RESEARCH PROGRESS OF ALCOHOL-INDUCED OSTEONECROSIS OF FEMORAL HEAD_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

GAN Di , ZHANG Changqing.

Department of Orthopedics, the Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R.China. Corresponding author: ZHANG Changqing, E-mail: zhangchangq@yahoo.com.cn;

Corresponding author：

Keywords：

Alcohol-induced osteonecrosis of femoral head; Epidemiology; Pathogenesis; Etiology

DOI：

10.7507/1002-1892.20130082

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Objective To review the research progress of alcohol-induced osteonecrosis of the femoral head (ONFH). Methods Recent literature concerning alcohol-induced ONFH was reviewed and summarized. Results Alcohol-induced ONFH accounte for approximately 1/3 of total ONFH. Alcohol intake and the incidence of ONFH has a significant dose-effect relationship. There are some correlations between alcohol-induced ONFH and lipid metabolism, secretion of corticosteroid, and some gene of alcohol or lipid metabolism. Conclusion The relationships between alcohol and lipid metabolism, and between alcohol and steroid are still the main direction of the research of ONFH. Gene level researches can not demonstrate the pathogenesis, therefore further research should be carried on.

Citation： GAN Di,ZHANG Changqing.. RESEARCH PROGRESS OF ALCOHOL-INDUCED OSTEONECROSIS OF FEMORAL HEAD. Chinese Journal of Reparative and Reconstructive Surgery, 2013, 27(3): 365-368. doi: 10.7507/1002-1892.20130082 Copy

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2.	Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect, 2003, 52: 337-355.
3.	李子荣. 科学诊断和治疗股骨头坏死. 中国修复重建外科杂志, 2005, 19(9): 685-686.
4.	王凤仪, 马在山, 马素英, 等. 山东中部地区人群股骨头坏死流行病学调查研究. 中国骨伤, 2001, 14(6): 345-346.
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6.	Kang JS, Park S, Song JH, et al. Prevalence of osteonecrosis of the femoral head: a nationwide epidemiologic analysis in Korea. J Arthroplasty, 2009, 24(8): 1178-1183.
7.	Yamaguchi R, Yamamoto T, Motomura G, et al. Incidence of nontraumatic osteonecrosis of the femoral head in the Japanese population. Arthritis Rheum, 2011, 63(10): 3169-3173.
8.	Fukushima W, Fujioka M, Kubo T, et al. Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 2010, 468(10): 2715-2724.
9.	Gold EW, Cangemi PJ. Incidence and pathogenesis of alcohol-induced osteonecrosis of the femoral head. Clin Orthop Relat Res, 1979, (143): 222-226.
10.	Matsuo K, Hirohata T, Sugioka Y, et al. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 1988, (234): 115-123.
11.	Hirota Y, Hirohata T, Fukuda K, et al. Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am J Epidemiol, 1993, 137(5): 530-538.
12.	Corrao G, Rubbiati L, Bagnardi V, et al. Alcohol and coronary heart disease: a meta-analysis. Addiction, 2000, 95(10): 1505-1523.
13.	Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study. Lancet, 2004, 363(9417): 1277-1281.
14.	石少辉, 李子荣, 孙伟, 等. 酒精性和激素性股骨头坏死的发病与脂质代谢. 中国组织工程研究与临床康复, 2011, 15(17): 3217-3220.
15.	Wang Y, Li Y, Mao K, et al. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res, 2003, (410): 213-224.
16.	Rico H, Gomez-Castresana F, Cabranes JA, et al. Increased blood cortisol in alcoholic patients with aseptic necrosis of the femoral head. Calcif Tissue Int, 1985, 37(6): 585-587.
17.	Badrick E, Bobak M, Britton A, et al. The relationship between alcohol consumption and cortisol secretion in an aging cohort. J Clin Endocrinol Metab, 2008, 93(3): 750-757.
18.	Cobb CF, Van Thiel DH. Mechanism of ethanol-induced adrenal stimulation. Alchol Clin Exp Res, 1982, 6(2): 202-206.
19.	赵凤朝, 李子荣, 张念非. 不同病因股骨头坏死的病理改变. 实用骨科杂志, 2005, 11(3): 210-213.
20.	Wall TL, Schoedel K, Ring HZ, et al. Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research. Nicotine Tob Res, 2007, 9 Suppl 3: S459-474.
21.	Thomasson HR, Edenberg HJ, Crabb DW, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet, 1991, 48 (4): 677-681.
22.	Sakata R. A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. Kurume Med J, 2003, 50 (3-4): 121-130.
23.	Chao YC, Wang SJ, Chu HC, et al. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol, 2003, 38(5): 431-436.
24.	Kim H, Cho C, Cho Y, et al. Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. BMC Musculoskelet Disord, 2011, 12: 160.
25.	尹思, 张长青. 股骨头坏死与基因遗传多态性. 国际骨科学杂志, 2010, 31(3): 178-180, 189.

