Status quo of nurses’ cognition of skin test of β-lactam antibiotics in tertiary hospital_West China Medical Journal

Authors：

JI Dandan ¹ , HU Bijie ² , GAO Xiaodong ³ , ZHENG Zheng ¹ ,  YUAN Zheng ¹

1. Nursing Department, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;
2. Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;
3. Department of Hospital Infection Management, Zhongshan Hospital, Fudan University, Shanghai 200032, P. R. China;

Corresponding author：

YUAN Zheng, Email: yuan.zheng@zs-hospital.sh.cn

Keywords：

β-lactam antibiotics; skin test; multi-center; allergy

DOI：

10.7507/1002-0179.202401074

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

Objective To investigate the status of nurses’ cognition of skin test for β-lactam antibiotics in tertiary hospitals in China and its influencing factors. Methods The nurses in the eastern and western regions were selected by stratified sampling and convenient sampling between March and May 2023. A multi-center survey was conducted with the help of the questionnaire star platform using the “Questionnaire on the Cognitive Status of β-lactam Antibiotics Skin Test” developed by the “Guidelines for β-lactam Antibiotics Skin Test (2021 Edition)” issued by the National Health Commission of the reference country. Results A total of 89 tertiary hospitals were surveyed. Among them, there were 27 in the eastern regions and 62 in the western regions; There were 64 comprehensive hospitals and 25 specialized hospitals. A total of 4 241 nurses were included. Among them, 4 151 were females and 90 were males. The scores of nurses’ cognition of skin test of β-lactam antibiotics were (61.47±16.27). The survey results showed that the accuracy rate ranges from 15.52% to 88.98%. Only no routine skin test before cephalosporin administration, judgment of skin test results, and infusion device replacement after allergy were greater than 80%. The results of the logistic regression analysis showed that the nurses with professional titles and antimicrobial management training in the past 2 years were independent influencing factors of nurses’ cognition of skin test of β-lactam antibiotics (P<0.001). Conclusions At present, nurses in tertiary hospitals in China still have insufficient knowledge of skin test of β-lactam antibiotics. It is suggested that hospitals should form corresponding hospital skin test of β-lactam antibiotics standards in combination with guidelines and strengthen training for nurses in this regard, so as to improve nurses’ correct cognition and implementation of skin test of β-lactam antibiotics.

Citation： JI Dandan, HU Bijie, GAO Xiaodong, ZHENG Zheng, YUAN Zheng. Status quo of nurses’ cognition of skin test of β-lactam antibiotics in tertiary hospital. West China Medical Journal, 2024, 39(3): 455-460. doi: 10.7507/1002-0179.202401074 Copy

1.	何艳, 章登政, 付伟, 等. 湖北省内医疗机构β-内酰胺类抗菌药物皮肤试验现状调查分析. 中国医院药学杂志, 2020, 40(18): 1937-1941, 1991.
2.	赵昕, 张海霞, 程青, 等. β-内酰胺类抗菌药物皮试的国内现状调查. 儿科药学杂志, 2018, 24(11): 30-34.
3.	许锦英, 盛雪鹤, 刘孟雪, 等. 皖南地区 18 所公立医院β-内酰胺类抗菌药物皮肤过敏试验现状分析. 安徽医药, 2017, 21(5): 943-947.
4.	中华人民共和国国家卫生健康委员会. β内酰胺类抗菌药物皮肤试验指导原则(2021 年版). 中国实用乡村医生杂志, 2021, 28(5): 1-4.
5.	许译尹, 余霞霞, 张学丽, 等. 《β-内酰胺类抗菌药物皮肤试验指导原则(2021 年版)》医疗机构执行情况调研分析. 中国抗生素杂志, 2023, 48(10): 1177-1182.
6.	Kelley TL. The selection of upper and lower groups for the validation of test items. J Educ Psychology, 1939, 30(1): 17-24.
7.	陈敏, 黄敏, 邓兰兰. 某市青霉素及头孢类抗菌药物皮肤过敏试验现状调查研究. 中国药业, 2016, 25(5): 4-6.
8.	中华预防医学会过敏病预防与控制专业委员会预防食物药物过敏学组. 药物过敏诊断和预防方案中国专家共识. 中华预防医学杂志, 2022, 56(6): 682-706.
9.	Torres MJ, Romano A, Celik G, et al. Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. Clin Transl Allergy, 2017, 7: 7.
10.	蒋子涵, 肖浩, 孟娟. 华西医院住院患者“青霉素过敏史”相关问卷调查. 中华临床免疫和变态反应杂志, 2022, 16(6): 589-594.
11.	张筱璇, 汤智慧, 朱曼, 等. 国内部分医院β-内酰胺类抗生素皮肤试验现状调查分析. 药物流行病学杂志, 2018, 27(1): 33-37.
12.	邹鹤娟, 李颖, 吕娟丽, 等. 全国医疗机构头孢菌素皮试现状分析. 中国感染与化疗杂志, 2023, 23(1): 14-19.
13.	Blumenthal KG, Kuper K, Schulz LT, et al. Association between penicillin allergy documentation and antibiotic use. JAMA Intern Med, 2020, 180(8): 1120-1122.
14.	Oliver WD, Heil EL, Thom KA, et al. Allergy profile should be updated after uneventful administration of a penicillin or penicillin-related antibiotic to a patient with penicillin allergy. J Allergy Clin Immunol Pract, 2017, 5(1): 184-186.
15.	赵红福. 外科护士参与抗菌药物管理知信行现状调查. 当代护士(上旬刊), 2022, 29(9): 146-149.
16.	Berger RE, Singh HK, Loo AS, et al. Improving antibiotic stewardship for inpatients with reported beta-lactam allergies and limited access to penicillin skin testing. Jt Comm J Qual Patient Saf, 2022, 48(3): 147-153.
17.	Barbaud A, Weinborn M, Garvey LH, et al. Intradermal tests with drugs: an approach to standardization. Front Med (Lausanne), 2020, 7: 156.
18.	King EA, Challa S, Curtin P, et al. Penicillin skin testing in hospitalized patients with β-lactam allergies: effect on antibiotic selection and cost. Ann Allergy Asthma Immunol, 2016, 117(1): 67-71.

