盐酸氨基葡萄糖治疗膝骨关节炎的临床效果分析_West China Medical Journal

Authors：

 李源力

川北医学院附属医院骨科（四川南充 637000）;

Corresponding author：

Keywords：

骨关节炎，膝; 盐酸氨基葡萄糖; 临床效果

DOI：

10.7507/1002-0179.201600328

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目的观察盐酸氨基葡萄糖治疗膝骨关节炎的临床疗效。方法选取2014年8月－2015年6月收治的98例膝骨关节炎患者，给予口服盐酸氨基葡萄糖（疗程为3个月，随访至治疗后第6个月），治疗结束后根据Lysholm膝关节评分，比较治疗前后的效果。结果 98例患者均服用盐酸氨基葡萄糖，治疗前Lysholm膝关节评分的优良率为35.71%，治疗后第1、2、3及6个月时分别为46.94%、54.08%、61.22%、73.47%，治疗后第3、6个月较治疗前有显著改善，差异有统计学意义（P＜0.05）。结论盐酸氨基葡萄糖对膝骨关节炎的治疗疗效好，能够改善膝骨关节炎的症状。

Citation： 李源力. 盐酸氨基葡萄糖治疗膝骨关节炎的临床效果分析. West China Medical Journal, 2016, 31(7): 1203-1204. doi: 10.7507/1002-0179.201600328 Copy

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1. Glyn-Jones S, Palmer AJ, Agricola R, et al. Osteoarthritis[J]. Lancet, 2015, 386(9991):376-387.
2. Kampen WU, Tillmann B. Age-related changes in the articular cartilage of human sacroiliac joint[J]. Anat Embryol (Berl), 1998, 198(6):505-513.
3. 崔玉明, 伍骥, 胡蕴玉. 聚乳酸/聚羟基乙酸复合骨形成蛋白修复兔关节软骨缺损[J]. 中国修复重建外科杂志, 2007, 21(11):1233-1237.
4. 徐建强, 杨庆铭, 邓廉夫, 等. 诱导后自体骨髓基质细胞移植修复兔关节软骨缺损[J]. 中华骨科杂志, 2001, 21(3):179-183.
5. Hom DB, Linzie BM, Huang TC. The healing effects of autologous platelet gel on acute human skin wounds[J]. Arch Facial Plast Surg, 2007, 9(3):174-183.
6. Marx RE, Carlson ER, Eichstaedt RM, et al. Platelet-rich plasma:growth factor enhancement for bone grafts[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998, 85(6):638-646.
7. Klagsbrum M. Large-scale preparation of chondrocytes[J]. Methods Enzymol, 1979, 58(8):560.
8. Hubbard MJ. Articular debridement versus washout for degeneration of the medial femoral condyle. A five-year study[J]. J Bone Joint Surg Br, 1996, 78(2):217-219.
9. Steadman JR, Briggs KK, Rodrigo JJ, et al. Outcomes of microfracture for traumatic chondral defects of the knee:average 11-year follow-up[J]. Arthroscopy, 2003, 19(5):477-484.
10. Hangody L, Füles P. Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints:ten years of experimental and clinical experience[J]. J Bone Joint Surg Am, 2003, 85(Suppl 2):25-32.
11. Henderson I, Tuy B, Oakes B. Reoperation after autologous chondrocyte implantation. Indications and findings[J]. J Bone Joint Surg Br, 2004, 86(2):205-211.
12. Bassleer C, Jy R, Franchimont P. Effects of glucosamine on differentiated human chondrocytes cultivated in clusters[J]. Clin Rheumatol, 1992, 11(1):60-65.
13. Fox BA, Schmitz ED, Wallace R. FPIN's clinical inquiries. Glucosamine and chondroitin for osteoarthritis[J]. Am Fam Physician, 2006, 73(7):1245-1246.
14. Ted AY, Tsukimura N. A six-month followup of a randomized trial comparing the efficacy of a latera1-wedge insole with subtalar strapping and an in-shoe lateral-wedge insole in patients with varus deformity osteoarthritis of the knee[J]. Arthritis Rheum, 2004, 50(10):3129-3136.
15. Wandel S, Jüni P, Tendal B, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee:network metaanalysis[J]. BMJ, 2010, 341:c4675.

West China Medical Journal

盐酸氨基葡萄糖治疗膝骨关节炎的临床效果分析

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