RESEARCH PROGRESS OF BIOREACTOR BIOPHYSICAL FACTORS IN CARTILAGE TISSUE ENGINEERING_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

YE Gang , ZHANG Fangbiao , SHI Hongcan.

Department of General Thoracic Surgery, Medical College of Yangzhou University, Yangzhou Jiangsu, 225001, P.R.China. Corresponding author: SHI Hongcan, E-mail: shihongcan@hotmail.com;

Corresponding author：

Keywords：

Cartilage tissue engineering; Bioreactor; Oxygen concentration; Hydrostatic pressure; Compressive force; Shear load

DOI：

10.7507/1002-1892.20130178

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Objective To review the recent research progress of the bioreactor biophysical factors in cartilage tissue engineering. Methods The related literature concerning the biophysical factors of bioreactor in cartilage tissue engineering was reviewed, analyzed, and summarized. Results Oxygen concentration, hydrostatic pressure, compressive force, and shear load in the bioreactor system have no unified standard parameters. Hydrostatic pressure and shear load have been in controversy, which restricts the application of bioreactors. Conclusion The biophysical factors of broreactor in cartilage tissue engineering have to be studied deeply.

Citation： YE Gang,ZHANG Fangbiao,SHI Hongcan.. RESEARCH PROGRESS OF BIOREACTOR BIOPHYSICAL FACTORS IN CARTILAGE TISSUE ENGINEERING. Chinese Journal of Reparative and Reconstructive Surgery, 2013, 27(7): 810-813. doi: 10.7507/1002-1892.20130178 Copy

