 2013(8):5.
15.	李敏, 杨南萍, 尉浩, 等. 双醋瑞因联合盐酸氨基葡萄糖、双氯芬酸钠治疗骨性关节炎疗效比较[J]. 华西医学, 2009, 24(8):2067-2069.
16.	高延军, 安久利, 赵广. 盐酸氨基葡萄糖联合洛索洛芬钠治疗膝骨性关节炎临床观察[J]. 中国骨肿瘤骨病, 2010, 9(3):248-251.
17.	曾伟南, 周宗科, 李海, 等. 氨基葡萄糖联合布洛芬与单用布洛芬治疗髋关节骨关节炎前瞻性随机对照临床研究[J]. 华西医学, 2012, 27(12):1805-1808.
18.	王燕. 氨基葡萄糖治疗骨关节炎疗效观察[J]. 基层医学论坛, 2012, 16(11):1417-1418.
19.	黎艳东. 塞来昔布联合盐酸氨基葡萄糖治疗膝骨性关节炎[J]. 中国医药导报, 2012, 9(21):87-88.
20.	闵华, 蒙珍. 双氯芬酸钠联合盐酸氨基葡萄糖治疗膝骨关节炎60例[J]. 中国药业, 2013, 22(9):31-32.
21.	丁国强. 盐酸氨基葡萄糖与对乙酰氨基酚治疗膝骨关节炎的临床疗效观察[J]. 华西医学, 2013, 28(12):1840-1842.
22.	James CB, Uhl TL. A review of articular cartilage pathology and the use of glucosamine sulfate[J]. J Athl Train, 2001, 36(4):413-419.
23.	Mujakperuo HR, Watson M, Morrison R, et al. Pharmacological interventions for pain in patients with temporomandibular disorders[J]. Cochrane Database Syst Rev, 2010(10):CD004715.
24.	Winickoff DE, Obasogie OK. Race-specific drugs:regulatory trends and public policy[J]. Trends Pharmacol Sci, 2008, 29(6):277-279.
25.	Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis:a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4):862-869.
26.	李春洁, 贾源源, 张绮, 等. 盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎的临床随机对照试验[J]. 华西口腔医学杂志, 2011, 29(6):632-635, 639.

1. Felson DT, Zhang Y. An update on the epidemiology of knee and hip osteoarthritis with a view to prevention[J]. Arthritis Rheum, 1998, 41(8):1343-1355.
2. 谢河秋. 盐酸氨基葡萄糖在膝骨性关节炎治疗中的临床观察[J]. 现代预防医学, 2009, 36(11):2161-2162.
3. Wu D, Huang Y, Gu Y, et al. Efficacies of different preparations of glucosamine for the treatment of osteoarthritis:a meta-analysis of randomised, double-blind, placebo-controlled trials[J]. Int J Clin Pract, 2013, 67(6):585-594.
4. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses[J]. BMJ, 2003, 327(7414):557-560.
5. 左川, 杨南萍, 陈咏涛. 硫酸氨基葡萄糖与双氯芬酸治疗膝骨关节炎的临床对照研究[J]. 中华风湿病学杂志, 2003, 7(5):306-308.
6. 张国华, 李桃. 盐酸氨基葡萄糖与双氯芬酸钠缓释片治疗骨性关节炎疗效对比[J]. 广东医学, 2006, 27(12):1907-1908.
7. 崔红霞, 王卫卫, 孟丽华. 盐酸氨基葡萄糖治疗骨关节炎的临床观察[J]. 中国实用医药, 2008, 3(34):163-164.
8. 赵延斌, 林伍伍. 盐酸氨基葡萄糖胶囊治疗膝骨关节炎疗效观察[J]. 中国药师, 2011, 14(9):1314-1315.
9. 吴建荣. 氨基葡萄糖对膝关节骨性关节炎临床疗效的平行对照研究[J]. 中国现代医生, 2011, 49(16):68-69.
10. 唐一仑, 王坤正, 党晓谦, 等. 盐酸氨基葡萄糖结合塞来昔布治疗膝骨关节炎的疗效观察[J]. 华西医学, 2012, 27(12):1780-1783.
11. 陈作桓. 盐酸氨基葡萄糖与双氯芬酸钠治疗骨性关节炎疗效对比[J]. 吉林医学, 2012, 33(6):1230.
12. 向成浩, 蒋从斌, 杨万波, 等. 盐酸氨基葡萄糖治疗膝骨关节炎的临床研究[J]. 华西医学, 2012, 27(12):1796-1799.
13. 王忠平. 盐酸氨基葡萄糖治疗骨关节炎的疗效评价[J]. 华西医学, 2013, 28(1):93-94.
14. 张绍龙. 盐酸氨基葡萄糖治疗膝骨关节炎的疗效观察[J]. 医药前沿, 2013(8):5.
15. 李敏, 杨南萍, 尉浩, 等. 双醋瑞因联合盐酸氨基葡萄糖、双氯芬酸钠治疗骨性关节炎疗效比较[J]. 华西医学, 2009, 24(8):2067-2069.
16. 高延军, 安久利, 赵广. 盐酸氨基葡萄糖联合洛索洛芬钠治疗膝骨性关节炎临床观察[J]. 中国骨肿瘤骨病, 2010, 9(3):248-251.
17. 曾伟南, 周宗科, 李海, 等. 氨基葡萄糖联合布洛芬与单用布洛芬治疗髋关节骨关节炎前瞻性随机对照临床研究[J]. 华西医学, 2012, 27(12):1805-1808.
18. 王燕. 氨基葡萄糖治疗骨关节炎疗效观察[J]. 基层医学论坛, 2012, 16(11):1417-1418.
19. 黎艳东. 塞来昔布联合盐酸氨基葡萄糖治疗膝骨性关节炎[J]. 中国医药导报, 2012, 9(21):87-88.
20. 闵华, 蒙珍. 双氯芬酸钠联合盐酸氨基葡萄糖治疗膝骨关节炎60例[J]. 中国药业, 2013, 22(9):31-32.
21. 丁国强. 盐酸氨基葡萄糖与对乙酰氨基酚治疗膝骨关节炎的临床疗效观察[J]. 华西医学, 2013, 28(12):1840-1842.
22. James CB, Uhl TL. A review of articular cartilage pathology and the use of glucosamine sulfate[J]. J Athl Train, 2001, 36(4):413-419.
23. Mujakperuo HR, Watson M, Morrison R, et al. Pharmacological interventions for pain in patients with temporomandibular disorders[J]. Cochrane Database Syst Rev, 2010(10):CD004715.
24. Winickoff DE, Obasogie OK. Race-specific drugs:regulatory trends and public policy[J]. Trends Pharmacol Sci, 2008, 29(6):277-279.
25. Kanzaki N, Saito K, Maeda A, et al. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis:a randomized, double-blind, placebo-controlled study[J]. J Sci Food Agric, 2012, 92(4):862-869.
26. 李春洁, 贾源源, 张绮, 等. 盐酸氨基葡萄糖片联合玻璃酸钠治疗颞下颌关节骨关节炎的临床随机对照试验[J]. 华西口腔医学杂志, 2011, 29(6):632-635, 639.

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