辅助生殖技术与子代神经系统疾病的相关性研究回顾_West China Medical Journal

Authors：

程萌 ¹ , 陈晗笑 ² , 许佳文 ² ,  秦朗 ¹

1. ;
2. ;

Corresponding author：

秦朗, Email: cacier@126.com

Keywords：

辅助生殖技术; 体外受精-胚胎移植; 卵胞浆内单精子显微注射; 种植前遗传学诊断; 神经系统疾病

DOI：

10.7507/1002-0179.201703192

Video：

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辅助生殖技术是目前治疗不孕症的主要手段之一。由于辅助生殖技术涉及对卵泡发育、精卵结合、胚胎形成、转运、种植过程的人为干预，自 1978 年首例试管婴儿诞生以来，其安全性，尤其是对子代健康的影响一直受到人们的关注。神经系统疾病是常见的出生缺陷之一。由于神经系统疾病通常影响儿童的精神、情绪、智力、运动、语言等关键能力，且神经系统的损伤往往不可修复，因此婴幼儿一旦罹患神经系统疾病对家庭和社会来说无疑是巨大的打击与负担。该文就辅助生殖技术与几种常见的子代神经系统疾病如智力低下、脑瘫、癫痫的关系进行了综述，并对辅助生殖技术对子代神经系统的安全性进行评价，从而进一步指导临床不孕症的治疗及围产期的母儿监护。

Citation： 程萌, 陈晗笑, 许佳文, 秦朗. 辅助生殖技术与子代神经系统疾病的相关性研究回顾. West China Medical Journal, 2017, 32(5): 679-683. doi: 10.7507/1002-0179.201703192 Copy

