Research progress of sleeve gastrectomy with jejunojejunal bypass_West China Medical Journal

Authors：

WANG Lang ¹ ,  DING Yinlu ²

1. Second Clinical College of Shandong University, Jinan, Shandong 250012, P. R. China;
2. Gastrointestinal Surgery Department, Second Hospital of Shandong University, Jinan, Shandong 250012, P. R. China;

Corresponding author：

DING Yinlu, Email: dingyinlu@126.com

Keywords：

Sleeve gastrectomy; jejunojejunal bypass; Roux-en-Y gastric bypass; obesity

DOI：

10.7507/1002-0179.202407321

Video：

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Abstract Full text Figures/Tables Video References Cited by

With the swift evolution of bariatric and metabolic surgery, additional procedures building upon sleeve gastrectomy have consistently surfaced. Recent studies suggest that sleeve gastrectomy with jejunojejunal bypass (SG-JJB) yields superior short-term weight reduction outcomes compared to sleeve gastrectomy alone, with weight loss and glycemic control effects akin to Roux-en-Y gastric bypass, and without significant complications. As a result, SG-JJB is regarded as a safe and efficacious bariatric procedure, noted for its technical simplicity and reversibility, presenting substantial clinical utility. Nonetheless, high-quality, multicenter, large-sample, long-term follow-up randomized controlled trials are essential to further ascertain its long-term efficacy and safety, and to facilitate its standardized implementation. This article seeks to review the advancements in SG-JJB research, evaluate its effectiveness and safety in managing obesity and associated comorbidities, and explore its future developmental trajectory.

Citation： WANG Lang, DING Yinlu. Research progress of sleeve gastrectomy with jejunojejunal bypass. West China Medical Journal, 2025, 40(2): 305-312. doi: 10.7507/1002-0179.202407321 Copy

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1. Boutari C, Mantzoros CS. A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on. Metabolism, 2022, 133: 155217.
2. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet, 2024, 403(10431): 1027-1050.
3. Okunogbe A, Nugent R, Spencer G, et al. Economic impacts of overweight and obesity: current and future estimates for 161 countries. BMJ Glob Health, 2022, 7(9): e009773.
4. GBD 2021 Risk Factors Collaborators. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet, 2024, 403(10440): 2162-2203.
5. Kloock S, Ziegler CG, Dischinger U. Obesity and its comorbidities, current treatment options and future perspectives: challenging bariatric surgery?. Pharmacol Ther, 2023, 251: 108549.
6. Brown WA, Liem R, Al-Sabah S, et al. Metabolic bariatric surgery across the IFSO chapters: key insights on the baseline patient demographics, procedure types, and mortality from the eighth IFSO global registry report. Obes Surg, 2024, 34(5): 1764-1777.
7. Biter LU, ’t Hart JW, Noordman BJ, et al. Long-term effect of sleeve gastrectomy vs Roux-en-Y gastric bypass in people living with severe obesity: a phase Ⅲ multicentre randomised controlled trial (SleeveBypass). Lancet Reg Health Eur, 2024, 38: 100836.
8. Dang JT, Vaughan T, Mocanu V, et al. Conversion of sleeve gastrectomy to Roux-en-Y gastric bypass: indications, prevalence, and safety. Obes Surg, 2023, 33(5): 1486-1493.
9. Nielsen HJ, Nedrebø BG, Fosså A, et al. Seven-year trajectories of body weight, quality of life and comorbidities following Roux-en-Y gastric bypass and sleeve gastrectomy. Int J Obes (Lond), 2022, 46(4): 739-749.
10. Kim JC, Kim MG, Park JK, et al. Outcomes and adverse events after bariatric surgery: an updated systematic review and meta-analysis, 2013-2023. J Metab Bariatr Surg, 2023, 12(2): 76-88.
11. 王涛, 师振, 于飞. 不同手术方案治疗重度肥胖合并 2 型糖尿病疗效比较. 新乡医学院学报, 2022, 39(4): 371-375.
12. Huang CK, Mahendra R, Hsin MC, et al. Novel metabolic surgery: first Asia series and short-term results of laparoscopic proximal jejunal bypass with sleeve gastrectomy. Ann Laparosc Endosc Surg, 2016, 1: 37.
13. 李梦伊, 刘雁军, 王桂琦, 等. 大中华减重与代谢手术数据库 2023 年度报告. 中国实用外科杂志, 2024, 44(5): 552-563, 570.
14. 中国医师协会外科医师分会肥胖和代谢病外科专家工作组, 中国医师协会外科医师分会肥胖代谢外科综合管理专家工作组, 中国肥胖代谢外科研究协作组. 中国肥胖代谢外科数据库: 2023 年度报告. 中华肥胖与代谢病电子杂志, 2024, 10(2): 73-83.
15. Lin S, Li C, Guan W, et al. Three-year outcomes of sleeve gastrectomy plus jejunojejunal bypass: a retrospective case-matched study with sleeve gastrectomy and gastric bypass in Chinese patients with BMI ≥35 kg/m². Obes Surg, 2021, 31(8): 3525-3530.
16. Alamo Alamo M, Sepúlveda Torres C, Zapata Perez L. Vertical isolated gastroplasty with gastro-enteral bypass: preliminary results. Obes Surg, 2006, 16(3): 353-358.
17. de Menezes Ettinger JE, Azaro E, Mello CA, et al. Analysis of the vertical isolated gastroplasty: a new bariatric operation. Obes Surg, 2006, 16(9): 1261-1263.
18. Alamo M, Sepúlveda M, Gellona J, et al. Sleeve gastrectomy with jejunal bypass for the treatment of type 2 diabetes mellitus in patients with body mass index <35 kg/m². A cohort study. Obes Surg, 2012, 22(7): 1097-1103.
19. 梁辉. 袖状胃切除加空肠旷置术的研究现状. 中华胃肠外科杂志, 2022, 25(10): 886-891.
20. Sridhar A, Khan D, Abdelaal M, et al. Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats. PLoS One, 2022, 17(9): e0274788.
21. 罗衡桂, 唐彬, 毛岳峰, 等. 不同类型减重代谢手术治疗重度肥胖合并 2 型糖尿病的近期疗效分析. 中国普通外科杂志, 2020, 29(10): 1224-1233.
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