Soft silicone dressing in the treatment of acute radiation dermatitis of head and neck tumors: a meta-analysis_West China Medical Journal

Authors：

SHEN Yue ¹ , TAO Shiqi ² , ZHOU Wei ¹ ,  WAN Yonghui ¹

1. Department of Oncology, Renmin Hospital of Wuhan Univerisity, Wuhan, Hubei 430060, P. R. China;
2. Kunming Medical University School of Nursing, Kunming, Yunnan 650500, P. R. China;

Corresponding author：

WAN Yonghui, Email: 2691749068@qq.com

Keywords：

Radiodermatitis; Soft silicone dressing; Meta-analysis

DOI：

10.7507/1002-0179.201904031

Video：

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Objective To evaluate the effect of soft silicone dressing in radiation dermatitis after radiotherapy for head and neck tumors.Methods The data of Cochrane Library, Web of Science, JBI Library, CINAHL, Embase, Medline, China National Knowledge Infrastructure, Wanfang Database and Chinese Biomedical Literature Database were searched by computer, and the literature of soft silicone dressing in the treatment of radiation dermatitis were collected. The intervention group was treated with soft silicone dressing and the control group was treated with burn ointment and other methods. The retrieval time was from their inception to March 2019. After screening, quality evaluation and data extraction by two independent evaluators, meta-analysis was carried out by RevMan 5.3 software.Results A total of 7 articles were included, including 2 in English and 5 in Chinese, with a total of 487 patients. The results of meta-analysis showed that soft silicone dressing could shorten the wound healing time of radiation dermatitis [mean difference=−4.05 days, 95% confidence interval (CI) (−6.69, −1.42) days, P=0.003], reduce the severity of radiation dermatitis symptoms rated by the Radiation Therapy Oncology Group grade [odds ratio =7.99, 95% CI (2.69, 23.75), P=0.000 2], and reduce the score of Radiation-Induced Skin Reaction Assessment Scale (RISRAS) [standardized mean difference=−1.32, 95%CI (−2.64, −0.00), P=0.05]. To some extent, the curative effect was better than that of other methods. Wound healing time and RISRAS score combined with heterogeneity, after sensitivity analysis, the results were stable. Conclusion Soft silicone dressing can improve the concomitant symptoms of radiation dermatitis after radiotherapy of head and neck tumor, and may relieve the pain of radiation dermatitis to a certain extent, and promote the healing speed of dermatitis wound.

Citation： SHEN Yue, TAO Shiqi, ZHOU Wei, WAN Yonghui. Soft silicone dressing in the treatment of acute radiation dermatitis of head and neck tumors: a meta-analysis. West China Medical Journal, 2019, 34(11): 1285-1291. doi: 10.7507/1002-0179.201904031 Copy

1.	O’Donovan A, Coleman M, Harris R, et al. Prophylaxis and management of acute radiation-induced skin toxicity: a survey of practice across Europe and the USA. Eur J Cancer Care (Engl), 2015, 24(3): 425-435.
2.	Ryan JL, Heckler CE, Ling M, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res, 2013, 180(1): 34-43.
3.	Huang CJ, Hou MF, Luo KH, et al. RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements. Breast, 2015, 24(3): 230-236.
4.	Feight D, Baney T, Bruce S, et al. Putting evidence into practice. Clin J Oncol Nurs, 2011, 15(5): 481-492.
5.	王小玲, 赵慧莉, 彭峥嵘. 软聚硅酮泡沫敷料治疗压疮疗效的系统评价. 护理学杂志, 2013, 28(11): 79-83.
6.	Noble-Adams R. Radiation-induced skin reactions. 3: evaluating the RISRAS. Br J Nurs, 1999, 8(19): 1305-1312.
7.	Higgins JP, Altman DG, Gøtzsche PC, et al. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 2011, 343: d5928.
8.	Wooding H, Yan J, Yuan L, et al. The effect of mepitel film on acute radiation-induced skin reactions in head and neck cancer patients: a feasibility study. Br J Radiol, 2018, 91(1081): 20170298.
9.	Zhong WH, Tang QF, Hu LY, et al. Mepilex lite dressings for managing acute radiation dermatitis in nasopharyngeal carcinoma patients: a systematic controlled clinical trial. Med Oncol, 2013, 30(4): 761.
10.	凃桂红, 许春娇, 朱贝贝. 软聚硅酮泡沫敷料在放射性湿性皮炎中的临床应用. 护理研究, 2011, 25(9C): 2510-2511.
11.	吕雪琴, 艾玲, 徐德静. 美菲透明膜在鼻咽癌放疗患者颈部皮肤护理中的应用. 护理实践与研究, 2017, 14(24): 104-105.
12.	夏莉娟, 张曦, 孙青, 等. 鼻咽癌同步放化疗致重度放射性皮炎不同治疗方法的比较. 护理学杂志, 2018, 33(23): 12-14.
13.	李菁华. 不同敷料护理干预对放射治疗鼻咽癌患者皮肤损伤及情绪的影响. 中国医学创新, 2015, 12(19): 120-123.
14.	陈三妹, 焦迎春, 唐四元, 等. 鼻咽癌放射治疗患者颈部皮肤护理干预效果比较. 中华护理杂志, 2013, 48(6): 542-545.
15.	Winter GD. Formation of the scab and the rate of epithelisation of superficial wounds in the skin of the young domestic pig. 1962. J Wound Care, 1995, 4(8): 366-367, discussion 368-371.
16.	Costa MM, Silva SB, Quinto AL, et al. Phototherapy 660 nm for the prevention of radiodermatitis in breast cancer patients receiving radiation therapy: study protocol for a randomized controlled trial. Trials, 2014, 15: 330.
17.	Noble-Adams R. Radiation-induced skin reactions. 2: development of a measurement tool. Br J Nurs, 1999, 8(18): 1208-1211.
18.	Censabella S, Claes S, Robijns J, et al. Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS(®) laser therapy in breast cancer patients. Support Care Cancer, 2016, 24(9): 3925-3933.
19.	Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys, 1995, 31(5): 1341-1346.
20.	许春娇, 涂桂红, 宋爱梅. 美皮康在放射性湿性皮炎中的应用. 护理学杂志, 2010, 25(23): 73.
21.	Mak SS, Zee CY, Molassiotis A, et al. A comparison of wound treatments in nasopharyngeal cancer patients receiving radiation therapy. Cancer Nurs, 2005, 28(6): 436-445.

