A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease_West China Medical Journal

Authors：

 HE Suyu , LIU Yijun , CHEN Yongjun , TANG Yi , XU Jianyu , WU Yan

Department of Gastroenterology, Suining Central Hospital, Suining, Sichuan 629000, P. R. China;

Corresponding author：

HE Suyu, Email: hesuyu2009@163.com

Keywords：

Type 2 diabetes mellitus; Gastroesophageal reflux disease; Gastrin

DOI：

10.7507/1002-0179.201601117

Video：

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Objective To investigate the gastrin level in patients with type 2 diabetes mellitus (T2DM) with gastroesophageal reflux disease (GERD), and analyze the possible mechanism of gastrin in the pathogenesis of T2DM combined with GERD. Methods Thirty-eight patients with T2DM combined with GERD treated between January 2013 and January 2015 were designated as group A; 40 patients with T2DM only were regarded as group B; 36 patients with GERD only were regarded as group C; and another 40 healthy volunteers who underwent physical examination at the same period were regarded as group D. The fasting serum levels of gastrin were measured and compared among the above four groups. Results The fasting serum level of gastrin was significantly higher in group A [(116.53±22.02) pg/mL] than group B [(101.89±20.76) pg/mL], group C [(90.04±21.16) pg/mL], and group D [(92.48±19.69) pg/mL] (P<0.01). The fasting serum level of gastrin in group B was significantly higher than group C and D (P<0.05). There was no significant difference between group C and D in terms of fasting serum level of gastrin (P>0.05). Conclusions There is a high level of gastrin in patients with GERD combined with T2DM. Abnormal secretion of gastrin may be closely related with the occurrence and development of T2DM and GERD.

Citation： HE Suyu, LIU Yijun, CHEN Yongjun, TANG Yi, XU Jianyu, WU Yan. A study on the level of gastrin in patients with type 2 diabetes mellitus and gastroesophageal reflux disease. West China Medical Journal, 2017, 32(3): 383-386. doi: 10.7507/1002-0179.201601117 Copy

1.	Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 2010, 87(1): 4-14.
2.	Moayyedi P, Talley NJ. Gastro-esophageal reflux disease. Lancet, 2006, 367(9528): 2086-2100.
3.	Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol, 2006, 4(4): 398-407.
4.	Wang X, Pitchumoni CS, Chandrarana K,et al. Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol, 2008, 14(5): 709-712.
5.	Hirata A, Kishida K, Nakatsuji H,et al. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutr Metab (Lond), 2012, 9(1): 4.
6.	朱瑞平, 邓长生, 朱尤庆. 老年 2 型糖尿病患者胃液体排空与胃泌素、胃动素、生长抑素的关系. 武汉大学学报: 医学版, 2003, 24(3): 268-270.
7.	吴祖荣, 韦玲, 陈宗存, 等. 血浆P物质和血管活性肠肽在糖尿病伴胃食管反流病中表达及意义. 世界华人消化杂志, 2015, 23(27): 4447-4451.
8.	王连芬, 郑长青, 林连捷, 等. GERDQ 量表在胃食管反流病中的诊断价值. 世界华人消化杂志, 2011, 19(18): 1941-1945.
9.	Natalini J, Palit A, Sankineni A,et al. Diabetes mellitus is an Independent risk for gastroesophageal reflux disease among urban African Americans. Dis Esophagus, 2015, 28(5): 405-411.
10.	张宏伟, 师永芳. 胃食管反流病与代谢综合征及其组分的相关性研究. 中国医师杂志, 2013, 15(6): 785-788.
11.	王丽红, 仇日火. 老年糖尿病患者食管下括约肌压力水平测定. 中国老年学杂志, 2012, 32(19): 4299-4300.
12.	向旭. 胃肠激素与糖尿病并发胃食管反流病. 胃肠病学和肝病学杂志, 2013, 22(8): 823-825.
13.	牛奔, 苏恒, 李超, 等. 2 型糖尿病外周感觉神经病变和心自主神经病变关系的研究. 中国糖尿病杂志, 2013, 21(2): 139-141.
14.	张绍刚, 程留芳, 白梅, 等. 2 型糖尿病胃轻瘫患者胃肠激素水平的测定. 中国综合临床, 2002, 18(5): 433-434.
15.	Horikawa A, Ishii-Nozawa R, Ohguro M,et al. Prevalence of GERD in type 2 diabetes and a comparison of clinical profiles between diabetic patients with and without GERD. Diabet Med, 2009, 26(3): 228-233.
16.	冯桂建, 胡伏莲, 王化虹, 等. 幽门螺杆菌和胃泌素与胃食管反流病的关系. 中华医学杂志, 2003, 83(2): 96-99.
17.	Kwon JH, Chung IS, Son HS,et al. The relationship of gastrin, pepsinogen, and Helicobacter pylori in erosive reflux esophagitis. Korean J Gastroenterol, 2008, 51(3): 159-166.
18.	Yakut M, Kabacam G, Bektaş M,et al. The effect of endogenous hypergastrinemia on lower esophageal sphincter pressure and esophageal motility. Hepatogastroenterology, 2012, 58(112): 1989-1992.
19.	刘玉成, 李玉, 解晨昊, 等. 胃泌素对胃食管反流病患者食管压力及 pH 的影响. 河北医科大学学报, 2002, 23(6): 327-329.
20.	Straathof JW, Lamers CB, Masclee AA. Effect of gastrin-17 on lower esophageal sphincter characteristics in man. Dig Dis Sci, 1997, 42(12): 2547-2551.

1. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract, 2010, 87(1): 4-14.
2. Moayyedi P, Talley NJ. Gastro-esophageal reflux disease. Lancet, 2006, 367(9528): 2086-2100.
3. Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol, 2006, 4(4): 398-407.
4. Wang X, Pitchumoni CS, Chandrarana K,et al. Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol, 2008, 14(5): 709-712.
5. Hirata A, Kishida K, Nakatsuji H,et al. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutr Metab (Lond), 2012, 9(1): 4.
6. 朱瑞平, 邓长生, 朱尤庆. 老年 2 型糖尿病患者胃液体排空与胃泌素、胃动素、生长抑素的关系. 武汉大学学报: 医学版, 2003, 24(3): 268-270.
7. 吴祖荣, 韦玲, 陈宗存, 等. 血浆P物质和血管活性肠肽在糖尿病伴胃食管反流病中表达及意义. 世界华人消化杂志, 2015, 23(27): 4447-4451.
8. 王连芬, 郑长青, 林连捷, 等. GERDQ 量表在胃食管反流病中的诊断价值. 世界华人消化杂志, 2011, 19(18): 1941-1945.
9. Natalini J, Palit A, Sankineni A,et al. Diabetes mellitus is an Independent risk for gastroesophageal reflux disease among urban African Americans. Dis Esophagus, 2015, 28(5): 405-411.
10. 张宏伟, 师永芳. 胃食管反流病与代谢综合征及其组分的相关性研究. 中国医师杂志, 2013, 15(6): 785-788.
11. 王丽红, 仇日火. 老年糖尿病患者食管下括约肌压力水平测定. 中国老年学杂志, 2012, 32(19): 4299-4300.
12. 向旭. 胃肠激素与糖尿病并发胃食管反流病. 胃肠病学和肝病学杂志, 2013, 22(8): 823-825.
13. 牛奔, 苏恒, 李超, 等. 2 型糖尿病外周感觉神经病变和心自主神经病变关系的研究. 中国糖尿病杂志, 2013, 21(2): 139-141.
14. 张绍刚, 程留芳, 白梅, 等. 2 型糖尿病胃轻瘫患者胃肠激素水平的测定. 中国综合临床, 2002, 18(5): 433-434.
15. Horikawa A, Ishii-Nozawa R, Ohguro M,et al. Prevalence of GERD in type 2 diabetes and a comparison of clinical profiles between diabetic patients with and without GERD. Diabet Med, 2009, 26(3): 228-233.
16. 冯桂建, 胡伏莲, 王化虹, 等. 幽门螺杆菌和胃泌素与胃食管反流病的关系. 中华医学杂志, 2003, 83(2): 96-99.
17. Kwon JH, Chung IS, Son HS,et al. The relationship of gastrin, pepsinogen, and Helicobacter pylori in erosive reflux esophagitis. Korean J Gastroenterol, 2008, 51(3): 159-166.
18. Yakut M, Kabacam G, Bektaş M,et al. The effect of endogenous hypergastrinemia on lower esophageal sphincter pressure and esophageal motility. Hepatogastroenterology, 2012, 58(112): 1989-1992.
19. 刘玉成, 李玉, 解晨昊, 等. 胃泌素对胃食管反流病患者食管压力及 pH 的影响. 河北医科大学学报, 2002, 23(6): 327-329.
20. Straathof JW, Lamers CB, Masclee AA. Effect of gastrin-17 on lower esophageal sphincter characteristics in man. Dig Dis Sci, 1997, 42(12): 2547-2551.

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