APPLICATION OF THREE-DIMENSIONAL PRINTING CUSTOMIZED BONE CEMENT MODELS ON REPAIR OF BONE DEFECT OF LIMBS_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

Yamuhanmode·Alike ¹ , Ayiguli·Kasimu ² , Alimujiang·Abulaiti ¹ ,  Aihemaitijiang·Yusufu ¹ ,  Wurikaixi·Ayiti ²

1. Department of Reparative Microsurgery, Center of Orthopaedic Surgery, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China;
2. Mechanical Engineering Academy of Xinjiang University;

Corresponding author：

Aihemaitijiang·Yusufu, Email: ahmatjang@163.com; Wurikaixi·Ayiti, Email: wurikaixi@sina.com

Keywords：

Three-dimensional printing; Bone cement shaping module; Bone defect; Repair

DOI：

10.7507/1002-1892.20160300

Video：

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Objective To determine the feasibility of fabricating molds using a three-dimensional (3D) printer for producing customized bone cement for repairing bone defect. Methods Between February 2015 and March 2016, 13 patients with bone defects were treated. There were 9 males and 4 females with an average age of 38.4 years (range, 20-58 years), including 7 cases of chronic osteomyelitis, 3 cases of bone tuberculosis, 2 cases of bone tumor, and 1 case of ischemic necrosis. The defect located at the humerus in 3 cases, at the femur in 4 cases, and at the tibia in 6 cases. The defect ranged from 4.5 to 8.9 cm in length (mean, 6.7 cm). Before operation, Mimics10.01 software was used to design cement prosthesis, 3-matic software to design shaping module which was printed by 3D technology. After removal of the lesion bone during operation, bone cement was filled into the shaping module to prepare bone cement prosthesis for repairing defect. Results The measurement result from Image J software showed that the match index of interface between the mirror restored digital and bone interface was 95.1%-97.4% (mean, 96.3%); the match index of interface between bone cement prosthesis and bone interface was 91.2%-94.7% (mean, 93.2%). It was one time success during separation between formed bone cement and shaping module without any shatter or fall off. All incisions healed by first intention. The cases were followed up 5-17 months (mean, 9.4 months). X-ray films and CT scans showed good position of bone cement prosthesis without any fracture; no peripheral fracture occurred. Conclusion 3D printing customized bone cement shaping module can shorten the operation time, and customized bone cement prothesis has good match with bone interface, so it can avoid further adjustment and accord with the biomechanical rules of surgical site.

Citation： Yamuhanmode·Alike, Ayiguli·Kasimu, Alimujiang·Abulaiti, Aihemaitijiang·Yusufu, Wurikaixi·Ayiti. APPLICATION OF THREE-DIMENSIONAL PRINTING CUSTOMIZED BONE CEMENT MODELS ON REPAIR OF BONE DEFECT OF LIMBS. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(12): 1447-1451. doi: 10.7507/1002-1892.20160300 Copy

1.	Magnan B, Bondi M, Maluta T, et al. Acrylic bone cement:current concept review. Musculoskelet Surg, 2013, 97(2):93-100.
2.	Kung WM, Lin MS. A simplified technique for polymethyl methacrylate cranioplasty:combined cotton stacking and finger fracture method. Brain Inj, 2012, 26(13-14):1737-1742.
3.	Sorour M, Caton WL 3rd, Couldwell WT. Technique for methyl methacrylate cranioplasty to optimize cosmetic outcome. Acta Neurochir (Wien), 2014, 156(1):207-209.
4.	Bartus C, William Hanke C, Daro-Kaftan E. A decade of experience with injectable poly-L-lactic acid:a focus on safety. Dermatol Surg, 2013, 39(5):698-705.
5.	Arnedos M, Soria JC, Andre F, et al. Personalized treatments of cancer patients:a reality in daily practice, a costly dream or a shared vision of the future from the oncology community? Cancer Treat Rev, 2014, 40(10):1192-1198.
6.	叶堃, 王金武, 胡志刚, 等. 3D打印钛合金个性化骨盆假体生物力学的初步有限元分析.中华创伤骨科杂志, 2015, 17(1):18-22.
7.	秦勉, 刘亚雄, 贺健康, 等.数字化设计与3-D打印技术在个性化医疗中的应用.中国修复重建外科杂志, 2014, 28(3):286-291.
8.	O'Reilly EB, Barnett S, Madden C, et al. Computed-tomography modeled polyether ether ketone (PEEK) implants in revision cranioplasty. J Plast Reconstr Aesthet Surg, 2015, 68(3):329-338.
9.	Tan ET, Ling JM, Dinesh SK. The feasibility of producing patient-specific acrylic cranioplasty implants with a low-cost 3D printer. J Neurosurg, 2016, 124(5):1531-1537.
10.	Aboul-Hosn Centenero S, Hernández-Alfaro F. 3D planning in orthognathic surgery:CAD/CAM surgical splints and prediction of the soft and hard tissues results-our experience in 16 cases. J Craniomaxillofac Surg, 2012, 40(2):162-168.
11.	Smith EJ, Anstey JA, Venne G, et al. Using additive manufacturing in accuracy evaluation of reconstructions from computed tomography. Proc Inst Mech Eng H, 2013, 227(5):551-559.
12.	刘琨, 赵汝岗, 张强. 3D打印技术在骨科的应用研究进展.中华创伤骨科杂志, 2015, 17(1):63-66.
13.	Peniston SJ, Choi SJ. Effect of sterilization on the physicochemical properties of molded poly (L-lactic acid). J Biomed Mater Res B Appl Biomater, 2007, 80(1):67-77.
14.	Golz T, Graham CR, Busch LC, et al. Temperature elevation during simulated polymethylmethacrylate (PMMA) cranioplasty in a cadaver model. J Clin Neurosci, 2010, 17(5):617-622.
15.	Gronet PM, Waskewicz GA, Richardson C. Preformed acrylic cranial implants using fused deposition modeling:a clinical report. J Prosthet Dent, 2003, 90(5):429-433.
16.	Vleggaar D, Fitzgerald R, Lorenc ZP. Composition and mechanism of action of poly-L-lactic acid in soft tissue augmentation. J Drugs Dermatol, 2014, 13(4 Suppl):s29-s31.
17.	Tomšič A, Palmen M, Versteegh MI, et al. Prosthesis dislocation after transapical valve-in-valve mitral valve implantation. Can J Cardiol, 2016.[Epub ahead of print].

