Application progress and thinking of digital therapeutics in orthopedics_West China Medical Journal

Authors：

LI Peifang , ZHOU Zongke ,  CHEN Jiali ,  NING Ning

Department of Orthopedic Surgery, West China Hospital, Sichuan University / West China School of Nursing, Sichuan University, Chengdu, Sichuan 610041, P. R. China;

Corresponding author：

CHEN Jiali, Email: cjl85614115@163.com; NING Ning, Email: gkningning@126.com

Keywords：

Digital therapeutics; orthopedics; digital health

DOI：

10.7507/1002-0179.202408388

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In recent years, the rapid development of information and communication technology, big data, and artificial intelligence has provided technical support for exploring new medical methods, leading to the emergence of digital therapeutics (DTx). At present, the application of DTx in orthopedics is still in the preliminary exploration stage. Therefore, based on the authors’ experience of applying DTx, this article summarizes the definition and formation process of DTx, as well as the relationship among digital health, digital medicine, and DTx, evaluates the working principles and application effects of existing orthopedic related DTx products, analyzes their shortcomings in the application process, and looks forward to their future development trends, aiming to lay a foundation for the comprehensive development and application of DTx in orthopedics.

Citation： LI Peifang, ZHOU Zongke, CHEN Jiali, NING Ning. Application progress and thinking of digital therapeutics in orthopedics. West China Medical Journal, 2024, 39(10): 1509-1513. doi: 10.7507/1002-0179.202408388 Copy

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14.	黄如意, 井淇. 数字化时代的数字健康: 内涵、特征、挑战与治理路径. 卫生经济研究, 2022, 39(6): 60-63, 66.
15.	张汉卿, 孙鑫章, 熊丹莉, 等. 数字医疗在结直肠癌护理的研究现状及发展趋势. 护士进修杂志, 2023, 38(17): 1577-1581.
16.	Nomura A. Digital health, digital medicine, and digital therapeutics in cardiology: current evidence and future perspective in Japan. Hypertens Res, 2023, 46(9): 2126-2134.
17.	Patel NA, Butte AJ. Characteristics and challenges of the clinical pipeline of digital therapeutics. NPJ Digit Med, 2020, 3(1): 159.
18.	Garcia LM, Darnall BD, Krishnamurthy P, et al. Self-administered behavioral skills-based at-home virtual reality therapy for chronic low back pain: protocol for a randomized controlled trial. JMIR Res Protoc, 2021, 10(1): e25291.
19.	Garcia LM, Birckhead BJ, Krishnamurthy P, et al. An 8-week self-administered at-home behavioral skills-based virtual reality program for chronic low back pain: double-blind, randomized, placebo-controlled trial conducted during COVID-19. J Med Internet Res, 2021, 23(2): e26292.
20.	Garcia L, Birckhead B, Krishnamurthy P, et al. Durability of the treatment effects of an 8-week self-administered home-based virtual reality program for chronic low back pain: 6-month follow-up study of a randomized clinical trial. J Med Internet Res, 2022, 24(5): e37480.
21.	Bailey JF, Agarwal V, Zheng P, et al. Digital care for chronic musculoskeletal pain: 10, 000 participant longitudinal cohort study. J Med Internet Res, 2020, 22(5): e18250.
22.	周易, 张鑫, 王虹舒, 等. 数字疗法在膝关节前交叉韧带术后康复中的应用. 中国医疗器械杂志, 2023, 47(5): 487-491.
23.	夏雪. 数字赋能下我国运动数字疗法产业生态研究. 武汉: 武汉体育学院, 2023.