1. World Health Organization. Global status report on alcohol and Health[EB/OL]. (2012-06-13)[2012-12-19] http: //www. who. int/entity/substance_abuse/publications/global_alcohol_report/msbgsrwpr. pdf.
2. Lieberman JR, Berry DJ, Mont MA, et al. Osteonecrosis of the hip: management in the 21st century. Instr Course Lect, 2003, 52: 337-355.
3. 李子荣. 科学诊断和治疗股骨头坏死. 中国修复重建外科杂志, 2005, 19(9): 685-686.
4. 王凤仪, 马在山, 马素英, 等. 山东中部地区人群股骨头坏死流行病学调查研究. 中国骨伤, 2001, 14(6): 345-346.
5. 陈海涛, 安玉光, 张栋, 等. 广西各地区酒精性股骨头坏死的流行病学调查报告. 中国中医药资讯, 2010, 2(35): 277.
6. Kang JS, Park S, Song JH, et al. Prevalence of osteonecrosis of the femoral head: a nationwide epidemiologic analysis in Korea. J Arthroplasty, 2009, 24(8): 1178-1183.
7. Yamaguchi R, Yamamoto T, Motomura G, et al. Incidence of nontraumatic osteonecrosis of the femoral head in the Japanese population. Arthritis Rheum, 2011, 63(10): 3169-3173.
8. Fukushima W, Fujioka M, Kubo T, et al. Nationwide epidemiologic survey of idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 2010, 468(10): 2715-2724.
9. Gold EW, Cangemi PJ. Incidence and pathogenesis of alcohol-induced osteonecrosis of the femoral head. Clin Orthop Relat Res, 1979, (143): 222-226.
10. Matsuo K, Hirohata T, Sugioka Y, et al. Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res, 1988, (234): 115-123.
11. Hirota Y, Hirohata T, Fukuda K, et al. Association of alcohol intake, cigarette smoking, and occupational status with the risk of idiopathic osteonecrosis of the femoral head. Am J Epidemiol, 1993, 137(5): 530-538.
12. Corrao G, Rubbiati L, Bagnardi V, et al. Alcohol and coronary heart disease: a meta-analysis. Addiction, 2000, 95(10): 1505-1523.
13. Choi HK, Atkinson K, Karlson EW, et al. Alcohol intake and risk of incident gout in men: a prospective study. Lancet, 2004, 363(9417): 1277-1281.
14. 石少辉, 李子荣, 孙伟, 等. 酒精性和激素性股骨头坏死的发病与脂质代谢. 中国组织工程研究与临床康复, 2011, 15(17): 3217-3220.
15. Wang Y, Li Y, Mao K, et al. Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res, 2003, (410): 213-224.
16. Rico H, Gomez-Castresana F, Cabranes JA, et al. Increased blood cortisol in alcoholic patients with aseptic necrosis of the femoral head. Calcif Tissue Int, 1985, 37(6): 585-587.
17. Badrick E, Bobak M, Britton A, et al. The relationship between alcohol consumption and cortisol secretion in an aging cohort. J Clin Endocrinol Metab, 2008, 93(3): 750-757.
18. Cobb CF, Van Thiel DH. Mechanism of ethanol-induced adrenal stimulation. Alchol Clin Exp Res, 1982, 6(2): 202-206.
19. 赵凤朝, 李子荣, 张念非. 不同病因股骨头坏死的病理改变. 实用骨科杂志, 2005, 11(3): 210-213.
20. Wall TL, Schoedel K, Ring HZ, et al. Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research. Nicotine Tob Res, 2007, 9 Suppl 3: S459-474.
21. Thomasson HR, Edenberg HJ, Crabb DW, et al. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet, 1991, 48 (4): 677-681.
22. Sakata R. A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. Kurume Med J, 2003, 50 (3-4): 121-130.
23. Chao YC, Wang SJ, Chu HC, et al. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. Alcohol Alcohol, 2003, 38(5): 431-436.
24. Kim H, Cho C, Cho Y, et al. Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. BMC Musculoskelet Disord, 2011, 12: 160.
25. 尹思, 张长青. 股骨头坏死与基因遗传多态性. 国际骨科学杂志, 2010, 31(3): 178-180, 189.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF ALCOHOL-INDUCED OSTEONECROSIS OF FEMORAL HEAD

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