1. 何艳, 章登政, 付伟, 等. 湖北省内医疗机构β-内酰胺类抗菌药物皮肤试验现状调查分析. 中国医院药学杂志, 2020, 40(18): 1937-1941, 1991.
2. 赵昕, 张海霞, 程青, 等. β-内酰胺类抗菌药物皮试的国内现状调查. 儿科药学杂志, 2018, 24(11): 30-34.
3. 许锦英, 盛雪鹤, 刘孟雪, 等. 皖南地区 18 所公立医院β-内酰胺类抗菌药物皮肤过敏试验现状分析. 安徽医药, 2017, 21(5): 943-947.
4. 中华人民共和国国家卫生健康委员会. β内酰胺类抗菌药物皮肤试验指导原则(2021 年版). 中国实用乡村医生杂志, 2021, 28(5): 1-4.
5. 许译尹, 余霞霞, 张学丽, 等. 《β-内酰胺类抗菌药物皮肤试验指导原则(2021 年版)》医疗机构执行情况调研分析. 中国抗生素杂志, 2023, 48(10): 1177-1182.
6. Kelley TL. The selection of upper and lower groups for the validation of test items. J Educ Psychology, 1939, 30(1): 17-24.
7. 陈敏, 黄敏, 邓兰兰. 某市青霉素及头孢类抗菌药物皮肤过敏试验现状调查研究. 中国药业, 2016, 25(5): 4-6.
8. 中华预防医学会过敏病预防与控制专业委员会预防食物药物过敏学组. 药物过敏诊断和预防方案中国专家共识. 中华预防医学杂志, 2022, 56(6): 682-706.
9. Torres MJ, Romano A, Celik G, et al. Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America. Clin Transl Allergy, 2017, 7: 7.
10. 蒋子涵, 肖浩, 孟娟. 华西医院住院患者“青霉素过敏史”相关问卷调查. 中华临床免疫和变态反应杂志, 2022, 16(6): 589-594.
11. 张筱璇, 汤智慧, 朱曼, 等. 国内部分医院β-内酰胺类抗生素皮肤试验现状调查分析. 药物流行病学杂志, 2018, 27(1): 33-37.
12. 邹鹤娟, 李颖, 吕娟丽, 等. 全国医疗机构头孢菌素皮试现状分析. 中国感染与化疗杂志, 2023, 23(1): 14-19.
13. Blumenthal KG, Kuper K, Schulz LT, et al. Association between penicillin allergy documentation and antibiotic use. JAMA Intern Med, 2020, 180(8): 1120-1122.
14. Oliver WD, Heil EL, Thom KA, et al. Allergy profile should be updated after uneventful administration of a penicillin or penicillin-related antibiotic to a patient with penicillin allergy. J Allergy Clin Immunol Pract, 2017, 5(1): 184-186.
15. 赵红福. 外科护士参与抗菌药物管理知信行现状调查. 当代护士(上旬刊), 2022, 29(9): 146-149.
16. Berger RE, Singh HK, Loo AS, et al. Improving antibiotic stewardship for inpatients with reported beta-lactam allergies and limited access to penicillin skin testing. Jt Comm J Qual Patient Saf, 2022, 48(3): 147-153.
17. Barbaud A, Weinborn M, Garvey LH, et al. Intradermal tests with drugs: an approach to standardization. Front Med (Lausanne), 2020, 7: 156.
18. King EA, Challa S, Curtin P, et al. Penicillin skin testing in hospitalized patients with β-lactam allergies: effect on antibiotic selection and cost. Ann Allergy Asthma Immunol, 2016, 117(1): 67-71.

West China Medical Journal

Status quo of nurses’ cognition of skin test of β-lactam antibiotics in tertiary hospital

Abstract Full text Figures/Tables Video References Cited by

Previous Article

Next Article

Format

Content