1. O’Donovan A, Coleman M, Harris R, et al. Prophylaxis and management of acute radiation-induced skin toxicity: a survey of practice across Europe and the USA. Eur J Cancer Care (Engl), 2015, 24(3): 425-435.
2. Ryan JL, Heckler CE, Ling M, et al. Curcumin for radiation dermatitis: a randomized, double-blind, placebo-controlled clinical trial of thirty breast cancer patients. Radiat Res, 2013, 180(1): 34-43.
3. Huang CJ, Hou MF, Luo KH, et al. RTOG, CTCAE and WHO criteria for acute radiation dermatitis correlate with cutaneous blood flow measurements. Breast, 2015, 24(3): 230-236.
4. Feight D, Baney T, Bruce S, et al. Putting evidence into practice. Clin J Oncol Nurs, 2011, 15(5): 481-492.
5. 王小玲, 赵慧莉, 彭峥嵘. 软聚硅酮泡沫敷料治疗压疮疗效的系统评价. 护理学杂志, 2013, 28(11): 79-83.
6. Noble-Adams R. Radiation-induced skin reactions. 3: evaluating the RISRAS. Br J Nurs, 1999, 8(19): 1305-1312.
7. Higgins JP, Altman DG, Gøtzsche PC, et al. The cochrane collaboration’s tool for assessing risk of bias in randomised trials. BMJ, 2011, 343: d5928.
8. Wooding H, Yan J, Yuan L, et al. The effect of mepitel film on acute radiation-induced skin reactions in head and neck cancer patients: a feasibility study. Br J Radiol, 2018, 91(1081): 20170298.
9. Zhong WH, Tang QF, Hu LY, et al. Mepilex lite dressings for managing acute radiation dermatitis in nasopharyngeal carcinoma patients: a systematic controlled clinical trial. Med Oncol, 2013, 30(4): 761.
10. 凃桂红, 许春娇, 朱贝贝. 软聚硅酮泡沫敷料在放射性湿性皮炎中的临床应用. 护理研究, 2011, 25(9C): 2510-2511.
11. 吕雪琴, 艾玲, 徐德静. 美菲透明膜在鼻咽癌放疗患者颈部皮肤护理中的应用. 护理实践与研究, 2017, 14(24): 104-105.
12. 夏莉娟, 张曦, 孙青, 等. 鼻咽癌同步放化疗致重度放射性皮炎不同治疗方法的比较. 护理学杂志, 2018, 33(23): 12-14.
13. 李菁华. 不同敷料护理干预对放射治疗鼻咽癌患者皮肤损伤及情绪的影响. 中国医学创新, 2015, 12(19): 120-123.
14. 陈三妹, 焦迎春, 唐四元, 等. 鼻咽癌放射治疗患者颈部皮肤护理干预效果比较. 中华护理杂志, 2013, 48(6): 542-545.
15. Winter GD. Formation of the scab and the rate of epithelisation of superficial wounds in the skin of the young domestic pig. 1962. J Wound Care, 1995, 4(8): 366-367, discussion 368-371.
16. Costa MM, Silva SB, Quinto AL, et al. Phototherapy 660 nm for the prevention of radiodermatitis in breast cancer patients receiving radiation therapy: study protocol for a randomized controlled trial. Trials, 2014, 15: 330.
17. Noble-Adams R. Radiation-induced skin reactions. 2: development of a measurement tool. Br J Nurs, 1999, 8(18): 1208-1211.
18. Censabella S, Claes S, Robijns J, et al. Photobiomodulation for the management of radiation dermatitis: the DERMIS trial, a pilot study of MLS(®) laser therapy in breast cancer patients. Support Care Cancer, 2016, 24(9): 3925-3933.
19. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys, 1995, 31(5): 1341-1346.
20. 许春娇, 涂桂红, 宋爱梅. 美皮康在放射性湿性皮炎中的应用. 护理学杂志, 2010, 25(23): 73.
21. Mak SS, Zee CY, Molassiotis A, et al. A comparison of wound treatments in nasopharyngeal cancer patients receiving radiation therapy. Cancer Nurs, 2005, 28(6): 436-445.

West China Medical Journal

Soft silicone dressing in the treatment of acute radiation dermatitis of head and neck tumors: a meta-analysis

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