PROGRESS OF TREATMENT AND PREVENTION OF BREAST CANCER RELATED LYMPHEDEMA_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

ZANGHuiran , BIYe ,  MULan

Department of Plastic and Aesthetic Surgery, Peking University People's Hospital, Beijing, 100044, P. R. China;

Corresponding author：

MULan, Email: mulan666@aliyun.com

Keywords：

Lymphedema; Breast cancer; Prevention; Complication; Lymphaticovenous anastomosis

DOI：

10.7507/1002-1892.20160322

Video：

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Objective To review the progress of treatment and prevention of breast cancer related lymphedema. Methods The recent literature concerning treatment and prevention of breast cancer related lymphedema was extensively consulted and reviewed. Results The treatment of lymphedema is now based on complete decongestive therapy, supplemented with medicine and surgery. Those procedures have been proved to be safe and effective. Sentinel lymph node biopsy, axillary reverse mapping, and lymphaticovenous anastomoses have been used to decrease the incidence of lymphedema. They show promising effectiveness in short term, but the long-term effectiveness needs further tests. Conclusion In clinical practice, many treatment methods are used to decrease lymphedema, and lymphedema prevention is playing an increasingly important role. Lymphaticovenous anastomoses shows a promising effectiveness in reducing lymphedema.

Citation： ZANGHuiran, BIYe, MULan. PROGRESS OF TREATMENT AND PREVENTION OF BREAST CANCER RELATED LYMPHEDEMA. Chinese Journal of Reparative and Reconstructive Surgery, 2016, 30(12): 1567-1570. doi: 10.7507/1002-1892.20160322 Copy