1.	Zhan QT, Pan PP, Xu XR, et al. An overview of studies on psychological well-being in children born following assisted reproductive technologies. J Zhejiang Univ Sci B, 2013, 14(11): 947-960.
2.	高雅. 人类辅助生殖技术对子代出生缺陷影响的系统评价. 重庆: 重庆医科大学, 2013.
3.	Hyrapetian M, Loucaides EM, Sutcliffe AG. Health and disease in children born after assistive reproductive therapies (art). J Reprod Immunol, 2014, 106: 21-26.
4.	Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. PartⅡ--Mental health and development outcomes. Hum Reprod Update, 2013, 19(3): 244-250.
5.	陈小琴, 张清学, 李予, 等. 266 例辅助生殖技术出生 1～3 岁儿童体格和精神运动发育状况分析. 国际生殖健康/计划生育杂志, 2014, 33(2): 113-116.
6.	郑思锐. 人工助孕子代的体格和神经精神发育状况的临床研究. 福州: 福建医科大学, 2013.
7.	Place I, Englert Y. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and byin vitro fertiliza. Fertil Steril, 2003, 80(6): 1388-1397.
8.	Pinborg A, Loft A, Schmidt L, et al. Neurological sequelae in twins born after assisted conception: controlled National cohort study. BMJ, 2004, 329(7461): 311.
9.	Banerjee I, Shevlin M, Taranissi M, et al. Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study. Reprod Biomed Online, 2008, 16(3): 376-381.
10.	Winter C, Van Acker F, Bonduelle M, et al. Cognitive and psychomotor development of 5- to 6-year-old singletons born after PGD: a prospective case-controlled matched study. Hum Reprod, 2014, 29(9): 1968-1977.
11.	Goldbeck L, Gagsteiger F, Mindermann I, et al. Cognitive development of singletons conceived by intracytoplasmic sperm injection orin vitro fertilization at age 5 and 10 years. J Pediatr Psychol, 2009, 34(7): 774-781.
12.	Knoester M, Helmerhorst FM, Vandenbroucke JP, et al. Cognitive development of singletons born after intracytoplasmic sperm injection compared within vitro fertilization and natural conception. Fertil Steril, 2008, 90(2): 289-296.
13.	Bellieni C, Buonocore G. Assisted procreation: too little consideration for the babies?. Ethic Med, 2006, 22(2): 93-98.
14.	Pinborg A, Loft A, Schmidt L, et al. Neurological late sequelae in twins born afterin vitro fertilisation--secondary publication. A national cohort study. Ugeskr laeger, 2005, 167(33): 3051-3054.
15.	Källén B, Finnström O, Nygren KG, et al.In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril, 2005, 84(3): 605-610.
16.	Finnström O, Källén B, Lindam A, et al. Maternal and child outcome afterin vitro fertilization--a review of 25 years of population-based data from Sweden. Acta Obstet Gynecol Scand, 2011, 90(5): 494-500.
17.	Klemetti R, Sevón T, Gissler M, et al. Health of children born as a result ofin vitro fertilization. Pediatrics, 2006, 118(5): 1819-1827.
18.	Strömberg B, Dahlquist G, Ericson A, et al. Neurological sequelae in children born afterin-vitro fertilisation: a population-based study. Lancet, 2002, 359(935): 461-465.
19.	D’Souza SW, Rivlin E, Cadman J, et al. Children conceived byin vitro fertilisation after fresh embryo transfer. Arch Dis Child Fetal Neonatal Ed, 1997, 76(2): F70-F74.
20.	Ramoğlu M, Kavuncuoğlu S, Aldemir E, et al. Neurodevelopment of preterm infants born afterin vitro fertilization and spontaneous multiple pregnancy. Pediatr Int, 2016, 58(12): 1284-1290.
21.	Abdel-Latif ME, Bajuk B, Ward M, et al. Neurodevelopmental outcomes of extremely premature infants conceived after assisted conception: a population based cohort study. Arch Dis Child Fetal Neonatal Ed, 2013, 98(3): F205-F211.
22.	Yu VY. Assisted reproduction technology, multiple births, and adverse perinatal outcome. Croat Med J, 1998, 39(2): 208-211.
23.	Kettner LO, Ramlau-Hansen CH, Kesmodel US, et al. Parental infertility, fertility treatment, and childhood epilepsy: a population-based cohort study. Paediatr Perinat Epidemiol, 2016, 30(5): 488-495.
24.	Sun Y, Vestergaard M, Christensen J, et al. Epilepsy and febrile seizures in children of treated and untreated subfertile couples. Hum Reprod, 2007, 22(1): 215-220.
25.	Ericson A, Nygren KG, Olausson PO, et al. Hospital care utilization of infants born after IVF. Hum Reprod, 2002, 17(4): 929-932.
26.	殷林亮. 辅助生殖技术受孕胎儿颅内结构发育的产前超声研究. 苏州: 苏州大学, 2013.
27.	陈丹. 辅助生殖技术受孕新生儿疾病特点及 6 月龄神经发育预后的研究. 郑州: 郑州大学, 2013.