1. Magnan B, Bondi M, Maluta T, et al. Acrylic bone cement:current concept review. Musculoskelet Surg, 2013, 97(2):93-100.
2. Kung WM, Lin MS. A simplified technique for polymethyl methacrylate cranioplasty:combined cotton stacking and finger fracture method. Brain Inj, 2012, 26(13-14):1737-1742.
3. Sorour M, Caton WL 3rd, Couldwell WT. Technique for methyl methacrylate cranioplasty to optimize cosmetic outcome. Acta Neurochir (Wien), 2014, 156(1):207-209.
4. Bartus C, William Hanke C, Daro-Kaftan E. A decade of experience with injectable poly-L-lactic acid:a focus on safety. Dermatol Surg, 2013, 39(5):698-705.
5. Arnedos M, Soria JC, Andre F, et al. Personalized treatments of cancer patients:a reality in daily practice, a costly dream or a shared vision of the future from the oncology community? Cancer Treat Rev, 2014, 40(10):1192-1198.
6. 叶堃, 王金武, 胡志刚, 等. 3D打印钛合金个性化骨盆假体生物力学的初步有限元分析.中华创伤骨科杂志, 2015, 17(1):18-22.
7. 秦勉, 刘亚雄, 贺健康, 等.数字化设计与3-D打印技术在个性化医疗中的应用.中国修复重建外科杂志, 2014, 28(3):286-291.
8. O'Reilly EB, Barnett S, Madden C, et al. Computed-tomography modeled polyether ether ketone (PEEK) implants in revision cranioplasty. J Plast Reconstr Aesthet Surg, 2015, 68(3):329-338.
9. Tan ET, Ling JM, Dinesh SK. The feasibility of producing patient-specific acrylic cranioplasty implants with a low-cost 3D printer. J Neurosurg, 2016, 124(5):1531-1537.
10. Aboul-Hosn Centenero S, Hernández-Alfaro F. 3D planning in orthognathic surgery:CAD/CAM surgical splints and prediction of the soft and hard tissues results-our experience in 16 cases. J Craniomaxillofac Surg, 2012, 40(2):162-168.
11. Smith EJ, Anstey JA, Venne G, et al. Using additive manufacturing in accuracy evaluation of reconstructions from computed tomography. Proc Inst Mech Eng H, 2013, 227(5):551-559.
12. 刘琨, 赵汝岗, 张强. 3D打印技术在骨科的应用研究进展.中华创伤骨科杂志, 2015, 17(1):63-66.
13. Peniston SJ, Choi SJ. Effect of sterilization on the physicochemical properties of molded poly (L-lactic acid). J Biomed Mater Res B Appl Biomater, 2007, 80(1):67-77.
14. Golz T, Graham CR, Busch LC, et al. Temperature elevation during simulated polymethylmethacrylate (PMMA) cranioplasty in a cadaver model. J Clin Neurosci, 2010, 17(5):617-622.
15. Gronet PM, Waskewicz GA, Richardson C. Preformed acrylic cranial implants using fused deposition modeling:a clinical report. J Prosthet Dent, 2003, 90(5):429-433.
16. Vleggaar D, Fitzgerald R, Lorenc ZP. Composition and mechanism of action of poly-L-lactic acid in soft tissue augmentation. J Drugs Dermatol, 2014, 13(4 Suppl):s29-s31.
17. Tomšič A, Palmen M, Versteegh MI, et al. Prosthesis dislocation after transapical valve-in-valve mitral valve implantation. Can J Cardiol, 2016.[Epub ahead of print].

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APPLICATION OF THREE-DIMENSIONAL PRINTING CUSTOMIZED BONE CEMENT MODELS ON REPAIR OF BONE DEFECT OF LIMBS

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