Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children_West China Medical Journal

Authors：

DU Jiyu ,  LIU Rong , LI Yan , WANG Xiaoshuang , YANG Jinyu , XIE Li

Department of Paediatrics, Mianyang Central Hospital, Mianyang, Sichuan 621000, P. R. China;

Corresponding author：

LIU Rong, Email: 734287795@qq.com

Keywords：

Childhood asthma; Inducing factor; Serum total immunoglobulin E; Serum specific immunoglobulin E

DOI：

10.7507/1002-0179.201605043

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To explore the inducing factors, the serum total immunoglobulin E (IgE) and specific IgE of bronchial asthma in Mianyang children, for better control of childhood asthma. Methods A total of 1 288 cases of asthma who were hospitalized in pediatric respiratory ward or asthma clinic from March 2013 to February 2016 were enrolled in the study. All cases complied with the diagnostic criteria for acute episode of childhood bronchial asthma revised in 2008 by the National Children’s Asthma Cooperative Group. The causes of asthma attack were asked by doctors, and the patient’s serum total IgE and specific IgE was tested. Results Respiratory tract infections were the most common cause (1 057 cases, 82.1%), which was followed by weather changes and exposure to cold air (694 cases, 53.9%), and then food (304, 23.6%). The risk of asthma induced by respiratory infections was highest in <2-year old group (358 cases, 97.5%), and lowest in 10-14-year old group (42 cases, 33.3%), with a decreasing trend with age (χ²_trend=239.865, P<0.001). Food was also an important inducing factor, and seafood was the most frequent (121 cases, 39.8%). Total serum IgE was positive in 868 cases (67.4%). The positive rate in <2-year old group (52.6%) was the lowest, and the positive rate in 10-14-year old group (89.7%) was the highest, with an increasing trend with age (χ²_trend=88.055, P<0.001). Serum specific IgE was positive in 733 cases (56.9%). The positive rate in <2-year old group (37.1%) was the lowest, and the positive rate in 10-14-year old group (92.6%) was the highest, with an increasing trend with age (χ²_trend=150.361, P<0.001). The progressive rate of dust mites in inhalation and dietary allergens was highest (668 cases, 51.8%), which was followed by house dust (431 cases, 33.4%). Conclusions The most common inducing factor for bronchial asthma in Mianyang children is respiratory tract infection, followed by the weather changes and cold air exposure, and then food. Detection of serum total IgE and specific IgE is more valuable in elderly children with bronchial asthma.

Citation： DU Jiyu, LIU Rong, LI Yan, WANG Xiaoshuang, YANG Jinyu, XIE Li. Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children. West China Medical Journal, 2017, 32(7): 1029-1032. doi: 10.7507/1002-0179.201605043 Copy

1.	全国儿童哮喘协作组. 第三次中国城市儿童哮喘流行病学调查. 中华儿科杂志, 2013, 51(10): 729-735.
2.	中华医学会儿科分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南. 中华儿科杂志, 2008, 46(10): 745-753.
3.	全国儿科哮喘防治协作组. 全国 90 万 0-14 岁儿童支气管哮喘患病情况调查. 中华结核呼吸杂志, 1993, 16(增刊1): 64-68.
4.	全国儿科哮喘防治协作组. 中国城区儿童哮喘患病率调查. 中华儿科杂志, 2003, 41(20): 123-127.
5.	Papadopoulos NG, Arakawa H, Carlsen KH, et al. 儿童哮喘国际共识. 中华实用儿科临床杂志, 2014, 29(1): 67-76.
6.	中国哮喘儿童家长知信行调查项目组. 中国大陆 29 城市哮喘患儿病情控制状况及影响因素. 中华儿科杂志, 2013, 51(2): 90-95.
7.	Wong G, Kwon N, Hong JG, et al. Pediatric asthma control in Asia: Phase 2 of the Asthma Insights and Reality in Asia-Pacific (AIRIAP 2) survey. Allergy, 2013, 68(4): 524-530.
8.	Papadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma. Allergy, 2012, 67(8): 976-997.
9.	Singer F, Luchsinger I, Inci D, et al. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma. Allergy, 2013, 68(4): 531-538.
10.	郑跃杰, 刘萍, 袁雄伟, 等. 总免疫球蛋白 E 和特异性免疫球蛋白 E 在儿童呼吸道变态反应性疾病中的分布. 实用儿科临床杂志, 2006, 21(21): 1455-1456.
11.	王静, 付亚南, 王群, 等. 总免疫球蛋白 E 和特异性免疫球蛋白 E 在儿童呼吸道变态反应性疾病中的分布. 中华实用儿科临床杂志, 2014, 29(4): 289-294.
12.	陈宇明, 黄东明, 肖晓雄, 等. 皮肤和血清过敏原检测对儿童支气管哮喘的意义. 第三军医大学学报, 2010, 32(13): 1477-1478.
13.	赵凯, 徐红梅, 叶侃. 苏州地区支气管哮喘儿童特异性过敏原检查的意义. 中华实用儿科临床杂志, 2007, 22(4): 279-280.
14.	杭金国, 姚泽忠, 管敏昌, 等. 台州地区支气管哮喘患儿过敏原特异性 IgE 检查分析及临床意义. 检验医学, 2011, 26(9): 627.
15.	武其文, 蔡鹏程, 陈治中, 等. 武汉地区支气管哮喘患儿过敏原特异性 IgE 分析. 临床血液学杂志, 2009, 22(1): 65-67.
16.	吴艳, 范晓东, 惠复新, 等. 江苏无锡地区支气管哮喘患者过敏原特异性 IgE 分析. 实用临床医药杂志, 2010, 14(15): 119-121.
17.	蔡幸生, 林丽爱, 黄育涛, 等. 儿童支气管哮喘 112 例过敏原分析. 广东医学, 2016, 37(9): 1360-1361.

