获得性凝血因子ⅩⅢ缺乏症一例_West China Medical Journal

Authors：

熊艳秋 ¹ , 易海 ^2,3,4 , 邹忠晴 ¹ ,  饶进 ¹

1. ;
2. ;
3. ;
4. ;

Corresponding author：

饶进, Email: raojin720325@163.com

Keywords：

获得性凝血因子ⅩⅢ缺乏; 血肿; 免疫衰老; 清除抗体; 三步流程

DOI：

10.7507/1002-0179.202510068

Video：

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Abstract Full text Figures/Tables Video References Cited by

1.	Muszbek L, Katona É, Kerényi A. Assessment of Factor XIII. Methods Mol Biol, 2017, 1646: 277-293.
2.	Wiszniewska M, Włodarczyk U, Sury M, et al. The usefulness of factor XIII concentration assessment in patients in the acute phase of ischaemic stroke treated with thrombolysis. Neurol Int, 2024, 16(3): 551-560.
3.	Michalak M, Piróg A, Andruszkiewicz P, et al. Atypical postoperative bleeding as a first manifestation of acquired hemophilia a: a case report. Clin Med Insights Case Rep, 2025, 18: 11795476251391058.
4.	Yu R, Bowman M, Bonnefoy A, et al. Concomitant acquired hemophilia A and acquired von willebrand syndrome from distinctive autoantibodies: case report. Hematol Rep, 2025, 17(5): 52.
5.	Al Dawood R, Hayward CPM. Laboratory diagnosis of congenital and acquired coagulopathies, including challenging-to-diagnose rare bleeding disorders. Pathology, 2025, 57(6): 687-695.
6.	Tsunemine H, Souri M, Kumode W, et al. A case of autoimmune factor XIII deficiency due to clearance-accelerating and inhibitory anti-FXIII autoantibodies. Int J Hematol, 2025, 121(2): 257-264.
7.	Koduri A, Kakumani J, S MK. A rare case of congenital factor XIII deficiency secondary to hyperconsumption: a case report. Cureus, 2024, 16(11): e72910.
8.	Malkhassian D, Sabir S, Sharma S. Physiology, factor XIII//StatPearls. Treasure Island (FL): StatPearls Publishing, 2025.
9.	Jacobs JW, Booth GS, Costa V, et al. Factor XIII deficiency: a review of biology, testing, and treatment. Clin Hematol Int, 2026, 8(1): 10-25.
10.	von Meijenfeldt FA, Havervall S, Adelmeijer J, et al. COVID-19 is associated with an acquired Factor XIII deficiency. Thromb Haemost, 2021, 121(12): 1668-1669.
11.	Cahuapaza-Gutierrez NL, Calderon-Hernandez CC, Pajuelo-Vasquez R, et al. New-onset hematologic disorders following COVID-19 vaccination: a systematic review. Clin Exp Vaccine Res, 2025, 14(2): 169-184.
12.	Marco A, Marco P. Autoimmune acquired factor XIII deficiency: a case report. J Blood Med, 2021, 12: 63-68.
13.	Yan MTS, Rydz N, Goodyear D, et al. Acquired factor XIII deficiency: a review. Transfus Apher Sci, 2018, 57(6): 724-730.