1.	Oragui E, Nannaparaju M, Khan WS. The role of bioreactors in tissue engineering for musculoskeletal applications. Open Orthop J, 2011, 5 Suppl 2: 267-270.
2.	Mabvuure N, Hindocha S, Khan WS. The role of bioreactors in cartilage tissue engineering. Curr Stem Cell Res Ther, 2012, 7(4): 287-292.
3.	Govoni M, Lotti F, Biagiotti L, et al. An innovative stand-alone bioreactor for the highly reproducible transfer of cyclic mechanical stretch to stem cells cultured in a 3D scaffold. J Tissue Eng Regen Med, 2012. [Epub ahead of print].
4.	Hoening E, Winkler T, Mielke G, et al. High amplitude direct compressive strain enhances mechanical properties of scaffold-free tissue engineered cartilage. Tissue Eng Part A, 2011, 17(9-10): 1401-1411.
5.	Cinbiz MN, Tiğli RS, Beşkardeş IG, et al. Computational fluid dynamies modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering. J Biotechnol, 2010, 150(3): 389-395.
6.	Malda J, Martens DE, Tramper J, et al. Cartilage tissue engineering: controversy in the effect of oxygen. Crit Rev Biotechnol, 2003, 23(3): 175-194.
7.	Wernike E, Li Z, Alini M, et al. Effect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs. Cell Tissue Res, 2008, 331(2): 473-483.
8.	Das RH, van Osch GJ, Kreukniet M, et al. Effects of individual control of pH and hypoxia in chondrocyte culture. J Orthop Res, 2010, 28(4): 537-545.
9.	Lovett M, Rockwood D, Baryshyan A, et al. Simple modular bioreactors for tissue engineering: a system for characterization of oxygen gradients, human mesenchymal stemcell differentiation and prevascularization. Tissue Eng Part C Methods, 2010, 16(6): 1565-1573.
10.	Meyer EG, Buckley CT, Thorpe SD, et al. Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression. J Biomech, 2010, 43(13): 2516-2523.
11.	Schrobback K, Klein TJ, Crawford R, et al. Effects of oxygen and culture system on in vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes. Cell Tissue Res, 2012, 347(3): 649-663.
12.	Terkhorn SP, Bohensky J, Shapiro IM, et al. Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity. J Cell Physiol, 2007, 210(1): 257-265.
13.	Pörtner R, Goepfert C, Wiegandt K, et al. Technical strategies to improve tissue engineering of cartilage-carrier-constructs. Adv Biochem Eng Biotechnol, 2009, 112: 145-181.
14.	Schulz RM, Bader A. Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J, 2007, 36(4-5): 539-568.
15.	Ogawa R, Mizuno S, Murphy GF, et al. The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells. Tissue Eng Part A, 2009, 15(10): 2937-2945.
16.	Elder BD, Athanasiou KA. Hydrostatic pressure in articular cartilage tissue engineering: from chondrocytes to tissue regeneration. Tissue Eng Part B Rev, 2009, 15(1): 43-53.
17.	Jeong JY, Park SH, Shin JW, et al. Effects of intermittent hydrostatic ressure magnitude on the chondrogenesis of MSCs without biochemical agents under 3D co-culture. J Mater Sci Mater Med, 2012, 23(11): 2773-2781.
18.	Takahashi I, Nuckolls GH, Takahashi K, et al. Compressive force promotes sox9, type II collagen and aggrecan and inhibits IL-1beta expression resulting in chondrogenensis in mouse embryonic limb bud mesenchymal cells. J Cell Sci, 1998, 111(Pt 14): 2067-2076.
19.	Nugent GE, Schmidt TA, Schumacher BL, et al. Static and dynamic compression regulate cartilage metabolism of PRoteoGlycan 4 (PRG4). Biorheology, 2006, 43(3-4): 191-200.
20.	Li KW, Williamson AK, Wang AS, et al. Growth responses of cartilage to static and dynamic compression. Clin Orthop Relat Res, 2001, (391 Suppl): S34-48.
21.	Park S, Hung CT, Ateshian GA. Mechanical response of bovine articular cartilage under dynamic unconfined compression loading at physiological stress levels. Osteoarthritis Cartilage, 2004, 12(1): 65-73.
22.	Haugh MG, Meyer EG, Thorpe SD, et al. Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression. Tissue Eng Part A, 2011, 17(23-24): 3085-3093.
23.	Schätti O, Grad S, Goldhahn J, et al. A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells. Eur Cell Mater, 2011, 22: 214-225.
24.	Liu C, Abedian R, Meister R, et al. Influence of perfusion and compression on the proliferation and differentiation of bone mesenchymal stromal cells seeded on polyurethane scaffolds. Biomaterials, 2012, 33(4): 1052-1064.
25.	Huang AH, Farrell MJ, Mauck RL. Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. J Biomech, 2010, 43(1): 128-136.
26.	Richardson SM, Hoyland JA, Mobasheri R, et al. Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articu-lar cartilage and intervertebral disc tissue engineering. J Cell Physiol, 2010, 222(1): 23-32.
27.	Hoenig E, Winkler T, Mielke G, et al. High amplitude direct compressive strain enhances mechanical properties of scaffold-free tissue-engineered cartilage. Tissue Eng Part A, 2011, 17(9-10): 1401-1411.
28.	孙明林, 朱雷, 吕丹, 等. 不同参数滚压模式对兔BMSCs向软骨细胞分化促进作用的研究. 中国修复重建外科杂志, 2013, 27(1): 89-94.
29.	Huang AH, Farrell MJ, Kim M, et al. Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. Eur Cell Mater, 2010, 19: 72-85.
30.	Thorpe SD, Buckley CT, Vinardell T, et al. Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. Biochem Biophys Res Commun, 2008, 377(2): 458-462.
31.	Zhu F, Wang P, Lee NH, et al. Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One, 2010, 5(12): e15174.
32.	Wang P, Zhu F, Tong Z, et al. Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J, 2011, 25(10): 3401-3415.
33.	Wang P, Zhu F, Lee NH, et al. Shear-induced interleukin-6 synthesis in chondrocyte: roles of E prostanoid (EP) 2 and EP3 in cAMP/proteinkinase A-and PI3-K/Akt-dependent NF-kappa B activation. J Biol Chem, 2010, 285(32): 24793-24804.
34.	谢甲琦, 魏旭峰, 康小军, 等. 剪应力诱导骨髓间充质干细胞向内皮细胞分化. 第四军医大学学报, 2009, 30(7): 588-590.
35.	Hambor JE. Bioreactor design and bioprocess controls for industrialized cell processing. BioProcess Int, 2012, 10(6): 22-33.