1.	Chen W, Zheng S, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2):115-132.
2.	Gärtner R, Jensen MB, Kronborg L, et al. Self-reported arm-lymphedema and functional impairment after breast cancer treatment-a nationwide study of prevalence and associated factors. Life Sciences, 2010, 19(6):506-515.
3.	Pusic AL, Cemal Y, Albornoz C, et al. Quality of life among breast cancer patients with lymphedema:a systematic review of patient-reported outcome instruments and outcomes. J Cancer Surviv, 2013, 7(1):83-92.
4.	Jensen MR, Simonsen L, Karlsmark T, et al. Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema. J Appl Physiol (1985), 2013, 114(1):19-27.
5.	Mihara M, Hara H, Hayashi Y, et al. Pathological steps of cancer-related lymphedema:histological changes in the collecting lymphatic vessels after lymphadenectomy. PLoS One, 2012, 7(7):e41126.
6.	Jammallo LS, Miller CL, Singer M, et al. Impact of body mass index and weight fluctuation on lymphedema risk in patients treated for breast cancer. Breast Cancer Res Treat, 2013, 142(1):59-67.
7.	McLaughlin SA, Wright MJ, Morris KT, et al. Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection:objective measurements. J Clin Oncol, 2008, 26(32):5213-5219.
8.	Jung SY, Shin KH, Kim M, et al. Treatment factors affecting breast cancer-related lymphedema after systemic chemotherapy and radiotherapy in stage Ⅱ/Ⅲ breast cancer patients. Breast Cancer Res Treat, 2014, 148(1):91-98.
9.	陈佳佳, 汪立, 于子优, 等.手法淋巴引流治疗乳腺癌术后上肢淋巴水肿.组织工程与重建外科杂志, 2015, 11(5):310-312.
10.	Melam GR, Buragadda S, Alhusaini AA, et al. Effect of complete decongestive therapy and home program on health-related quality of life in post mastectomy lymphedema patients. BMC Womens Health, 2016, 16:23.
11.	Angooti Oshnari L, Hosseini SA, Haghighat S, et al. The effect of complete decongestive therapy on edema volume reduction and pain in women with post breast surgery lymph edema. Iran J Cancer Prev, 2016, 9(2):e4209.
12.	孙韬, 沈洋.乳腺癌相关上肢淋巴水肿的中西医治疗进展.中国康复理论与实践, 2013, 19(5):461-464.
13.	O'Brien BM, Sykes P, Threlfall GN, et al. Microlymphaticovenous anastomoses for obstructive lymphedema. Plast Reconstr Surg, 1977, 60(2):197-211.
14.	Narushima M, Mihara M, Yamamoto Y, et al. The intravascular stenting method for treatment of extremity lymphedema with multiconfiguration lymphaticovenous anastomoses. Plast Reconstr Surg, 2010, 125(3):935-943.
15.	Campisi C, Bellini C, Campisi C, et al. Microsurgery for lymphedema:clinical research and long-term results. Microsurgery, 2010, 30(4):256-260.
16.	Yamamoto T, Yoshimatsu H, Yamamoto N, et al. Side-to-end Lymphaticovenular anastomosis through temporary lymphatic expansion. PLoS One, 2013, 8(3):e59523.
17.	穆兰花, 张寒, 陈茹, 等.乳房再造和胸壁修复同时应用血管化的淋巴移植修复治疗乳腺癌术后上肢淋巴水肿.临床肿瘤学杂志, 2013, 18(1):54-56.
18.	Cheng MH, Huang JJ, Wu C W, et al. The mechanism of vascularized lymph node transfer for lymphedema:natural lymphaticovenous drainage. Plast Reconstr Surg, 2014, 133(2):192e-198e.
19.	Becker C, Assouad J, Riquet M, et al. Postmastectomy lymphedema:long-term results following microsurgical lymph node transplantation. Annals of Surgery, 2006, 243(3):313-315.
20.	Thompson M, Korourian S, Henry-Tillman R, et al. Axillary reverse mapping (ARM):a new concept to identify and enhance lymphatic preservation. Ann Surg Oncol, 2007, 14(6):1890-1895.
21.	Han JW, Seo YJ, Choi JE, et al. The efficacy of arm node preserving surgery using axillary reverse mapping for preventing lymphedema in patients with breast cancer. J Breast Cancer, 2012, 15(1):91-97.
22.	Dayan JH, Dayan E, Smith ML. Reverse lymphatic mapping:a new technique for maximizing safety in vascularized lymph node transfer. Plast Reconstr Surg, 2015, 135(1):277-285.
23.	Boccardo F, Casabona F, De Cian F, et al. Lymphedema microsurgical preventive healing approach:a new technique for primary prevention of arm lymphedema after mastectomy. Ann Surg Oncol, 2009, 16(3):703-708.
24.	Boccardo F, Casabona F, De Cian F, et al. Lymphatic microsurgical preventing healing approach (LYMPHA) for primary surgical prevention of breast cancer-related lymphedema:over 4 years follow-up. Microsurgery, 2014, 34(6):421-424.
25.	Feldman S, Bansil H, Ascherman J, et al. Single Institution Experience with Lymphatic Microsurgical Preventive Healing Approach (LYMPHA) for the Primary Prevention of Lymphedema. Ann Surg Oncol, 2015, 22(10):3296-3301.
26.	Mu L, Peng Z, Zang H, et al. Operating microscope with near infrared imaging function for indocyanine green lymphography in prevention of lymphedema with lymphaticovenous anastomosis immediately after mastectomy and axillary dissection. Microsurgery, 2015.[Epub ahead of print].
27.	侍朋举, 赵刚, 蔡海峰, 等.一期静脉淋巴管吻合预防乳腺癌根治术后上肢淋巴水肿的临床研究.国际肿瘤学杂志, 2016, 43(1):1-4.