14.	Cimé-Aké E, Lima G, Godínez-Lazarini E, et al. Immunosenescent and exhausted T cells in systemic lupus erythematosus patients with cognitive impairment. Clin Immunol, 2025, 282: 110635.
15.	Yin H, Zhou S, Shen K, et al. The pathogenic role of T cell metabolism and its effect on immune senescence in autoimmune diseases and infection. Clin Rev Allergy Immunol, 2025, 68(1): 95.
16.	Wu Y, Luo J, Lin J, et al. Immunosenescence: shaping the hematological narrative in the era of aging. Aging Dis, 2025: 1-25.
17.	Rodrigues LP, Teixeira VR, Alencar-Silva T, et al. Hallmarks of aging and immunosenescence: connecting the dots. Cytokine Growth Factor Rev, 2021, 59: 9-21.
18.	Hao Y, O’Neill P, Naradikian MS, et al. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood, 2011, 118(5): 1294-1304.
19.	Valentino TR, Chen N, Makhijani P, et al. The role of autoantibodies in bridging obesity, aging, and immunosenescence. Immun Ageing, 2024, 21(1): 85.
20.	Mouat IC, Goldberg E, Horwitz MS. Age-associated B cells in autoimmune diseases. Cell Mol Life Sci, 2022, 79(8): 402.
21.	Boehlen F, Casini A, Chizzolini C, et al. Acquired factor XIII deficiency: a therapeutic challenge. Thromb Haemost, 2013, 109(3): 479-487.
22.	Franchini M, Frattini F, Crestani S, et al. Acquired FXIII inhibitors: a systematic review. J Thromb Thrombolysis, 2013, 36(1): 109-114.
23.	Mangla A, Hamad H, Killeen RB, et al. Factor XIII Deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2025.
24.	Duranteau O, Tatar G, Demulder A, et al. Acquired factor XIII deficiency: a scoping review. Eur J Anaesthesiol Intensive Care, 2023, 2(5): e0035.
25.	Ichinose A; Japanese Collaborative Research Group on AH. Autoimmune acquired factor XIII deficiency due to anti-factor XIII/13 antibodies: a summary of 93 patients. Blood Rev, 2017, 31(1): 37-45.
26.	Souri M, Osaki T, Ichinose A. Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan. Int J Hematol, 2024, 120(4): 472-481.
27.	Smith J, Bodine JS, Cunningham MT, et al. Perioperative therapeutic plasma exchange in a patient with rare Factor XIII inhibitor. Transfus Apher Sci, 2023, 62(3): 103654.
28.	Song J, Liu L, Ding B, et al. Comparison of outcomes in autoimmune acquired factor XIII deficiency with and without underlying diseases: a systematic review. J Thromb Thrombolysis, 2025: 1-9.
29.	Ichinose A, Kohler HP, Philippou H, et al. Recommendation for ISTH/SSC criterion 2015 for autoimmune acquired factor XIII/13 deficiency. Thromb Haemost, 2016, 116(4): 772-774.
30.	赵倩, 刘畅, 刘荣. 多学科协作模式下穿透性胎盘植入伴膀胱侵犯的围产期管理1例. 数理医药学杂志, 2025, 38(8): 629-635.