1. Zhan QT, Pan PP, Xu XR, et al. An overview of studies on psychological well-being in children born following assisted reproductive technologies. J Zhejiang Univ Sci B, 2013, 14(11): 947-960.
2. 高雅. 人类辅助生殖技术对子代出生缺陷影响的系统评价. 重庆: 重庆医科大学, 2013.
3. Hyrapetian M, Loucaides EM, Sutcliffe AG. Health and disease in children born after assistive reproductive therapies (art). J Reprod Immunol, 2014, 106: 21-26.
4. Hart R, Norman RJ. The longer-term health outcomes for children born as a result of IVF treatment. PartⅡ--Mental health and development outcomes. Hum Reprod Update, 2013, 19(3): 244-250.
5. 陈小琴, 张清学, 李予, 等. 266 例辅助生殖技术出生 1～3 岁儿童体格和精神运动发育状况分析. 国际生殖健康/计划生育杂志, 2014, 33(2): 113-116.
6. 郑思锐. 人工助孕子代的体格和神经精神发育状况的临床研究. 福州: 福建医科大学, 2013.
7. Place I, Englert Y. A prospective longitudinal study of the physical, psychomotor, and intellectual development of singleton children up to 5 years who were conceived by intracytoplasmic sperm injection compared with children conceived spontaneously and byin vitro fertiliza. Fertil Steril, 2003, 80(6): 1388-1397.
8. Pinborg A, Loft A, Schmidt L, et al. Neurological sequelae in twins born after assisted conception: controlled National cohort study. BMJ, 2004, 329(7461): 311.
9. Banerjee I, Shevlin M, Taranissi M, et al. Health of children conceived after preimplantation genetic diagnosis: a preliminary outcome study. Reprod Biomed Online, 2008, 16(3): 376-381.
10. Winter C, Van Acker F, Bonduelle M, et al. Cognitive and psychomotor development of 5- to 6-year-old singletons born after PGD: a prospective case-controlled matched study. Hum Reprod, 2014, 29(9): 1968-1977.
11. Goldbeck L, Gagsteiger F, Mindermann I, et al. Cognitive development of singletons conceived by intracytoplasmic sperm injection orin vitro fertilization at age 5 and 10 years. J Pediatr Psychol, 2009, 34(7): 774-781.
12. Knoester M, Helmerhorst FM, Vandenbroucke JP, et al. Cognitive development of singletons born after intracytoplasmic sperm injection compared within vitro fertilization and natural conception. Fertil Steril, 2008, 90(2): 289-296.
13. Bellieni C, Buonocore G. Assisted procreation: too little consideration for the babies?. Ethic Med, 2006, 22(2): 93-98.
14. Pinborg A, Loft A, Schmidt L, et al. Neurological late sequelae in twins born afterin vitro fertilisation--secondary publication. A national cohort study. Ugeskr laeger, 2005, 167(33): 3051-3054.
15. Källén B, Finnström O, Nygren KG, et al.In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril, 2005, 84(3): 605-610.
16. Finnström O, Källén B, Lindam A, et al. Maternal and child outcome afterin vitro fertilization--a review of 25 years of population-based data from Sweden. Acta Obstet Gynecol Scand, 2011, 90(5): 494-500.
17. Klemetti R, Sevón T, Gissler M, et al. Health of children born as a result ofin vitro fertilization. Pediatrics, 2006, 118(5): 1819-1827.
18. Strömberg B, Dahlquist G, Ericson A, et al. Neurological sequelae in children born afterin-vitro fertilisation: a population-based study. Lancet, 2002, 359(935): 461-465.
19. D’Souza SW, Rivlin E, Cadman J, et al. Children conceived byin vitro fertilisation after fresh embryo transfer. Arch Dis Child Fetal Neonatal Ed, 1997, 76(2): F70-F74.
20. Ramoğlu M, Kavuncuoğlu S, Aldemir E, et al. Neurodevelopment of preterm infants born afterin vitro fertilization and spontaneous multiple pregnancy. Pediatr Int, 2016, 58(12): 1284-1290.
21. Abdel-Latif ME, Bajuk B, Ward M, et al. Neurodevelopmental outcomes of extremely premature infants conceived after assisted conception: a population based cohort study. Arch Dis Child Fetal Neonatal Ed, 2013, 98(3): F205-F211.
22. Yu VY. Assisted reproduction technology, multiple births, and adverse perinatal outcome. Croat Med J, 1998, 39(2): 208-211.
23. Kettner LO, Ramlau-Hansen CH, Kesmodel US, et al. Parental infertility, fertility treatment, and childhood epilepsy: a population-based cohort study. Paediatr Perinat Epidemiol, 2016, 30(5): 488-495.
24. Sun Y, Vestergaard M, Christensen J, et al. Epilepsy and febrile seizures in children of treated and untreated subfertile couples. Hum Reprod, 2007, 22(1): 215-220.
25. Ericson A, Nygren KG, Olausson PO, et al. Hospital care utilization of infants born after IVF. Hum Reprod, 2002, 17(4): 929-932.
26. 殷林亮. 辅助生殖技术受孕胎儿颅内结构发育的产前超声研究. 苏州: 苏州大学, 2013.
27. 陈丹. 辅助生殖技术受孕新生儿疾病特点及 6 月龄神经发育预后的研究. 郑州: 郑州大学, 2013.

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辅助生殖技术与子代神经系统疾病的相关性研究回顾

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