1. Oragui E, Nannaparaju M, Khan WS. The role of bioreactors in tissue engineering for musculoskeletal applications. Open Orthop J, 2011, 5 Suppl 2: 267-270.
2. Mabvuure N, Hindocha S, Khan WS. The role of bioreactors in cartilage tissue engineering. Curr Stem Cell Res Ther, 2012, 7(4): 287-292.
3. Govoni M, Lotti F, Biagiotti L, et al. An innovative stand-alone bioreactor for the highly reproducible transfer of cyclic mechanical stretch to stem cells cultured in a 3D scaffold. J Tissue Eng Regen Med, 2012. [Epub ahead of print].
4. Hoening E, Winkler T, Mielke G, et al. High amplitude direct compressive strain enhances mechanical properties of scaffold-free tissue engineered cartilage. Tissue Eng Part A, 2011, 17(9-10): 1401-1411.
5. Cinbiz MN, Tiğli RS, Beşkardeş IG, et al. Computational fluid dynamies modeling of momentum transport in rotating wall perfused bioreactor for cartilage tissue engineering. J Biotechnol, 2010, 150(3): 389-395.
6. Malda J, Martens DE, Tramper J, et al. Cartilage tissue engineering: controversy in the effect of oxygen. Crit Rev Biotechnol, 2003, 23(3): 175-194.
7. Wernike E, Li Z, Alini M, et al. Effect of reduced oxygen tension and long-term mechanical stimulation on chondrocyte-polymer constructs. Cell Tissue Res, 2008, 331(2): 473-483.
8. Das RH, van Osch GJ, Kreukniet M, et al. Effects of individual control of pH and hypoxia in chondrocyte culture. J Orthop Res, 2010, 28(4): 537-545.
9. Lovett M, Rockwood D, Baryshyan A, et al. Simple modular bioreactors for tissue engineering: a system for characterization of oxygen gradients, human mesenchymal stemcell differentiation and prevascularization. Tissue Eng Part C Methods, 2010, 16(6): 1565-1573.
10. Meyer EG, Buckley CT, Thorpe SD, et al. Low oxygen tension is a more potent promoter of chondrogenic differentiation than dynamic compression. J Biomech, 2010, 43(13): 2516-2523.
11. Schrobback K, Klein TJ, Crawford R, et al. Effects of oxygen and culture system on in vitro propagation and redifferentiation of osteoarthritic human articular chondrocytes. Cell Tissue Res, 2012, 347(3): 649-663.
12. Terkhorn SP, Bohensky J, Shapiro IM, et al. Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity. J Cell Physiol, 2007, 210(1): 257-265.
13. Pörtner R, Goepfert C, Wiegandt K, et al. Technical strategies to improve tissue engineering of cartilage-carrier-constructs. Adv Biochem Eng Biotechnol, 2009, 112: 145-181.
14. Schulz RM, Bader A. Cartilage tissue engineering and bioreactor systems for the cultivation and stimulation of chondrocytes. Eur Biophys J, 2007, 36(4-5): 539-568.
15. Ogawa R, Mizuno S, Murphy GF, et al. The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells. Tissue Eng Part A, 2009, 15(10): 2937-2945.
16. Elder BD, Athanasiou KA. Hydrostatic pressure in articular cartilage tissue engineering: from chondrocytes to tissue regeneration. Tissue Eng Part B Rev, 2009, 15(1): 43-53.
17. Jeong JY, Park SH, Shin JW, et al. Effects of intermittent hydrostatic ressure magnitude on the chondrogenesis of MSCs without biochemical agents under 3D co-culture. J Mater Sci Mater Med, 2012, 23(11): 2773-2781.