1. Muszbek L, Katona É, Kerényi A. Assessment of Factor XIII. Methods Mol Biol, 2017, 1646: 277-293.
2. Wiszniewska M, Włodarczyk U, Sury M, et al. The usefulness of factor XIII concentration assessment in patients in the acute phase of ischaemic stroke treated with thrombolysis. Neurol Int, 2024, 16(3): 551-560.
3. Michalak M, Piróg A, Andruszkiewicz P, et al. Atypical postoperative bleeding as a first manifestation of acquired hemophilia a: a case report. Clin Med Insights Case Rep, 2025, 18: 11795476251391058.
4. Yu R, Bowman M, Bonnefoy A, et al. Concomitant acquired hemophilia A and acquired von willebrand syndrome from distinctive autoantibodies: case report. Hematol Rep, 2025, 17(5): 52.
5. Al Dawood R, Hayward CPM. Laboratory diagnosis of congenital and acquired coagulopathies, including challenging-to-diagnose rare bleeding disorders. Pathology, 2025, 57(6): 687-695.
6. Tsunemine H, Souri M, Kumode W, et al. A case of autoimmune factor XIII deficiency due to clearance-accelerating and inhibitory anti-FXIII autoantibodies. Int J Hematol, 2025, 121(2): 257-264.
7. Koduri A, Kakumani J, S MK. A rare case of congenital factor XIII deficiency secondary to hyperconsumption: a case report. Cureus, 2024, 16(11): e72910.
8. Malkhassian D, Sabir S, Sharma S. Physiology, factor XIII//StatPearls. Treasure Island (FL): StatPearls Publishing, 2025.
9. Jacobs JW, Booth GS, Costa V, et al. Factor XIII deficiency: a review of biology, testing, and treatment. Clin Hematol Int, 2026, 8(1): 10-25.
10. von Meijenfeldt FA, Havervall S, Adelmeijer J, et al. COVID-19 is associated with an acquired Factor XIII deficiency. Thromb Haemost, 2021, 121(12): 1668-1669.
11. Cahuapaza-Gutierrez NL, Calderon-Hernandez CC, Pajuelo-Vasquez R, et al. New-onset hematologic disorders following COVID-19 vaccination: a systematic review. Clin Exp Vaccine Res, 2025, 14(2): 169-184.
12. Marco A, Marco P. Autoimmune acquired factor XIII deficiency: a case report. J Blood Med, 2021, 12: 63-68.
13. Yan MTS, Rydz N, Goodyear D, et al. Acquired factor XIII deficiency: a review. Transfus Apher Sci, 2018, 57(6): 724-730.
14. Cimé-Aké E, Lima G, Godínez-Lazarini E, et al. Immunosenescent and exhausted T cells in systemic lupus erythematosus patients with cognitive impairment. Clin Immunol, 2025, 282: 110635.
15. Yin H, Zhou S, Shen K, et al. The pathogenic role of T cell metabolism and its effect on immune senescence in autoimmune diseases and infection. Clin Rev Allergy Immunol, 2025, 68(1): 95.
16. Wu Y, Luo J, Lin J, et al. Immunosenescence: shaping the hematological narrative in the era of aging. Aging Dis, 2025: 1-25.
17. Rodrigues LP, Teixeira VR, Alencar-Silva T, et al. Hallmarks of aging and immunosenescence: connecting the dots. Cytokine Growth Factor Rev, 2021, 59: 9-21.
18. Hao Y, O’Neill P, Naradikian MS, et al. A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice. Blood, 2011, 118(5): 1294-1304.
19. Valentino TR, Chen N, Makhijani P, et al. The role of autoantibodies in bridging obesity, aging, and immunosenescence. Immun Ageing, 2024, 21(1): 85.
20. Mouat IC, Goldberg E, Horwitz MS. Age-associated B cells in autoimmune diseases. Cell Mol Life Sci, 2022, 79(8): 402.
21. Boehlen F, Casini A, Chizzolini C, et al. Acquired factor XIII deficiency: a therapeutic challenge. Thromb Haemost, 2013, 109(3): 479-487.
22. Franchini M, Frattini F, Crestani S, et al. Acquired FXIII inhibitors: a systematic review. J Thromb Thrombolysis, 2013, 36(1): 109-114.
23. Mangla A, Hamad H, Killeen RB, et al. Factor XIII Deficiency. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2025.
24. Duranteau O, Tatar G, Demulder A, et al. Acquired factor XIII deficiency: a scoping review. Eur J Anaesthesiol Intensive Care, 2023, 2(5): e0035.
25. Ichinose A; Japanese Collaborative Research Group on AH. Autoimmune acquired factor XIII deficiency due to anti-factor XIII/13 antibodies: a summary of 93 patients. Blood Rev, 2017, 31(1): 37-45.
26. Souri M, Osaki T, Ichinose A. Detection of factor XIII inhibitors in 33 patients with autoimmune factor XIII deficiency in Japan. Int J Hematol, 2024, 120(4): 472-481.
27. Smith J, Bodine JS, Cunningham MT, et al. Perioperative therapeutic plasma exchange in a patient with rare Factor XIII inhibitor. Transfus Apher Sci, 2023, 62(3): 103654.
28. Song J, Liu L, Ding B, et al. Comparison of outcomes in autoimmune acquired factor XIII deficiency with and without underlying diseases: a systematic review. J Thromb Thrombolysis, 2025: 1-9.
29. Ichinose A, Kohler HP, Philippou H, et al. Recommendation for ISTH/SSC criterion 2015 for autoimmune acquired factor XIII/13 deficiency. Thromb Haemost, 2016, 116(4): 772-774.
30. 赵倩, 刘畅, 刘荣. 多学科协作模式下穿透性胎盘植入伴膀胱侵犯的围产期管理1例. 数理医药学杂志, 2025, 38(8): 629-635.

West China Medical Journal

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