1. 杨吉江, 雷毅, 武文杰, 等. 数字疗法发展与应用综述研究. 中国卫生信息管理杂志, 2022, 19(2): 211-216.
2. 孙鹏, 徐宜蕙, 张一帆, 等. 数字疗法产品监管过程中的焦点问题调研. 中国医学装备, 2022, 19(11): 8-13.
3. Murray CJ, Vos T, Lozano R, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, 380(9859): 2197-2223.
4. 陈青松. 工作相关肌肉骨骼疾患及其防控. 环境与职业医学, 2023, 40(1): 1-5.
5. Qaseem A, Wilt TJ, McLean RM, et al. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the american college of physicians. Ann Intern Med, 2017, 166(7): 514-530.
6. Moseley JB, O’Malley K, Petersen NJ, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med, 2002, 347(2): 81-88.
7. Delitto A, Piva SR, Moore CG, et al. Surgery versus nonsurgical treatment of lumbar spinal stenosis: a randomized trial. Ann Intern Med, 2015, 162(7): 465-473.
8. Slattery BW, Haugh S, O’Connor L, et al. An evaluation of the effectiveness of the modalities used to deliver electronic health interventions for chronic pain: systematic review with network meta-analysis. J Med Internet Res, 2019, 21(7): e11086.
9. Dorflinger L, Kerns RD, Auerbach SM. Providers’ roles in enhancing patients’ adherence to pain self management. Transl Behav Med, 2013, 3(1): 39-46.
10. Tong F, Lederman R, D’Alfonso S, et al. Digital therapeutic alliance with fully automated mental health smartphone apps: a narrative review. Front Psychiatry, 2022, 13: 819623.
11. 徐宜蕙, 张一帆, 李杨, 等. 美国 FDA 批准的数字疗法产品临床试验设计研究. 中国医学装备, 2022, 19(11): 1-7.
12. 张一帆, 刘昱鑫, 刘毅, 等. 用于精神类疾病治疗的数字疗法产品可用性评估特性. 中国医学装备, 2022, 19(11): 14-18.
13. Mariano B. Towards a global strategy on digital health. Bull World Health Organ, 2020, 98(4): 231-231A.
14. 黄如意, 井淇. 数字化时代的数字健康: 内涵、特征、挑战与治理路径. 卫生经济研究, 2022, 39(6): 60-63, 66.
15. 张汉卿, 孙鑫章, 熊丹莉, 等. 数字医疗在结直肠癌护理的研究现状及发展趋势. 护士进修杂志, 2023, 38(17): 1577-1581.
16. Nomura A. Digital health, digital medicine, and digital therapeutics in cardiology: current evidence and future perspective in Japan. Hypertens Res, 2023, 46(9): 2126-2134.
17. Patel NA, Butte AJ. Characteristics and challenges of the clinical pipeline of digital therapeutics. NPJ Digit Med, 2020, 3(1): 159.
18. Garcia LM, Darnall BD, Krishnamurthy P, et al. Self-administered behavioral skills-based at-home virtual reality therapy for chronic low back pain: protocol for a randomized controlled trial. JMIR Res Protoc, 2021, 10(1): e25291.
19. Garcia LM, Birckhead BJ, Krishnamurthy P, et al. An 8-week self-administered at-home behavioral skills-based virtual reality program for chronic low back pain: double-blind, randomized, placebo-controlled trial conducted during COVID-19. J Med Internet Res, 2021, 23(2): e26292.
20. Garcia L, Birckhead B, Krishnamurthy P, et al. Durability of the treatment effects of an 8-week self-administered home-based virtual reality program for chronic low back pain: 6-month follow-up study of a randomized clinical trial. J Med Internet Res, 2022, 24(5): e37480.
21. Bailey JF, Agarwal V, Zheng P, et al. Digital care for chronic musculoskeletal pain: 10, 000 participant longitudinal cohort study. J Med Internet Res, 2020, 22(5): e18250.
22. 周易, 张鑫, 王虹舒, 等. 数字疗法在膝关节前交叉韧带术后康复中的应用. 中国医疗器械杂志, 2023, 47(5): 487-491.
23. 夏雪. 数字赋能下我国运动数字疗法产业生态研究. 武汉: 武汉体育学院, 2023.

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