Applications and prospects of graphene and its derivatives in bone repair_Chinese Journal of Reparative and Reconstructive Surgery

Authors：

DU Zhipo ¹ , MA Yizhan ² ^{共同第一作者} , WANG Cunyang ² ,  ZHANG Ruihong ³ ,  LI Xiaoming ²

1. Department of Orthopedics, the Fourth Central Hospital of Baoding City, Baoding Hebei, 072350, P. R. China;
2. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, 100083, P. R. China;
3. Department of Science and Education, the Fourth Central Hospital of Baoding City, Baoding Hebei, 072350, P. R. China;

Corresponding author：

ZHANG Ruihong, Email: 13931391449@163.com; LI Xiaoming, Email: x.m.li@hotmail.com

Keywords：

Graphene and its derivatives; graphene oxide; bone repair; signaling pathway

DOI：

10.7507/1002-1892.202410011

Video：

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Abstract Full text Figures/Tables Video References Cited by

Objective To summarize the latest research progress of graphene and its derivatives (GDs) in bone repair. Methods The relevant research literature at home and abroad in recent years was extensively accessed. The properties of GDs in bone repair materials, including mechanical properties, electrical conductivity, and antibacterial properties, were systematically summarized, and the unique advantages of GDs in material preparation, functionalization, and application, as well as the contributions and challenges to bone tissue engineering, were discussed. Results The application of GDs in bone repair materials has broad prospects, and the functionalization and modification technology effectively improve the osteogenic activity and material properties of GDs. GDs can induce osteogenic differentiation of stem cells through specific signaling pathways and promote osteogenic activity through immunomodulatory mechanisms. In addition, the parameters of GDs have significant effects on the cytotoxicity and degradation behavior.Conclusion GDs has great potential in the field of bone repair because of its excellent physical and chemical properties and biological properties. However, the cytotoxicity, biodegradability, and functionalization strategies of GDs still need to be further studied in order to achieve a wider application in the field of bone tissue engineering.

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9. Barba-Rosado LV, Carrascal-Hernández DC, Insuasty D, et al. Graphene oxide (GO) for the treatment of bone cancer: A systematic review and bibliometric analysis. Nanomaterials (Basel), 2024, 14(2): 186. doi: 10.3390/nano14020186.
10. Zhou H, Chen J, Zhang X, et al. Exploring the application of graphene oxide-based nanomaterials in the repair of osteoporotic fractures. Nanomaterials (Basel), 2024, 14(6): 553. doi: 10.3390/nano14060553.
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12. Li Y, Zhang K, Yin Y, et al. Amino-functionalized graphene oxide affects bacteria-phage interactions in aquatic environments. Water Res, 2024, 259: 121840. doi: 10.1016/j.watres.2024.121840.
13. Jaramillo-Fierro X, Cuenca G. Theoretical and experimental analysis of hydroxyl and epoxy group effects on graphene oxide properties. Nanomaterials (Basel), 2024, 14(8): 714. doi: 10.3390/nano14080714.
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