Preliminary research on long-term growth condition of 180 offspring of pregnant women with gestational diabetes mellitus_West China Medical Journal

Authors：

SONG Weifu ,  WANG Ruihua , FENG Min , YANG Na

Department of Obstetrics and Gynecology, Woman & Child Care Center of Qinhuangdao City, Qinhuangdao, Hebei 066000, P. R. China;

Corresponding author：

WANG Ruihua, Email: 552351196@qq.com

Keywords：

Gestational diabetes mellitus; Long-term growth of offspring; Maternal and infantile outcomes

DOI：

10.7507/1002-0179.201605037

Video：

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Objective To guide blood glucose management during pregnancy and reduce the incidence of long-term complications of the fetus by exploring the long-term growth condition of offspring of pregnant women with gestational diabetes mellitus. Methods A total of 180 cases full-term newborns of pregnant women with gestational diabetes mellitus from December 25th, 2011 to December 25th, 2012 were selected as the diabetes group. Another 200 newborns of pregnant women without any complications were randomly collected as the control group. Birth weight, gestational age, sex, blood glucose, and 24-, 48-, 72- and 120-hour transcutaneous bilirubin value after the birth of the newborns were recorded; weight, height, body mass index (BMI), triglycerides, total cholesterol, high density lipoprotein (HDL), low density lipoprotein, blood pressure and fasting plasma glucose quota between the two groups were contrasted when the children were three years old. Results There were no significant difference in the birth weight, gestational age and sex between the diabetic and the control group. The blood glucose levels of the newborns in the diabetic group was significantly lower than that in the control group (P<0.05). The 24-, 48-, 72- and 120-hour transcutaneous bilirubin values of the newborns in the diabetic group were significantly higher than those of the control group (P<0.05). The weight, height and BMI of the three years old offspring in the diabetic group were significantly higher than those in the control group (P<0.05). There were no significant difference in triglycerides, total cholesterol, HDL, Low density lipoprotein, fasting plasma glucose quota, and systolic blood pressure between the diabetic group and the control group (P>0.05), but the diastolic blood pressure in the diabetic group was much higher than that in the control group (P<0.05). Conclusion The impact of gestational diabetes mellitus on offspring of pregnant women was not only in the fetus and newborn period, but also in the future, which should be timely intervened.

Citation： SONG Weifu, WANG Ruihua, FENG Min, YANG Na. Preliminary research on long-term growth condition of 180 offspring of pregnant women with gestational diabetes mellitus. West China Medical Journal, 2017, 32(7): 1006-1010. doi: 10.7507/1002-0179.201605037 Copy

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11.	Tam WH, Ma RC, Yang X, et al. Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero. Pediatrics, 2008, 122(6): 1229-1234.
12.	Tam WH, Ma RC, Yang X, et al. Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study. Diabetes Care, 2010, 33(6): 1382-1384.
13.	Malcolm JC, Lawson ML, Gaboury I, et al. Glucose tolerance of offspring of mother with gestational diabetes mellitus in a low-risk population. Diabet Med, 2006, 23(5): 565-570.
14.	李海华, 吕智海, 郭岚敏. 高胆红素血症致脑性瘫痪 15 例. 实用儿科临床杂志, 2006, 21(10): 637.

1. 谢幸, 苟文丽. 妇产科学. 8 版. 北京: 人民卫生出版社, 2013: 77.
2. 曹泽毅. 中华妇产科学(临床版). 北京: 人民卫生出版社, 2012: 63.
3. 张丽, 段涛, 杨慧霞. 健康与疾病的发生起源国际研讨会纪要. 中华妇产科杂志, 2010, 45(9): 644-645.
4. 杨慧霞, 马京梅. 健康与疾病的发育起源对围产医学实践的启迪. 中华围产医学杂志, 2010, 13(6): 441-443.
5. 王晨, 杨慧霞. 妊娠合并糖尿病对子代的远期影响. 中华妇产科杂志, 2014, 49(2): 143-146.
6. 李璟, 严学勤, 高建慧, 等. 母亲妊娠期糖尿病的婴儿生长发育调查分析. 临床医学, 2011, 31(7): 86-87.
7. Vohr BR, Mcgarvey ST, Tucker R. Effects of maternal gestational diabetes on offspring adiposity at 4-7 years of age. Diabetes Care, 1999, 22(8): 1284-1291.
8. Schaefer-Graf UM, Pawliczak J, Passow D, et al. Birth weight and parental BMI predict overweight in children from mothers with gestational diabetes. Diabetes Care, 2005, 28(7): 1745-1750.
9. Wright CS, Rifas-Shiman SL, Rich-Edwards JW, et al. Intrauterine exposure to gestational diabetes, child adiposity, and blood pressure. Am J Hypertens, 2009, 22(2): 215-220.
10. Tsadok MA, Friedlander Y, Paltiel O, et al. Obesity and blood pressure in 17-year-old offspring of mothers with gestational diabetes: insights from the Jeruslem Perinatal Study. Experimental diabetents research, 2011: 1-6.
11. Tam WH, Ma RC, Yang X, et al. Glucose intolerance and cardiometabolic risk in children exposed to maternal gestational diabetes mellitus in utero. Pediatrics, 2008, 122(6): 1229-1234.
12. Tam WH, Ma RC, Yang X, et al. Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study. Diabetes Care, 2010, 33(6): 1382-1384.
13. Malcolm JC, Lawson ML, Gaboury I, et al. Glucose tolerance of offspring of mother with gestational diabetes mellitus in a low-risk population. Diabet Med, 2006, 23(5): 565-570.
14. 李海华, 吕智海, 郭岚敏. 高胆红素血症致脑性瘫痪 15 例. 实用儿科临床杂志, 2006, 21(10): 637.

West China Medical Journal

Preliminary research on long-term growth condition of 180 offspring of pregnant women with gestational diabetes mellitus

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