1. 全国儿童哮喘协作组. 第三次中国城市儿童哮喘流行病学调查. 中华儿科杂志, 2013, 51(10): 729-735.
2. 中华医学会儿科分会呼吸学组, 《中华儿科杂志》编辑委员会. 儿童支气管哮喘诊断与防治指南. 中华儿科杂志, 2008, 46(10): 745-753.
3. 全国儿科哮喘防治协作组. 全国 90 万 0-14 岁儿童支气管哮喘患病情况调查. 中华结核呼吸杂志, 1993, 16(增刊1): 64-68.
4. 全国儿科哮喘防治协作组. 中国城区儿童哮喘患病率调查. 中华儿科杂志, 2003, 41(20): 123-127.
5. Papadopoulos NG, Arakawa H, Carlsen KH, et al. 儿童哮喘国际共识. 中华实用儿科临床杂志, 2014, 29(1): 67-76.
6. 中国哮喘儿童家长知信行调查项目组. 中国大陆 29 城市哮喘患儿病情控制状况及影响因素. 中华儿科杂志, 2013, 51(2): 90-95.
7. Wong G, Kwon N, Hong JG, et al. Pediatric asthma control in Asia: Phase 2 of the Asthma Insights and Reality in Asia-Pacific (AIRIAP 2) survey. Allergy, 2013, 68(4): 524-530.
8. Papadopoulos NG, Arakawa H, Carlsen KH, et al. International consensus on (ICON) pediatric asthma. Allergy, 2012, 67(8): 976-997.
9. Singer F, Luchsinger I, Inci D, et al. Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma. Allergy, 2013, 68(4): 531-538.
10. 郑跃杰, 刘萍, 袁雄伟, 等. 总免疫球蛋白 E 和特异性免疫球蛋白 E 在儿童呼吸道变态反应性疾病中的分布. 实用儿科临床杂志, 2006, 21(21): 1455-1456.
11. 王静, 付亚南, 王群, 等. 总免疫球蛋白 E 和特异性免疫球蛋白 E 在儿童呼吸道变态反应性疾病中的分布. 中华实用儿科临床杂志, 2014, 29(4): 289-294.
12. 陈宇明, 黄东明, 肖晓雄, 等. 皮肤和血清过敏原检测对儿童支气管哮喘的意义. 第三军医大学学报, 2010, 32(13): 1477-1478.
13. 赵凯, 徐红梅, 叶侃. 苏州地区支气管哮喘儿童特异性过敏原检查的意义. 中华实用儿科临床杂志, 2007, 22(4): 279-280.
14. 杭金国, 姚泽忠, 管敏昌, 等. 台州地区支气管哮喘患儿过敏原特异性 IgE 检查分析及临床意义. 检验医学, 2011, 26(9): 627.
15. 武其文, 蔡鹏程, 陈治中, 等. 武汉地区支气管哮喘患儿过敏原特异性 IgE 分析. 临床血液学杂志, 2009, 22(1): 65-67.
16. 吴艳, 范晓东, 惠复新, 等. 江苏无锡地区支气管哮喘患者过敏原特异性 IgE 分析. 实用临床医药杂志, 2010, 14(15): 119-121.
17. 蔡幸生, 林丽爱, 黄育涛, 等. 儿童支气管哮喘 112 例过敏原分析. 广东医学, 2016, 37(9): 1360-1361.

West China Medical Journal

Analysis of the inducing factors, the serum total immunoglobulin E and specific immunoglobulin E of bronchial asthma in Mianyang children

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content