Research progress of mechanisms of sclerostin in vascular calcification and atherosclerotic heart disease_West China Medical Journal

Authors：

YANG Hao , XU Jing , LI Fandan , DU Xiaoliang ,  LÜ Zhan

Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, P. R. China;

Corresponding author：

LÜ Zhan, Email: Doctor_LZ@163.com

Keywords：

Sclerostin; vascular calcification; atherosclerosis; cardiovascular disease

DOI：

10.7507/1002-0179.202409006

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Sclerostin, as a bone-derived secreted glycoprotein, is a suppressor of Wnt signaling pathway. Recently, adverse cardiovascular events in the treatment of osteoporosis with sclerostin inhibitors have raised concerns about the association of sclerostin with atherosclerotic heart disease. Whether the role of sclerostin in atherosclerotic heart disease is harmful or beneficial is not clear. This article reviews the progress of the mechanisms of sclerostin in vascular calcification and atherosclerotic heart disease, focusing on the relationship between sclerostin and vascular calcification, the impact of its concentration changes on atherosclerotic heart disease, and the effect of sclerostin inhibitor on cardiovascular events.

Citation： YANG Hao, XU Jing, LI Fandan, DU Xiaoliang, LÜ Zhan. Research progress of mechanisms of sclerostin in vascular calcification and atherosclerotic heart disease. West China Medical Journal, 2024, 39(12): 1953-1957. doi: 10.7507/1002-0179.202409006 Copy

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19.	Staley JR, Giannakopoulou O, Holdsworth G, et al. Genetic data do not provide evidence that lower sclerostin is associated with increased risk of atherosclerosis: comment on the article by Zheng et al. Arthritis Rheumatol, 2023: 1-2.
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19. Staley JR, Giannakopoulou O, Holdsworth G, et al. Genetic data do not provide evidence that lower sclerostin is associated with increased risk of atherosclerosis: comment on the article by Zheng et al. Arthritis Rheumatol, 2023: 1-2.
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Research progress of mechanisms of sclerostin in vascular calcification and atherosclerotic heart disease

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