1. Chen W, Zheng S, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin, 2016, 66(2):115-132.
2. Gärtner R, Jensen MB, Kronborg L, et al. Self-reported arm-lymphedema and functional impairment after breast cancer treatment-a nationwide study of prevalence and associated factors. Life Sciences, 2010, 19(6):506-515.
3. Pusic AL, Cemal Y, Albornoz C, et al. Quality of life among breast cancer patients with lymphedema:a systematic review of patient-reported outcome instruments and outcomes. J Cancer Surviv, 2013, 7(1):83-92.
4. Jensen MR, Simonsen L, Karlsmark T, et al. Microvascular filtration is increased in the forearms of patients with breast cancer-related lymphedema. J Appl Physiol (1985), 2013, 114(1):19-27.
5. Mihara M, Hara H, Hayashi Y, et al. Pathological steps of cancer-related lymphedema:histological changes in the collecting lymphatic vessels after lymphadenectomy. PLoS One, 2012, 7(7):e41126.
6. Jammallo LS, Miller CL, Singer M, et al. Impact of body mass index and weight fluctuation on lymphedema risk in patients treated for breast cancer. Breast Cancer Res Treat, 2013, 142(1):59-67.
7. McLaughlin SA, Wright MJ, Morris KT, et al. Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection:objective measurements. J Clin Oncol, 2008, 26(32):5213-5219.
8. Jung SY, Shin KH, Kim M, et al. Treatment factors affecting breast cancer-related lymphedema after systemic chemotherapy and radiotherapy in stage Ⅱ/Ⅲ breast cancer patients. Breast Cancer Res Treat, 2014, 148(1):91-98.
9. 陈佳佳, 汪立, 于子优, 等.手法淋巴引流治疗乳腺癌术后上肢淋巴水肿.组织工程与重建外科杂志, 2015, 11(5):310-312.
10. Melam GR, Buragadda S, Alhusaini AA, et al. Effect of complete decongestive therapy and home program on health-related quality of life in post mastectomy lymphedema patients. BMC Womens Health, 2016, 16:23.
11. Angooti Oshnari L, Hosseini SA, Haghighat S, et al. The effect of complete decongestive therapy on edema volume reduction and pain in women with post breast surgery lymph edema. Iran J Cancer Prev, 2016, 9(2):e4209.
12. 孙韬, 沈洋.乳腺癌相关上肢淋巴水肿的中西医治疗进展.中国康复理论与实践, 2013, 19(5):461-464.
13. O'Brien BM, Sykes P, Threlfall GN, et al. Microlymphaticovenous anastomoses for obstructive lymphedema. Plast Reconstr Surg, 1977, 60(2):197-211.
14. Narushima M, Mihara M, Yamamoto Y, et al. The intravascular stenting method for treatment of extremity lymphedema with multiconfiguration lymphaticovenous anastomoses. Plast Reconstr Surg, 2010, 125(3):935-943.
15. Campisi C, Bellini C, Campisi C, et al. Microsurgery for lymphedema:clinical research and long-term results. Microsurgery, 2010, 30(4):256-260.
16. Yamamoto T, Yoshimatsu H, Yamamoto N, et al. Side-to-end Lymphaticovenular anastomosis through temporary lymphatic expansion. PLoS One, 2013, 8(3):e59523.
17. 穆兰花, 张寒, 陈茹, 等.乳房再造和胸壁修复同时应用血管化的淋巴移植修复治疗乳腺癌术后上肢淋巴水肿.临床肿瘤学杂志, 2013, 18(1):54-56.
18. Cheng MH, Huang JJ, Wu C W, et al. The mechanism of vascularized lymph node transfer for lymphedema:natural lymphaticovenous drainage. Plast Reconstr Surg, 2014, 133(2):192e-198e.
19. Becker C, Assouad J, Riquet M, et al. Postmastectomy lymphedema:long-term results following microsurgical lymph node transplantation. Annals of Surgery, 2006, 243(3):313-315.
20. Thompson M, Korourian S, Henry-Tillman R, et al. Axillary reverse mapping (ARM):a new concept to identify and enhance lymphatic preservation. Ann Surg Oncol, 2007, 14(6):1890-1895.
21. Han JW, Seo YJ, Choi JE, et al. The efficacy of arm node preserving surgery using axillary reverse mapping for preventing lymphedema in patients with breast cancer. J Breast Cancer, 2012, 15(1):91-97.
22. Dayan JH, Dayan E, Smith ML. Reverse lymphatic mapping:a new technique for maximizing safety in vascularized lymph node transfer. Plast Reconstr Surg, 2015, 135(1):277-285.
23. Boccardo F, Casabona F, De Cian F, et al. Lymphedema microsurgical preventive healing approach:a new technique for primary prevention of arm lymphedema after mastectomy. Ann Surg Oncol, 2009, 16(3):703-708.
24. Boccardo F, Casabona F, De Cian F, et al. Lymphatic microsurgical preventing healing approach (LYMPHA) for primary surgical prevention of breast cancer-related lymphedema:over 4 years follow-up. Microsurgery, 2014, 34(6):421-424.
25. Feldman S, Bansil H, Ascherman J, et al. Single Institution Experience with Lymphatic Microsurgical Preventive Healing Approach (LYMPHA) for the Primary Prevention of Lymphedema. Ann Surg Oncol, 2015, 22(10):3296-3301.
26. Mu L, Peng Z, Zang H, et al. Operating microscope with near infrared imaging function for indocyanine green lymphography in prevention of lymphedema with lymphaticovenous anastomosis immediately after mastectomy and axillary dissection. Microsurgery, 2015.[Epub ahead of print].
27. 侍朋举, 赵刚, 蔡海峰, 等.一期静脉淋巴管吻合预防乳腺癌根治术后上肢淋巴水肿的临床研究.国际肿瘤学杂志, 2016, 43(1):1-4.

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Chinese Journal of Reparative and Reconstructive Surgery

PROGRESS OF TREATMENT AND PREVENTION OF BREAST CANCER RELATED LYMPHEDEMA

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