18. Takahashi I, Nuckolls GH, Takahashi K, et al. Compressive force promotes sox9, type II collagen and aggrecan and inhibits IL-1beta expression resulting in chondrogenensis in mouse embryonic limb bud mesenchymal cells. J Cell Sci, 1998, 111(Pt 14): 2067-2076.
19. Nugent GE, Schmidt TA, Schumacher BL, et al. Static and dynamic compression regulate cartilage metabolism of PRoteoGlycan 4 (PRG4). Biorheology, 2006, 43(3-4): 191-200.
20. Li KW, Williamson AK, Wang AS, et al. Growth responses of cartilage to static and dynamic compression. Clin Orthop Relat Res, 2001, (391 Suppl): S34-48.
21. Park S, Hung CT, Ateshian GA. Mechanical response of bovine articular cartilage under dynamic unconfined compression loading at physiological stress levels. Osteoarthritis Cartilage, 2004, 12(1): 65-73.
22. Haugh MG, Meyer EG, Thorpe SD, et al. Temporal and spatial changes in cartilage-matrix-specific gene expression in mesenchymal stem cells in response to dynamic compression. Tissue Eng Part A, 2011, 17(23-24): 3085-3093.
23. Schätti O, Grad S, Goldhahn J, et al. A combination of shear and dynamic compression leads to mechanically induced chondrogenesis of human mesenchymal stem cells. Eur Cell Mater, 2011, 22: 214-225.
24. Liu C, Abedian R, Meister R, et al. Influence of perfusion and compression on the proliferation and differentiation of bone mesenchymal stromal cells seeded on polyurethane scaffolds. Biomaterials, 2012, 33(4): 1052-1064.
25. Huang AH, Farrell MJ, Mauck RL. Mechanics and mechanobiology of mesenchymal stem cell-based engineered cartilage. J Biomech, 2010, 43(1): 128-136.
26. Richardson SM, Hoyland JA, Mobasheri R, et al. Mesenchymal stem cells in regenerative medicine: Opportunities and challenges for articu-lar cartilage and intervertebral disc tissue engineering. J Cell Physiol, 2010, 222(1): 23-32.
27. Hoenig E, Winkler T, Mielke G, et al. High amplitude direct compressive strain enhances mechanical properties of scaffold-free tissue-engineered cartilage. Tissue Eng Part A, 2011, 17(9-10): 1401-1411.
28. 孙明林, 朱雷, 吕丹, 等. 不同参数滚压模式对兔BMSCs向软骨细胞分化促进作用的研究. 中国修复重建外科杂志, 2013, 27(1): 89-94.
29. Huang AH, Farrell MJ, Kim M, et al. Long-term dynamic loading improves the mechanical properties of chondrogenic mesenchymal stem cell-laden hydrogel. Eur Cell Mater, 2010, 19: 72-85.
30. Thorpe SD, Buckley CT, Vinardell T, et al. Dynamic compression can inhibit chondrogenesis of mesenchymal stem cells. Biochem Biophys Res Commun, 2008, 377(2): 458-462.
31. Zhu F, Wang P, Lee NH, et al. Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One, 2010, 5(12): e15174.
32. Wang P, Zhu F, Tong Z, et al. Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J, 2011, 25(10): 3401-3415.
33. Wang P, Zhu F, Lee NH, et al. Shear-induced interleukin-6 synthesis in chondrocyte: roles of E prostanoid (EP) 2 and EP3 in cAMP/proteinkinase A-and PI3-K/Akt-dependent NF-kappa B activation. J Biol Chem, 2010, 285(32): 24793-24804.
34. 谢甲琦, 魏旭峰, 康小军, 等. 剪应力诱导骨髓间充质干细胞向内皮细胞分化. 第四军医大学学报, 2009, 30(7): 588-590.
35. Hambor JE. Bioreactor design and bioprocess controls for industrialized cell processing. BioProcess Int, 2012, 10(6): 22-33.

Chinese Journal of Reparative and Reconstructive Surgery

RESEARCH PROGRESS OF BIOREACTOR BIOPHYSICAL FACTORS IN CARTILAGE TISSUE ENGINEERING

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